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Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder
Fan, Jie1,2; Gan, Jun1; Liu, Wanting1; Zhong, Mingtian3; Liao, Haiyan4; Zhang, Hongchun4; Yi, Jinyao1; Chan, Raymond C. K.5,6; Tan, Changlian4; Zhu, Xiongzhao1,2
First AuthorFan, Jie
2018-12-19
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
Correspondent Emailxiongzhaozhu@csu.edu.cn
ISSN1662-5153
SubtypeArticle
Volume12Pages:11
Contribution Rank5
Abstract

Background: Previous studies have indicated the resting-state default mode network (DMN) related connectivity serving as predictor of sustained attention performance in healthy people. Interestingly, sustained attention deficits as well as DMN-involved functional connectivity (FC) alterations are common in both patients with schizophrenia (SCZ) and with obsessive-compulsive disorder (OCD). Thus, the present study was designed to investigate whether the DMN related resting-state connectivity alterations in these two psychiatric disorders were neural correlates of their sustained attention impairments. Methods: The study included 17 SCZ patients, 35 OCD patients and 36 healthy controls (HCs). Sustained attention to response task was adopted to assess the sustained attention. Resting-state scan was administrated and seed-based whole-brain FC analyses were performed with seeds located in classical DMN regions including bilateral medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). Results: Both SCZ and OCD patients had poorer sustained attention than HCs. Sustained attention deficits in OCD was negatively correlated with their impaired FC of right mPFC-left superior frontal gyrus (SFG) within DMN, and that in SCZ was significantly correlated with their altered FC of left mPFC-bilateral anterior cingulate cortex (ACC) which indicated interaction between DMN and salience network. In addition, the FC between left mPFC and right parietal lobe indicating the interaction between DMN and frontal-parietal network was correlated with sustained attention in both SCZ and OCD. Conclusion: These findings suggest the importance of DMN-involved connectivity, both within and between networks in underlying sustained attention deficits in OCD and SCZ. Results further support the potential of resting-state FC in complementing information for cognitive deficits in psychiatric disorders.

KeywordSustained Attention Sustained Attention To Response Task Resting-state Functional Connectivity Default Mode Network Salience Network Frontal-parietal Network
DOI10.3389/fnbeh.2018.00319
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81371487] ; National Natural Science Foundation of China[81671341] ; National Key Technology Research and Development Program of the Ministry of Science and Technology of China[2012BA136B01]
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000453866300002
PublisherFRONTIERS MEDIA SA
WOS KeywordWorking-memory ; Brain Networks ; Scale ; Normalize ; History ; Cortex ; Adults
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27947
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhu, Xiongzhao
Affiliation1.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha, Hunan, Peoples R China
2.Cent S Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China
3.South China Normal Univ, Sch Psychol, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China
4.Cent S Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Hunan, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Fan, Jie,Gan, Jun,Liu, Wanting,et al. Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2018,12:11.
APA Fan, Jie.,Gan, Jun.,Liu, Wanting.,Zhong, Mingtian.,Liao, Haiyan.,...&Zhu, Xiongzhao.(2018).Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,12,11.
MLA Fan, Jie,et al."Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 12(2018):11.
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