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Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder | |
Fan, Jie1,2; Gan, Jun1; Liu, Wanting1; Zhong, Mingtian3; Liao, Haiyan4; Zhang, Hongchun4; Yi, Jinyao1; Chan, Raymond C. K.5,6; Tan, Changlian4; Zhu, Xiongzhao1,2 | |
第一作者 | Fan, Jie |
通讯作者邮箱 | xiongzhaozhu@csu.edu.cn |
心理所单位排序 | 5 |
摘要 | Background: Previous studies have indicated the resting-state default mode network (DMN) related connectivity serving as predictor of sustained attention performance in healthy people. Interestingly, sustained attention deficits as well as DMN-involved functional connectivity (FC) alterations are common in both patients with schizophrenia (SCZ) and with obsessive-compulsive disorder (OCD). Thus, the present study was designed to investigate whether the DMN related resting-state connectivity alterations in these two psychiatric disorders were neural correlates of their sustained attention impairments. Methods: The study included 17 SCZ patients, 35 OCD patients and 36 healthy controls (HCs). Sustained attention to response task was adopted to assess the sustained attention. Resting-state scan was administrated and seed-based whole-brain FC analyses were performed with seeds located in classical DMN regions including bilateral medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). Results: Both SCZ and OCD patients had poorer sustained attention than HCs. Sustained attention deficits in OCD was negatively correlated with their impaired FC of right mPFC-left superior frontal gyrus (SFG) within DMN, and that in SCZ was significantly correlated with their altered FC of left mPFC-bilateral anterior cingulate cortex (ACC) which indicated interaction between DMN and salience network. In addition, the FC between left mPFC and right parietal lobe indicating the interaction between DMN and frontal-parietal network was correlated with sustained attention in both SCZ and OCD. Conclusion: These findings suggest the importance of DMN-involved connectivity, both within and between networks in underlying sustained attention deficits in OCD and SCZ. Results further support the potential of resting-state FC in complementing information for cognitive deficits in psychiatric disorders. |
关键词 | Sustained Attention Sustained Attention To Response Task Resting-state Functional Connectivity Default Mode Network Salience Network Frontal-parietal Network |
2018-12-19 | |
语种 | 英语 |
DOI | 10.3389/fnbeh.2018.00319 |
发表期刊 | FRONTIERS IN BEHAVIORAL NEUROSCIENCE |
ISSN | 1662-5153 |
卷号 | 12页码:11 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | National Key Technology Research and Development Program of the Ministry of Science and Technology of China[2012BA136B01] ; National Natural Science Foundation of China[81671341] ; National Natural Science Foundation of China[81371487] ; National Natural Science Foundation of China[81371487] ; National Natural Science Foundation of China[81671341] ; National Key Technology Research and Development Program of the Ministry of Science and Technology of China[2012BA136B01] |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | Working-memory ; Brain Networks ; Scale ; Normalize ; History ; Cortex ; Adults |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
WOS类目 | Behavioral Sciences ; Neurosciences |
WOS记录号 | WOS:000453866300002 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/27947 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhu, Xiongzhao |
作者单位 | 1.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha, Hunan, Peoples R China 2.Cent S Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China 3.South China Normal Univ, Sch Psychol, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China 4.Cent S Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Hunan, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Fan, Jie,Gan, Jun,Liu, Wanting,et al. Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2018,12:11. |
APA | Fan, Jie.,Gan, Jun.,Liu, Wanting.,Zhong, Mingtian.,Liao, Haiyan.,...&Zhu, Xiongzhao.(2018).Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,12,11. |
MLA | Fan, Jie,et al."Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 12(2018):11. |
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