Institutional Repository of Key Laboratory of Mental Health, CAS
Functional brain abnormalities in major depressive disorder using the Hilbert-Huang transform | |
Yu, Haibin1; Li, Feng2; Wu, Tong1; Li, Rui3; Yao, Li1,4,5; Wang, Chuanyue2; Wu, Xia1,4,5 | |
第一作者 | Yu, Haibin |
通讯作者邮箱 | wuxia@bnu.edu.cn |
心理所单位排序 | 3 |
摘要 | Major depressive disorder is a common disease worldwide, which is characterized by significant and persistent depression. Non-invasive accessory diagnosis of depression can be performed by resting-state functional magnetic resonance imaging (rs-fMRI). However, the fMRI signal may not satisfy linearity and stationarity. The Hilbert-Huang transform (HHT) is an adaptive time-frequency localization analysis method suitable for nonlinear and non-stationary signals. The objective of this study was to apply the HHT to rs-fMRI to find the abnormal brain areas of patients with depression. A total of 35 patients with depression and 37 healthy controls were subjected to rs-fMRI. The HHT was performed to extract the Hilbert-weighted mean frequency of the rs-fMRI signals, and multivariate receiver operating characteristic analysis was applied to find the abnormal brain regions with high sensitivity and specificity. We observed differences in Hilbert-weighted mean frequency between the patients and healthy controls mainly in the right hippocampus, right parahippocampal gyrus, left amygdala, and left and right caudate nucleus. Subsequently, the above-mentioned regions were included in the results obtained from the compared region homogeneity and the fractional amplitude of low frequency fluctuation method. We found brain regions with differences in the Hilbert-weighted mean frequency, and examined their sensitivity and specificity, which suggested a potential neuroimaging biomarker to distinguish between patients with depression and healthy controls. We further clarified the pathophysiological abnormality of these regions for the population with major depressive disorder. |
关键词 | Depression Resting-state Functional Magnetic Resonance Imaging Hilbert-huang Transform Hilbert-weighted Mean Frequency Multivariate Receiver Operating Characteristic Analysis |
2018-12-01 | |
语种 | 英语 |
DOI | 10.1007/s11682-017-9816-6 |
发表期刊 | BRAIN IMAGING AND BEHAVIOR |
ISSN | 1931-7557 |
卷号 | 12期号:6页码:1556-1568 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2015G06] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support[ZYLX201403] ; Beijing Science and Technology Commission[D121100005012002] ; Funds for the general Program of the National Natural Science Foundation of China[81471389] ; Funds for the general Program of the National Natural Science Foundation of China[61571047] |
出版者 | SPRINGER |
WOS关键词 | Low-frequency Fluctuation ; Mood-regulating Circuit ; Resting-state Fmri ; Regional Homogeneity ; Treatment-resistant ; Neural Activity ; Connectivity ; Amplitude ; Unipolar ; Naive |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neuroimaging |
WOS记录号 | WOS:000454107000003 |
Q分类 | Q2 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/28020 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wu, Xia |
作者单位 | 1.Beijing Normal Univ, Coll Informat Sci & Technol, 19 Xin Jie Kou Wai Jie, Beijing 100875, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Beijing Inst Brain Disorders, Beijing Key Lab Mental Disorders,Ctr Schizophreni, Beijing 10088, Peoples R China 3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 5.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Haibin,Li, Feng,Wu, Tong,et al. Functional brain abnormalities in major depressive disorder using the Hilbert-Huang transform[J]. BRAIN IMAGING AND BEHAVIOR,2018,12(6):1556-1568. |
APA | Yu, Haibin.,Li, Feng.,Wu, Tong.,Li, Rui.,Yao, Li.,...&Wu, Xia.(2018).Functional brain abnormalities in major depressive disorder using the Hilbert-Huang transform.BRAIN IMAGING AND BEHAVIOR,12(6),1556-1568. |
MLA | Yu, Haibin,et al."Functional brain abnormalities in major depressive disorder using the Hilbert-Huang transform".BRAIN IMAGING AND BEHAVIOR 12.6(2018):1556-1568. |
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