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Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice
Wang, Yanli1; Lv, Ke2; Chen, Hailong2; Zhao, Mei3; Ji, Guohua2; Zhang, Yongliang1; Cao, Hongqing2; Kan, Guanghan2; Li, Yinghui1,2; Qu, Lina2
First AuthorYanli Wang
2018-12-21
Source PublicationBIOSCIENCE REPORTS
Correspondent Emaillina qu (linaqu@263.net) ; yinghui li (yinghuidd@vip.sina.com)
ISSN0144-8463
Subtypearticle
Volume38Pages:11
Contribution Rank3
Abstract

Circadian locomotor output cycles kaput protein (CLOCK) is a core transcription factor of complex integrated feedback loops in mammalian circadian clock. More genes have been reported to be regulated by CLOCK, however little is known about the role of CLOCK-mediated miRNAs. To dissect this, we used microarray analysis to measure miRNAs expression in suprachiasmatic nuclei (SCN) of wild-type (WT) and Clock(Delta 19) mutant mice at two different time points. We found that miRNAs regulation in two time points was extensive (nearly 75% of the miRNAs expressed at each time point), and very little overlap, with only six miRNAs in common. Besides this, the predicted CLOCK regulated miRNAs at two time points participated in extremely diverse pathways. We validated nine miRNAs (miR-125a-3p, miR-144, miR-199a-5p, miR-199b*, miR-200a, miR-200b, miR-203, miR-449a, and miR-96), which were involved in the same signaling pathway-hippo signaling pathway. The rhythms of these miRNAs showed a broad distribution of phase, amplitude, and waveform in Clock mutation. And further analysis indicated that there may be three models of miRNA-mediated circadian rhythms and hippo signaling pathway. MiRNA, the small player, may play a hub role in connecting circadian rhythms and other pathways via its multiple target genes networks.

DOI10.1042/BSR20180233
Indexed BySCI
Language英语
Funding ProjectState Key Laboratory of Space Medicine Fundamentals and Application in China[SFMA09A06] ; State Key Laboratory of Space Medicine Fundamentals and Application in China[SFMA13B02] ; Foundation of Advanced Space Medico-Engineering Research Project of China[2015SY54A0501] ; National Major Scientific Instrument and Equipment Development Project[2012YQ0401400901] ; National Major Scientific Instrument and Equipment Development Project[2013YQ19046706]
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000454266100010
PublisherPORTLAND PRESS LTD
WOS KeywordCIRCADIAN-CLOCK ; CELL AUTONOMY ; PROTEIN ; TIME
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28026
Collection健康与遗传心理学研究室
Corresponding AuthorLi, Yinghui; Qu, Lina
Affiliation1.Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China
2.China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing 100094, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yanli,Lv, Ke,Chen, Hailong,et al. Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice[J]. BIOSCIENCE REPORTS,2018,38:11.
APA Wang, Yanli.,Lv, Ke.,Chen, Hailong.,Zhao, Mei.,Ji, Guohua.,...&Qu, Lina.(2018).Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice.BIOSCIENCE REPORTS,38,11.
MLA Wang, Yanli,et al."Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice".BIOSCIENCE REPORTS 38(2018):11.
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