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Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice
Wang, Yanli1; Lv, Ke2; Chen, Hailong2; Zhao, Mei3; Ji, Guohua2; Zhang, Yongliang1; Cao, Hongqing2; Kan, Guanghan2; Li, Yinghui1,2; Qu, Lina2
通讯作者Li, Yinghui(yinghuidd@vip.sina.com) ; Qu, Lina(linaqu@263.net)
2018-12-21
发表期刊BIOSCIENCE REPORTS
ISSN0144-8463
卷号38页码:11
摘要Circadian locomotor output cycles kaput protein (CLOCK) is a core transcription factor of complex integrated feedback loops in mammalian circadian clock. More genes have been reported to be regulated by CLOCK, however little is known about the role of CLOCK-mediated miRNAs. To dissect this, we used microarray analysis to measure miRNAs expression in suprachiasmatic nuclei (SCN) of wild-type (WT) and Clock(Delta 19) mutant mice at two different time points. We found that miRNAs regulation in two time points was extensive (nearly 75% of the miRNAs expressed at each time point), and very little overlap, with only six miRNAs in common. Besides this, the predicted CLOCK regulated miRNAs at two time points participated in extremely diverse pathways. We validated nine miRNAs (miR-125a-3p, miR-144, miR-199a-5p, miR-199b*, miR-200a, miR-200b, miR-203, miR-449a, and miR-96), which were involved in the same signaling pathway-hippo signaling pathway. The rhythms of these miRNAs showed a broad distribution of phase, amplitude, and waveform in Clock mutation. And further analysis indicated that there may be three models of miRNA-mediated circadian rhythms and hippo signaling pathway. MiRNA, the small player, may play a hub role in connecting circadian rhythms and other pathways via its multiple target genes networks.
DOI10.1042/BSR20180233
收录类别SCI
语种英语
项目资助者National Major Scientific Instrument and Equipment Development Project ; Foundation of Advanced Space Medico-Engineering Research Project of China ; State Key Laboratory of Space Medicine Fundamentals and Application in China
资助项目National Major Scientific Instrument and Equipment Development Project[2013YQ19046706] ; National Major Scientific Instrument and Equipment Development Project[2012YQ0401400901] ; Foundation of Advanced Space Medico-Engineering Research Project of China[2015SY54A0501] ; State Key Laboratory of Space Medicine Fundamentals and Application in China[SFMA13B02] ; State Key Laboratory of Space Medicine Fundamentals and Application in China[SFMA09A06]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Cell Biology
WOS记录号WOS:000454266100010
出版者PORTLAND PRESS LTD
关键词[WOS]CIRCADIAN-CLOCK ; CELL AUTONOMY ; PROTEIN ; TIME
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/28026
专题健康与遗传心理学研究室
通讯作者Li, Yinghui; Qu, Lina
作者单位1.Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China
2.China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing 100094, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
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Wang, Yanli,Lv, Ke,Chen, Hailong,et al. Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice[J]. BIOSCIENCE REPORTS,2018,38:11.
APA Wang, Yanli.,Lv, Ke.,Chen, Hailong.,Zhao, Mei.,Ji, Guohua.,...&Qu, Lina.(2018).Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice.BIOSCIENCE REPORTS,38,11.
MLA Wang, Yanli,et al."Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock(Delta 19) mutant mice".BIOSCIENCE REPORTS 38(2018):11.
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