PSYCH OpenIR  > 中国科学院心理健康重点实验室
Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia
Lang, Xiao-E1; Zhu, Daomin2; Zhang, Guangya3; Du, Xiangdong3; Jia, Qiufang3; Yin, Guangzhong3; Chen, Dachun4; Xiu, Meihong4; Cao, Bo5; Wang, Li6; Li, Xiaosi2; Soares, Jair C.5; Zhang, Xiang Yang5,6
First AuthorLang, Xiao-E
Correspondent ;
Contribution Rank6

Accumulating evidence shows that disruption of white matter (WM) may be involved in the pathophysiology of schizophrenia, even at the onset of psychosis. However, very few studies have explored sex difference in its association with psychopathology in schizophrenia. This study aims to compare sex differences in clinical features and WM abnormalities in first-episode and drug-naive (FEDN) schizophrenia among Han Chinese inpatients. The WM fractional anisotropy (FA) values of the whole-brain were determined using voxel-based diffusion tensor imaging (DTI) in 39 (16 males and 23 females) FEDN patients with schizophrenia and 30 healthy controls (13 males and 17 females) matched for gender, age, and education. Patient psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). Our results showed that compared with the controls, the patients showed widespread areas of lower FA, including corpus callosum, brainstem, internal capsule, cingulate, and cerebellum (all adjusted p < 0.01). Further, male patients showed lower FA values in left cingulate (F = 4.92, p = 0.033), but higher scores on the PANSS total, positive, and general psychopathology subscale scores (all p < 0.01) than female patients. Multivariate regression analysis showed that for male patients, FA values in right corpus callosum were positively associated with the PANSS total (beta = 0.785, t = 3.76, p = 0.002) and the negative symptom scores (beta = 0.494, t = 2.20, p = 0.044), while for female patients, FA values in left cingulate were negatively associated with the PANSS positive symptom score (beta = -0.717, t = -2.25, p = 0.041). Our findings indicate sex difference in white matter disconnectivity and its association with psychopathological symptoms in an early course of schizophrenia onset.

Indexed BySCI
WOS KeywordMedicated Chronic-schizophrenia ; 1st Episode Schizophrenia ; Early-onset Schizophrenia ; Diffusion-tensor ; Gender-differences ; Abnormalities ; Integrity ; Psychosis ; Brain ; Microstructure
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000454241400001
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLang, Xiao-E; Zhang, Xiang Yang
Affiliation1.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China
2.Hefei Fourth Peoples Hosp, Anhui Mental Hlth Ctr, Hefei, Anhui, Peoples R China
3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Jiangsu, Peoples R China
4.Peking Univ, Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China
5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Lang, Xiao-E,Zhu, Daomin,Zhang, Guangya,et al. Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2018,8:8.
APA Lang, Xiao-E.,Zhu, Daomin.,Zhang, Guangya.,Du, Xiangdong.,Jia, Qiufang.,...&Zhang, Xiang Yang.(2018).Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia.TRANSLATIONAL PSYCHIATRY,8,8.
MLA Lang, Xiao-E,et al."Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia".TRANSLATIONAL PSYCHIATRY 8(2018):8.
Files in This Item:
File Name/Size DocType Version Access License
Sex difference in as(379KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lang, Xiao-E]'s Articles
[Zhu, Daomin]'s Articles
[Zhang, Guangya]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lang, Xiao-E]'s Articles
[Zhu, Daomin]'s Articles
[Zhang, Guangya]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lang, Xiao-E]'s Articles
[Zhu, Daomin]'s Articles
[Zhang, Guangya]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.