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Temporal Dynamics and Response Modulation across the Human Visual System in a Spatial Attention Task An ECoG Study
Martin, Anne B.1,9; Yang, Xiaofang2; Saalmann, Yuri B.1,10; Wang, Liang1,11; Shestyuk, Avgusta3; Lin, Jack J.5,6,7; Parvizi, Josef8; Knight, Robert T.3,4; Kastner, Sabine1,2
第一作者Martin, Anne B.
通讯作者邮箱ppliang@cnu.edu.cn ; fuxl@psych.ac.cn
摘要

The selection of behaviorally relevant information from cluttered visual scenes (often referred to as "attention") is mediated by a cortical large-scale network consisting of areas in occipital, temporal, parietal, and frontal cortex that is organized into a functional hierarchy of feedforward and feedback pathways. In the human brain, little is known about the temporal dynamics of attentional processing from studies at the mesoscopic level of electrocorticography (ECoG), that combines millisecond temporal resolution with precise anatomical localization of recording sites. We analyzed high-frequency broadband responses (HFB) responses from 626 electrodes implanted in 8 epilepsy patients who performed a spatial attention task. Electrode locations were reconstructed using a probabilistic atlas of the human visual system. HFB responses showed high spatial selectivity and tuning, constituting ECoG response fields (RFs), within and outside the topographic visual system. In accordance with monkey physiology studies, both RF widths and onset latencies increased systematically across the visual processing hierarchy. We used the spatial specificity of HFB responses to quantitatively study spatial attention effects and their temporal dynamics to probe a hierarchical top-down model suggesting that feedback signals back propagate the visual processing hierarchy. Consistent with such a model, the strengths of attentional modulation were found to be greater and modulation latencies to be shorter in posterior parietal cortex, middle temporal cortex and ventral extrastriate cortex compared with early visual cortex. However, inconsistent with such a model, attention effects were weaker and more delayed in anterior parietal and frontal cortex.

关键词Attention Latencies Onset Latencies Spatial Response Fields Topographic Atlas
2019-01-09
语种英语
DOI10.1523/JNEUROSCI.1889-18.2018
发表期刊JOURNAL OF NEUROSCIENCE
ISSN0270-6474
卷号39期号:2页码:333-352
期刊论文类型Article
收录类别SCI
资助项目James S. McDonnell Foundation 21st Century Science Initiative, Understanding Human Cognition, collaborative Grant ; National Institute of Neurological Disorders and Stroke[R01R37NS21135] ; National Institute of Mental Health[R01MH110311] ; National Institute of Mental Health[R01MH109954] ; National Institute of Mental Health[R01MH064043] ; National Institute of Mental Health Conte Center Grant[1P50MH109429] ; National Institute of Mental Health Conte Center Grant[1P50MH109429] ; National Institute of Mental Health[R01MH064043] ; National Institute of Mental Health[R01MH109954] ; National Institute of Mental Health[R01MH110311] ; National Institute of Neurological Disorders and Stroke[R01R37NS21135] ; James S. McDonnell Foundation 21st Century Science Initiative, Understanding Human Cognition, collaborative Grant
出版者SOC NEUROSCIENCE
WOS关键词Posterior Parietal Cortex ; Local-field Potentials ; Surface-based Analysis ; Cortical Areas V1 ; Neuronal Responses ; High-frequency ; Gamma-oscillations ; Electrical-stimulation ; Neural Mechanisms ; Macaque V1
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000455189900013
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/28105
专题中国科学院心理健康重点实验室
通讯作者Kastner, Sabine
作者单位1.Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA
2.Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA
3.Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
4.Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA
5.Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Orange, CA 92868 USA
6.Univ Calif Irvine, Dept Biomed Engn, Orange, CA 92868 USA
7.Univ Calif Irvine, Dept Neurol, Orange, CA 92868 USA
8.Stanford Univ, Dept Neurol & Neurol Sci, Palo Alto, CA 94304 USA
9.CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA
10.Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA
11.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Martin, Anne B.,Yang, Xiaofang,Saalmann, Yuri B.,et al. Temporal Dynamics and Response Modulation across the Human Visual System in a Spatial Attention Task An ECoG Study[J]. JOURNAL OF NEUROSCIENCE,2019,39(2):333-352.
APA Martin, Anne B..,Yang, Xiaofang.,Saalmann, Yuri B..,Wang, Liang.,Shestyuk, Avgusta.,...&Kastner, Sabine.(2019).Temporal Dynamics and Response Modulation across the Human Visual System in a Spatial Attention Task An ECoG Study.JOURNAL OF NEUROSCIENCE,39(2),333-352.
MLA Martin, Anne B.,et al."Temporal Dynamics and Response Modulation across the Human Visual System in a Spatial Attention Task An ECoG Study".JOURNAL OF NEUROSCIENCE 39.2(2019):333-352.
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