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Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine
Gao, Jun1,2,3,4; Li, Ming1,4,5
First AuthorGao, Jun
2019
Source PublicationJOURNAL OF PSYCHOPHARMACOLOGY
Correspondent Emailgaojunscience@126.com
ISSN0269-8811
SubtypeArticle
Volume33Issue:1Pages:86-100
Contribution Rank3
Abstract

Background: Antipsychotic treatment is effective in the treatment of psychosis, although it also brings with it some unwanted side effects and is associated with low compliance. Finding a non-pharmacological alternative for antipsychotic treatment is highly desirable. Aims: This preclinical study examined the 'antipsychotic' efficacy of such a behavioral technique using a conditioned avoidance response model. This technique, termed reinforcement attenuation (RA), is to administer a brief footshock (0.1-2.0 s, 0.8 mA) at the end of each trial regardless of whether a well-trained rat makes an avoidance response or not. Results: RA achieved the same avoidance suppressing effect as olanzapine (an atypical antipsychotic drug), including both acute suppression and sensitized suppression of avoidance response in well-trained Sprague-Dawley adult male rats. Interestingly, the RA-induced sensitization (an enhanced disruption of avoidance responding) enhanced subsequent olanzapine sensitivity, whereas the olanzapine (1.0 mg/kg)-induced sensitization had little impact on later RA treatment. When RA and olanzapine (0.5 mg/kg, subcutaneously) were used together, the RA-induced sensitization was still detectable in the RA challenge test, although its magnitude was reduced by olanzapine. Finally, we showed that the RA-induced sensitization in avoidance suppression persisted from adolescence into adulthood, long after such a treatment was terminated. Conclusions: These findings demonstrate that the RA is functionally equivalent (if not superior) to antipsychotic treatment in the avoidance suppression effect (both acute and sensitization effects) in both adolescent and adult animals. Behavioral therapies that specifically target the reinforcer of psychotic thoughts might be a viable strategy for the treatment of psychosis.

KeywordConditioned Avoidance Response Olanzapine Reinforcement Attenuation Extinction Antipsychotic Sensitization
DOI10.1177/0269881118805497
Indexed BySCI
Language英语
Funding ProjectNational Institute of Mental Health[5R01MH097718-02] ; National Natural Science Foundation of China (NSFC)[31500891] ; Fundamental Research Funds for the Central Universities[SWU1609131] ; Fundamental Research Funds for the Central Universities[SWU115030] ; Fundamental Research Funds for the Central Universities[SWU116014] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016G03] ; Chongqing Collaborative Innovation Center for Brain Science, China
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000456403900008
PublisherSAGE PUBLICATIONS LTD
WOS KeywordAntipsychotic-induced Sensitization ; Dopamine-d-2 Receptor Occupancy ; Risperidone Treatment ; Clozapine Treatment ; Linking Biology ; Animal-models ; Time-course ; Reward ; Schizophrenia ; Extinction
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28207
Collection中国科学院心理健康重点实验室
Corresponding AuthorGao, Jun; Li, Ming
Affiliation1.Southwest Univ, Fac Psychol, 2 Rd Tiansheng, Chongqing, Peoples R China
2.Southwest Univ, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
4.Chongqing Collaborat Innovat Ctr Brain Sci, Chongqing, Peoples R China
5.Univ Nebraska, Dept Psychol, 238 Burnett Hall, Lincoln, NE 68588 USA
Recommended Citation
GB/T 7714
Gao, Jun,Li, Ming. Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2019,33(1):86-100.
APA Gao, Jun,&Li, Ming.(2019).Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine.JOURNAL OF PSYCHOPHARMACOLOGY,33(1),86-100.
MLA Gao, Jun,et al."Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine".JOURNAL OF PSYCHOPHARMACOLOGY 33.1(2019):86-100.
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