PSYCH OpenIR  > 中国科学院心理健康重点实验室
Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition
Taaffe, Dennis R.1,2,3; Galvao, Daniel A.1,2; Spry, Nigel1,4,5; Joseph, David1,5,6; Chambers, Suzanne K.1,7,8,9; Gardiner, Robert A.1,10,11; Hayne, Dickon12,13; Cormie, Prue14; Shum, David H. K.7,15; Newton, Robert U.1,2,3,16
First AuthorDennis R. Taaffe
2019-02-01
Source PublicationBJU INTERNATIONAL
ISSN1464-4096
SubtypeArticle
Volume123Issue:2Pages:261-269
Abstract

Objectives To examine whether it is more efficacious to commence exercise medicine in men with prostate cancer at the onset of androgen-deprivation therapy (ADT) rather than later on during treatment to preserve bone and soft-tissue composition, as ADT results in adverse effects including: reduced bone mineral density (BMD), loss of muscle mass, and increased fat mass (FM). Patients and methods In all, 104 patients with prostate cancer, aged 48-84 years initiating ADT, were randomised to immediate exercise (IMEX, n = 54) or delayed exercise (DEL, n = 50) conditions. The former consisted of 6 months of supervised resistance/aerobic/impact exercise and the latter comprised 6 months of usual care followed by 6 months of the identical exercise programme. Regional and whole body BMD, lean mass (LM), whole body FM and trunk FM, and appendicular skeletal muscle (ASM) were assessed by dual X-ray absorptiometry, and muscle density by peripheral quantitative computed tomography at baseline, and at 6 and 12 months. Results There was a significant time effect (P < 0.001) for whole body, spine and hip BMD with a progressive loss in the IMEX and DEL groups, although lumbar spine BMD was largely preserved in the IMEX group at 6 months compared with the DEL group (-0.4% vs -1.6%). LM, ASM, and muscle density were preserved in the IMEX group at 6 months, declined in the DEL group at 6 months (-1.4% to -2.5%) and then recovered at 12 months after training. FM and trunk FM increased (P < 0.001) over the 12-month period in the IMEX (7.8% and 4.5%, respectively) and DEL groups (6.5% and 4.3%, respectively). Conclusions Commencing exercise at the onset of ADT preserves lumbar spine BMD, muscle mass, and muscle density. To avoid treatment-related adverse musculoskeletal effects, exercise medicine should be prescribed and commenced at the onset of ADT.

KeywordExercise Androgen-deprivation Therapy #pcsm #prostatecancer
DOI10.1111/bju.14505
Indexed BySCI
Language英语
Funding ProjectAustralian Research Council ; Cancer Council Western Australia Research Fellowship ; Beyond Blue (NHMRC)[1029901] ; Prostate Cancer Foundation of Australia ; Cancer Australia ; Cancer Australia ; Prostate Cancer Foundation of Australia ; Beyond Blue (NHMRC)[1029901] ; Cancer Council Western Australia Research Fellowship ; Australian Research Council
WOS Research AreaUrology & Nephrology
WOS SubjectUrology & Nephrology
WOS IDWOS:000456215500013
PublisherWILEY
WOS KeywordProstate-cancer Patients ; Quality-of-life ; Mineral Density ; Aerobic Exercise ; Muscle Mass ; Therapy ; Resistance ; Suppression ; Fat ; Sarcopenia
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28210
Collection中国科学院心理健康重点实验室
Corresponding AuthorTaaffe, Dennis R.
Affiliation1.Edith Cowan Univ, Exercise Med Res Inst, Joondalup, WA 6027, Australia
2.Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia
3.Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia
4.Genesis CancerCare, Joondalup, Australia
5.Univ Western Australia, Fac Med, Nedlands, WA, Australia
6.Sir Charles Gairdner Hosp, Dept Radiat Oncol, Nedlands, WA, Australia
7.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia
8.Canc Council, Ctr Res Canc, Brisbane, Qld, Australia
9.Prostate Canc Fdn Australia, Sydney, NSW, Australia
10.Royal Brisbane & Womens Hosp, Dept Urol, Brisbane, Qld, Australia
11.Univ Queensland, Ctr Clin Res, Brisbane, Qld, Australia
12.Univ Western Australia, UWA Med Sch, Crawley, Australia
13.Fiona Stanley Hosp, Murdoch, WA, Australia
14.Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia
15.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
16.Univ Hong Kong, Inst Human Performance, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Taaffe, Dennis R.,Galvao, Daniel A.,Spry, Nigel,et al. Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition[J]. BJU INTERNATIONAL,2019,123(2):261-269.
APA Taaffe, Dennis R..,Galvao, Daniel A..,Spry, Nigel.,Joseph, David.,Chambers, Suzanne K..,...&Newton, Robert U..(2019).Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition.BJU INTERNATIONAL,123(2),261-269.
MLA Taaffe, Dennis R.,et al."Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition".BJU INTERNATIONAL 123.2(2019):261-269.
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