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Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism
Xia, Haisen1; Du, Xiangdong2; Yin, Guangzhong2; Zhang, Yingyang2; Li, Xiaosi1; Cai, Junyi3; Huang, Xingbing3; Ning, Yuping3; Soares, Jair C.4; Wu, Fengchun3; Zhang, Xiang Yang5
First AuthorHaisen Xia
2019-01-18
Source PublicationSCIENTIFIC REPORTS
Correspondent Email13580380071@163.com ; zhangxy@psych.ac.cn
ISSN2045-2322
SubtypeArticle
Volume9Pages:9
Contribution Rank5
Abstract

Recent studies demonstrate that brain-derived neurotrophic factor (BDNF) might be associated with nicotine addiction, and circulating BDNF is a biomarker of memory and general cognitive function. Moreover, studies suggest that a functional polymorphism of the BDNF Val66Met may mediate hippocampal-dependent cognitive functions. We aimed to explore the relationships between smoking, cognitive performance and BDNF in a normal Chinese Han population. We recruited 628 male healthy subjects, inducing 322 smokers and 306 nonsmokers, and genotyped them the BDNF Val66Met polymorphism. Of these, we assessed 114 smokers and 98 nonsmokers on the repeatable battery for the assessment of neuropsychological status (RBANS), and 103 smokers and 89 nonsmokers on serum BDNF levels. Smokers scored lower than the nonsmokers on RBANS total score (p = 0.002), immediate memory (p = 0.003) and delayed memory (p = 0.021). BDNF levels among the smokers who were Val allele carriers were correlated with the degree of cognitive impairments, especially attention, as well as with the carbon monoxide concentrations. Our findings suggest that smoking is associated with cognitive impairment in a male Chinese Han population. The association between higher BDNF levels and cognitive impairment, mainly attention in smokers appears to be dependent on the BDNF Val66Met polymorphism.

DOI10.1038/s41598-018-36419-8
Indexed BySCI
Language英语
Funding ProjectJiangsu Province Natural Science Fund Project[BK20151197] ; Suzhou Key Diagnosis and Treatment Program[LCZX201316] ; Suzhou Key Project (Psychiatry)[Szxk201515] ; Science and Technology Program of Guangzhou[201807010064] ; Science and Technology Program of Guangzhou[201704020168] ; Science and Technology Program of Guangdong[2016A020216004] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Science and Technology Program of Guangdong[2016A020216004] ; Science and Technology Program of Guangzhou[201704020168] ; Science and Technology Program of Guangzhou[201807010064] ; Suzhou Key Project (Psychiatry)[Szxk201515] ; Suzhou Key Diagnosis and Treatment Program[LCZX201316] ; Jiangsu Province Natural Science Fund Project[BK20151197]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000456008900015
PublisherNATURE PUBLISHING GROUP
WOS KeywordNeurotrophic Factor Bdnf ; Activity-dependent Secretion ; Factor Messenger-rna ; Val(66)Met Polymorphism ; Cigarette-smoking ; Tobacco Smoking ; Nicotine Dependence ; Human-memory ; Association ; Serum
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28220
Collection健康与遗传心理学研究室
Corresponding AuthorWu, Fengchun; Zhang, Xiang Yang
Affiliation1.Hefei Fourth Peoples Hosp, Anhui Mental Hlth Ctr, Hefei, Anhui, Peoples R China
2.Soochow Univ, Suzhou Psychiat Hosp, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China
3.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Huiai Hosp, Guangzhou, Guangdong, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Xia, Haisen,Du, Xiangdong,Yin, Guangzhong,et al. Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism[J]. SCIENTIFIC REPORTS,2019,9:9.
APA Xia, Haisen.,Du, Xiangdong.,Yin, Guangzhong.,Zhang, Yingyang.,Li, Xiaosi.,...&Zhang, Xiang Yang.(2019).Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism.SCIENTIFIC REPORTS,9,9.
MLA Xia, Haisen,et al."Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism".SCIENTIFIC REPORTS 9(2019):9.
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