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The association of plasma peroxiredoxin 3 with insulin in pregnant women
Wang, Li1; Hao, Jun-Mei2; Yu, Ai-Qun3,4; Li, Tian-Tian5; Liu, Ran-Ran5; Li, Lianqin5; Li, Jingmin6; Li, Xiaoyan6
第一作者Wang, Li
通讯作者邮箱lilq2005@126.com ; li111-002@163.com
摘要

Peroxiredoxin 3 (PRX3) is predominantly located in mitochondria and plays a major role in scavenging hydrogen peroxide of mitochondria. In the present study, we detected plasma PRX3 in pregnant women receiving oral glucose tolerance test at 24-28 gestational weeks. Plasma PRX3 was significantly increased about 1 h later than insulin secretion. In vitro detection of PRX3 in mouse islet cells showed up-regulation by more than 2-fold at 1 h and reached its top at 2 h of glucose stimulation, and the PRX3 level in cultured mediums was concomitantly elevated in a glucose concentration-dependent manner. In addition, both fasting plasma insulin and PRX3 were significantly higher in the subjects of term pregnancy as compared to that at 24-28 gestational weeks, and there was a positive correlation between plasma PRX3 and insulin. Our results indicate that PRX3 plays an active role in the response to insulin release. The positive association of plasma PRX3 and insulin suggest PRX3 to be a potential indicator of high insulin resistance. (C) 2018 Elsevier Inc. All rights reserved.

关键词Peroxiredoxin Oxidative Stress Gestational Diabetes Mellitus Insulin Resistance
2019-01-15
语种英语
DOI10.1016/j.bbrc.2018.12.021
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (IF:3.100[JCR-2022],3.200[5-Year])
ISSN0006-291X
卷号508期号:3页码:805-810
期刊论文类型Article
收录类别SCI
资助项目Medical Science & Technology Development Program of Shandong Province[2015WS0478] ; Scientific Research Foundation of Binzhou Medical University[BY2015KYQD28]
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词Gestational Diabetes-mellitus ; Acute Psychological Stress ; Cysteine Sulfinic Acid ; Oxidative Stress ; Glucose-tolerance ; Antioxidant Defense ; 4 Protects ; Hyperglycemia ; Secretion ; Model
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000456492000022
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://ir.psych.ac.cn/handle/311026/28226
专题健康与遗传心理学研究室
通讯作者Li, Lianqin; Li, Xiaoyan
作者单位1.Binzhou Med Univ, Dept Obstet, Yantai Affiliated Hosp, Yantai 264100, Peoples R China
2.Binzhou Med Univ, Dept Pathol, Yantai Affiliated Hosp, Yantai 264100, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
5.Binzhou Med Univ, Yantai Affiliated Hosp, Dept Reprod Med, 717 Jinbu St, Muping Dist 264100, Yantai, Peoples R China
6.Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Laishan Dist 264003, Yantai, Peoples R China
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Wang, Li,Hao, Jun-Mei,Yu, Ai-Qun,et al. The association of plasma peroxiredoxin 3 with insulin in pregnant women[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019,508(3):805-810.
APA Wang, Li.,Hao, Jun-Mei.,Yu, Ai-Qun.,Li, Tian-Tian.,Liu, Ran-Ran.,...&Li, Xiaoyan.(2019).The association of plasma peroxiredoxin 3 with insulin in pregnant women.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,508(3),805-810.
MLA Wang, Li,et al."The association of plasma peroxiredoxin 3 with insulin in pregnant women".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 508.3(2019):805-810.
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