The association of plasma peroxiredoxin 3 with insulin in pregnant women | |
Wang, Li1![]() ![]() | |
第一作者 | Wang, Li |
通讯作者邮箱 | lilq2005@126.com ; li111-002@163.com |
摘要 | Peroxiredoxin 3 (PRX3) is predominantly located in mitochondria and plays a major role in scavenging hydrogen peroxide of mitochondria. In the present study, we detected plasma PRX3 in pregnant women receiving oral glucose tolerance test at 24-28 gestational weeks. Plasma PRX3 was significantly increased about 1 h later than insulin secretion. In vitro detection of PRX3 in mouse islet cells showed up-regulation by more than 2-fold at 1 h and reached its top at 2 h of glucose stimulation, and the PRX3 level in cultured mediums was concomitantly elevated in a glucose concentration-dependent manner. In addition, both fasting plasma insulin and PRX3 were significantly higher in the subjects of term pregnancy as compared to that at 24-28 gestational weeks, and there was a positive correlation between plasma PRX3 and insulin. Our results indicate that PRX3 plays an active role in the response to insulin release. The positive association of plasma PRX3 and insulin suggest PRX3 to be a potential indicator of high insulin resistance. (C) 2018 Elsevier Inc. All rights reserved. |
关键词 | Peroxiredoxin Oxidative Stress Gestational Diabetes Mellitus Insulin Resistance |
2019-01-15 | |
语种 | 英语 |
DOI | 10.1016/j.bbrc.2018.12.021 |
发表期刊 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (IF:3.100[JCR-2022],3.200[5-Year]) |
ISSN | 0006-291X |
卷号 | 508期号:3页码:805-810 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | Medical Science & Technology Development Program of Shandong Province[2015WS0478] ; Scientific Research Foundation of Binzhou Medical University[BY2015KYQD28] |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS关键词 | Gestational Diabetes-mellitus ; Acute Psychological Stress ; Cysteine Sulfinic Acid ; Oxidative Stress ; Glucose-tolerance ; Antioxidant Defense ; 4 Protects ; Hyperglycemia ; Secretion ; Model |
WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
WOS记录号 | WOS:000456492000022 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://ir.psych.ac.cn/handle/311026/28226 |
专题 | 健康与遗传心理学研究室 |
通讯作者 | Li, Lianqin; Li, Xiaoyan |
作者单位 | 1.Binzhou Med Univ, Dept Obstet, Yantai Affiliated Hosp, Yantai 264100, Peoples R China 2.Binzhou Med Univ, Dept Pathol, Yantai Affiliated Hosp, Yantai 264100, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 5.Binzhou Med Univ, Yantai Affiliated Hosp, Dept Reprod Med, 717 Jinbu St, Muping Dist 264100, Yantai, Peoples R China 6.Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Laishan Dist 264003, Yantai, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Li,Hao, Jun-Mei,Yu, Ai-Qun,et al. The association of plasma peroxiredoxin 3 with insulin in pregnant women[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019,508(3):805-810. |
APA | Wang, Li.,Hao, Jun-Mei.,Yu, Ai-Qun.,Li, Tian-Tian.,Liu, Ran-Ran.,...&Li, Xiaoyan.(2019).The association of plasma peroxiredoxin 3 with insulin in pregnant women.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,508(3),805-810. |
MLA | Wang, Li,et al."The association of plasma peroxiredoxin 3 with insulin in pregnant women".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 508.3(2019):805-810. |
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