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The association of plasma peroxiredoxin 3 with insulin in pregnant women
Wang, Li1; Hao, Jun-Mei2; Yu, Ai-Qun3,4; Li, Tian-Tian5; Liu, Ran-Ran5; Li, Lianqin5; Li, Jingmin6; Li, Xiaoyan6
First AuthorWang, Li
2019-01-15
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Correspondent Emaillilq2005@126.com ; li111-002@163.com
ISSN0006-291X
SubtypeArticle
Volume508Issue:3Pages:805-810
Abstract

Peroxiredoxin 3 (PRX3) is predominantly located in mitochondria and plays a major role in scavenging hydrogen peroxide of mitochondria. In the present study, we detected plasma PRX3 in pregnant women receiving oral glucose tolerance test at 24-28 gestational weeks. Plasma PRX3 was significantly increased about 1 h later than insulin secretion. In vitro detection of PRX3 in mouse islet cells showed up-regulation by more than 2-fold at 1 h and reached its top at 2 h of glucose stimulation, and the PRX3 level in cultured mediums was concomitantly elevated in a glucose concentration-dependent manner. In addition, both fasting plasma insulin and PRX3 were significantly higher in the subjects of term pregnancy as compared to that at 24-28 gestational weeks, and there was a positive correlation between plasma PRX3 and insulin. Our results indicate that PRX3 plays an active role in the response to insulin release. The positive association of plasma PRX3 and insulin suggest PRX3 to be a potential indicator of high insulin resistance. (C) 2018 Elsevier Inc. All rights reserved.

KeywordPeroxiredoxin Oxidative Stress Gestational Diabetes Mellitus Insulin Resistance
DOI10.1016/j.bbrc.2018.12.021
Indexed BySCI
Language英语
Funding ProjectScientific Research Foundation of Binzhou Medical University[BY2015KYQD28] ; Medical Science & Technology Development Program of Shandong Province[2015WS0478] ; Medical Science & Technology Development Program of Shandong Province[2015WS0478] ; Scientific Research Foundation of Binzhou Medical University[BY2015KYQD28]
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000456492000022
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
WOS KeywordGestational Diabetes-mellitus ; Acute Psychological Stress ; Cysteine Sulfinic Acid ; Oxidative Stress ; Glucose-tolerance ; Antioxidant Defense ; 4 Protects ; Hyperglycemia ; Secretion ; Model
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28226
Collection健康与遗传心理学研究室
Corresponding AuthorLi, Lianqin; Li, Xiaoyan
Affiliation1.Binzhou Med Univ, Dept Obstet, Yantai Affiliated Hosp, Yantai 264100, Peoples R China
2.Binzhou Med Univ, Dept Pathol, Yantai Affiliated Hosp, Yantai 264100, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
5.Binzhou Med Univ, Yantai Affiliated Hosp, Dept Reprod Med, 717 Jinbu St, Muping Dist 264100, Yantai, Peoples R China
6.Binzhou Med Univ, Sch Basic Med Sci, 346,Guanhai Rd, Laishan Dist 264003, Yantai, Peoples R China
Recommended Citation
GB/T 7714
Wang, Li,Hao, Jun-Mei,Yu, Ai-Qun,et al. The association of plasma peroxiredoxin 3 with insulin in pregnant women[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019,508(3):805-810.
APA Wang, Li.,Hao, Jun-Mei.,Yu, Ai-Qun.,Li, Tian-Tian.,Liu, Ran-Ran.,...&Li, Xiaoyan.(2019).The association of plasma peroxiredoxin 3 with insulin in pregnant women.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,508(3),805-810.
MLA Wang, Li,et al."The association of plasma peroxiredoxin 3 with insulin in pregnant women".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 508.3(2019):805-810.
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