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Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment
Jia, Xiuqin1,2; Li, Ying3; Li, Kuncheng3,4; Liang, Peipeng5; Fu, Xiaolan1,6
First AuthorJia, Xiuqin
2019-01-10
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
Correspondent Emailppliang@cnu.edu.cn ; fuxl@psych.ac.cn
ISSN1663-4365
SubtypeArticle
Volume10Pages:9
Contribution Rank1
Abstract

Background: Mild cognitive impairment (MCI) frequently occurs in Parkinson's disease (PD). Neurovascular changes interact with neurodegenerative processes in PD. However, the deficits of cerebral blood flow (CBF) perfusion and the associated functional connectivity (FC) in PD patients with MCI (PD-MCI) remain unclear. Purpose: This study aimed to explore the specific neurovascular perfusion alterations in PD-MCI compared to PD with normal cognition (PD-NC) and healthy controls (HCs), and to further examine the resultant whole brain FC changes in the abnormal perfusion regions. Methods: Relative CBF (rCBF) was calculated using arterial spin labeling (ASL) in 54 patients with PD (27 patients with PD-NC and 27 patients with PD-MCI) and 25 HCs matched for age and gender ratio, who also underwent the structural MRI, resting-state functional MRI (rs-fMRI) and neuropsychological examinations. The gray matter (GM) changes in PD patients were analyzed using voxel-based morphometry (VBM). The alterations in rCBF perfusion and FC among groups were then analyzed respectively. Additionally, correlations between these alterations and neuropsychological performances were further examined. Results: Compared to HC, left caudate atrophy was detected in patients with PD. In comparison to both PD-NC and HC, patients with PD-MCI specifically exhibited hypoperfusion in the parietal memory network (PMN) in the precuneus (PCu) and decreased PCu-FC in the right striatum. Moreover, PCu perfusion and PCu-FC strengths in the right striatum were positively associated with memory performance in PD-MCI. Conclusions: These findings suggest that the posterior PMN dysfunction underlies memory deficits in PD-MCI.

KeywordParkinson's Disease With Mild Cognitive Impairment Parietal Memory Network Arterial Spin Labeling (Asl) Functional Connectivity (Fc) Precuneus
DOI10.3389/fnagi.2018.00427
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[61473196] ; National Natural Science Foundation of China[61621136008] ; National Natural Science Foundation of China[61672065] ; Beijing Talents Foundation[2016000021223TD07] ; China Postdoctoral Science Foundation[2015M570165] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding[ZYLX201609] ; Key Projects in the National Science and Technology Pillar Program[2012BAI10B04]
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000455391000001
PublisherFRONTIERS MEDIA SA
WOS KeywordParietal Memory Network ; Resting-state ; Functional Connectivity ; Gray-matter ; Cortical Hypoperfusion ; Perfusion ; Mri ; Patterns ; Quantification ; Single
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28229
Collection脑与认知科学国家重点实验室
Corresponding AuthorLiang, Peipeng; Fu, Xiaolan
Affiliation1.Chinese Acad Sci, Inst Psychol, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
2.Capital Med Univ, Beijing Chaoyang Hosp, Dept Radiol, Beijing, Peoples R China
3.Capital Med Univ, Anzhen Hosp, Dept Radiol, Beijing, Peoples R China
4.Beijing Key Lab MRI & Brain Informat, Beijing, Peoples R China
5.Capital Normal Univ, Sch Psychol, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Jia, Xiuqin,Li, Ying,Li, Kuncheng,et al. Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment[J]. FRONTIERS IN AGING NEUROSCIENCE,2019,10:9.
APA Jia, Xiuqin,Li, Ying,Li, Kuncheng,Liang, Peipeng,&Fu, Xiaolan.(2019).Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment.FRONTIERS IN AGING NEUROSCIENCE,10,9.
MLA Jia, Xiuqin,et al."Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment".FRONTIERS IN AGING NEUROSCIENCE 10(2019):9.
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