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GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction
Chen, Hong-Shu1; Gu, Li-Jia2,3; Yang, Yuan-Xiao4; Guo, Jian-You2,3,5
First AuthorHong-Shu Chen
Contribution Rank2

The Gan-Mai-Da-Zao (GMDZ) decoction is one of the most famous Chinese medicine prescriptions to treat emotional diseases in China. Here we examined the anxiolytic-like effects of the GMDZ decoction in mice. The mice were orally administered with GMDZ decoction (1, 2, and 4 g/kg, respectively) for 7 days, diazepam (2 mg/kg, p.o.) and buspirone (5 mg/kg, p.o.) were used as positive controls. Then, elevated plus maze (EPM) test, light/dark box (LDB) test, and marble burying (MB) test, open field (OF) test and rota-rod test were performed. We found that GMDZ treatment (2 and 4 g/kg) significantly increased the percentage of open arm entries and time spent on the open arms in EPM as compared to the control. GMDZ treatment also significantly increased the time spent in the light box and the number of light box entries in LDB and reduced the number of marbles buried in MB. Similarly to those observed with diazepam and buspirone. In contrast, GMDZ did not affect the locomotor activity in the OF and motor coordination in the rota-rod test. Furthermore, the anxiolytic-like effects induced by GMDZ were inhibited by the gamma-aminobutyric acid-A (GABA(1A)) receptor antagonist flumazenil and 5-hydroxytryptamine-1A (5-HT1A) receptor antagonist WAY-100635. These results showed that GMDZ possesses anxiolytic-like effects in animal models, and its mechanism of action might be modulated by 5-HT1A and GABA(A) receptors.

KeywordGan-mai-da-zoo Decoction Anxiolytic Elevated Plus Maze Light/dark Box Gaba(a) Receptor 5-ht1a Receptor
Indexed BySCI
Funding ProjectNational Natural Foundation of China[30800301] ; National Natural Foundation of China[31170992] ; National Natural Foundation of China[31371038] ; Zhejiang Province Administration of Traditional Chinese Medicine[2015ZA073] ; Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immunoregulation, Nanyang Institute of Technology[KFKT2018-1] ; Nanyang Institute of Technology
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000456231200001
WOS KeywordElevated Plus-maze ; Herbal Medicine ; Behavior ; Anxiety ; Disorders ; Stress ; Acid ; Rat
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Document Type期刊论文
Corresponding AuthorGuo, Jian-You
Affiliation1.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Hangzhou Med Coll, Hangzhou, Zhejiang, Peoples R China
5.Nanyang Inst Technol, Henan Key Lab Zhang Zhongjing Formulae & Herbs Im, Nanyang, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chen, Hong-Shu,Gu, Li-Jia,Yang, Yuan-Xiao,et al. GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction[J]. FRONTIERS IN NEUROSCIENCE,2019,12:11.
APA Chen, Hong-Shu,Gu, Li-Jia,Yang, Yuan-Xiao,&Guo, Jian-You.(2019).GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction.FRONTIERS IN NEUROSCIENCE,12,11.
MLA Chen, Hong-Shu,et al."GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction".FRONTIERS IN NEUROSCIENCE 12(2019):11.
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