Institutional Repository of Key Laboratory of Mental Health, CAS
GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction | |
Chen, Hong-Shu1; Gu, Li-Jia2,3; Yang, Yuan-Xiao4; Guo, Jian-You2,3,5 | |
第一作者 | Hong-Shu Chen |
通讯作者邮箱 | guojy@psych.ac.cn |
心理所单位排序 | 2 |
摘要 | The Gan-Mai-Da-Zao (GMDZ) decoction is one of the most famous Chinese medicine prescriptions to treat emotional diseases in China. Here we examined the anxiolytic-like effects of the GMDZ decoction in mice. The mice were orally administered with GMDZ decoction (1, 2, and 4 g/kg, respectively) for 7 days, diazepam (2 mg/kg, p.o.) and buspirone (5 mg/kg, p.o.) were used as positive controls. Then, elevated plus maze (EPM) test, light/dark box (LDB) test, and marble burying (MB) test, open field (OF) test and rota-rod test were performed. We found that GMDZ treatment (2 and 4 g/kg) significantly increased the percentage of open arm entries and time spent on the open arms in EPM as compared to the control. GMDZ treatment also significantly increased the time spent in the light box and the number of light box entries in LDB and reduced the number of marbles buried in MB. Similarly to those observed with diazepam and buspirone. In contrast, GMDZ did not affect the locomotor activity in the OF and motor coordination in the rota-rod test. Furthermore, the anxiolytic-like effects induced by GMDZ were inhibited by the gamma-aminobutyric acid-A (GABA(1A)) receptor antagonist flumazenil and 5-hydroxytryptamine-1A (5-HT1A) receptor antagonist WAY-100635. These results showed that GMDZ possesses anxiolytic-like effects in animal models, and its mechanism of action might be modulated by 5-HT1A and GABA(A) receptors. |
关键词 | Gan-mai-da-zoo Decoction Anxiolytic Elevated Plus Maze Light/dark Box Gaba(a) Receptor 5-ht1a Receptor |
2019-01-22 | |
语种 | 英语 |
DOI | 10.3389/fnins.2018.01043 |
发表期刊 | FRONTIERS IN NEUROSCIENCE |
ISSN | 1662-453X |
卷号 | 12页码:11 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | Nanyang Institute of Technology ; Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immunoregulation, Nanyang Institute of Technology[KFKT2018-1] ; Zhejiang Province Administration of Traditional Chinese Medicine[2015ZA073] ; National Natural Foundation of China[31371038] ; National Natural Foundation of China[31170992] ; National Natural Foundation of China[30800301] ; National Natural Foundation of China[30800301] ; National Natural Foundation of China[31170992] ; National Natural Foundation of China[31371038] ; Zhejiang Province Administration of Traditional Chinese Medicine[2015ZA073] ; Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immunoregulation, Nanyang Institute of Technology[KFKT2018-1] ; Nanyang Institute of Technology |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | Elevated Plus-maze ; Herbal Medicine ; Behavior ; Anxiety ; Disorders ; Stress ; Acid ; Rat |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000456231200001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/28250 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Guo, Jian-You |
作者单位 | 1.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Hangzhou Med Coll, Hangzhou, Zhejiang, Peoples R China 5.Nanyang Inst Technol, Henan Key Lab Zhang Zhongjing Formulae & Herbs Im, Nanyang, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Chen, Hong-Shu,Gu, Li-Jia,Yang, Yuan-Xiao,et al. GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction[J]. FRONTIERS IN NEUROSCIENCE,2019,12:11. |
APA | Chen, Hong-Shu,Gu, Li-Jia,Yang, Yuan-Xiao,&Guo, Jian-You.(2019).GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction.FRONTIERS IN NEUROSCIENCE,12,11. |
MLA | Chen, Hong-Shu,et al."GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction".FRONTIERS IN NEUROSCIENCE 12(2019):11. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
GABA and 5-HT System(2945KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论