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The Influence of Expectancy Level and Personal Characteristics on Placebo Effects: Psychological Underpinnings
Zhou, Lili1,2; Wei, Hue3; Zhang, Huijuan1,2; Li, Xiaoyun3; Bo, Cunju4; Wan, Li4; Lu, Xuejing1,2; Hu, Li1,2,3,4
第一作者Lili Zhou
通讯作者邮箱luxj@psych.ac.cn ; wanli5000cn@163.com
心理所单位排序1
摘要

Placebo effects benefit a wide range of clinical practice, which can be profoundly influenced by expectancy level and personal characteristics. However, research on the issue of whether these factors independently or interdependently affect the placebo effects is still in its infancy. Here, we adopted a 3-day between-subject placebo analgesia paradigm (2-day conditioning and 1-day test) to investigate the influence of expectancy levels (i.e., No, Low, and High) and personal characteristics (i.e., gender, dispositional optimism, and anxiety state) on placebo effects in 120 healthy participants (60 females). Our results showed that the reduction of pain intensity in the test phase was influenced by the interaction between expectancy and gender, as mainly reflected by greater reductions of pain intensity in females at Low expectancy level than females at No/High expectancy levels, and greater reductions of pain intensity in males than in females at High expectancy level. Additionally, the reduction of pain unpleasantness was not only modulated by the interaction between expectancy and gender, but also by the interaction between expectancy and dispositional optimism, as well as the interaction between expectancy and anxiety state. Specifically, participants who were more optimistic in Low expectancy group, or those who were less anxious in High expectancy group showed greater reductions of pain unpleasantness. To sum up, we emphasized on regulating the expectancy level individually based on the assessment of personal characteristics to maximize placebo effects in clinical conditions.

关键词expectancy placebo analgesia gender dispositional optimism anxiety state
2019-02-05
语种英语
DOI10.3389/fpsyt.2019.00020
发表期刊FRONTIERS IN PSYCHIATRY
ISSN1664-0640
卷号10页码:10
期刊论文类型Article
收录类别SCI
资助项目Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[KLMH2018ZG02] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX281007] ; Informatization Special Project of Chinese Academy of Sciences[XXH13506-306] ; National Natural Science Foundation of China[31701000] ; National Natural Science Foundation of China[31822025] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31671141] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[31701000] ; Informatization Special Project of Chinese Academy of Sciences[XXH13506-306] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX281007] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[KLMH2018ZG02]
出版者FRONTIERS MEDIA SA
WOS关键词DISPOSITIONAL OPTIMISM ; RESPONSE EXPECTANCIES ; CHINESE VERSION ; SEX-DIFFERENCES ; PAIN ; ANALGESIA ; EXPERIENCE ; GENDER ; LIFE ; EXPECTATIONS
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000457788500002
Q分类Q2
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/28323
专题中国科学院心理健康重点实验室
通讯作者Wan, Li; Lu, Xuejing
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Fac Psychol, Chongqing, Peoples R China
4.Guangzhou Med Univ, Dept Pain Management, State Key Clin Specialty Pain Med, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
第一作者单位中国科学院心理健康重点实验室
通讯作者单位中国科学院心理健康重点实验室
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GB/T 7714
Zhou, Lili,Wei, Hue,Zhang, Huijuan,et al. The Influence of Expectancy Level and Personal Characteristics on Placebo Effects: Psychological Underpinnings[J]. FRONTIERS IN PSYCHIATRY,2019,10:10.
APA Zhou, Lili.,Wei, Hue.,Zhang, Huijuan.,Li, Xiaoyun.,Bo, Cunju.,...&Hu, Li.(2019).The Influence of Expectancy Level and Personal Characteristics on Placebo Effects: Psychological Underpinnings.FRONTIERS IN PSYCHIATRY,10,10.
MLA Zhou, Lili,et al."The Influence of Expectancy Level and Personal Characteristics on Placebo Effects: Psychological Underpinnings".FRONTIERS IN PSYCHIATRY 10(2019):10.
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