PSYCH OpenIR  > 中国科学院心理健康重点实验室
The Influence of Expectancy Level and Personal Characteristics on Placebo Effects: Psychological Underpinnings
Zhou, Lili1,2; Wei, Hue3; Zhang, Huijuan1,2; Li, Xiaoyun3; Bo, Cunju4; Wan, Li4; Lu, Xuejing1,2; Hu, Li1,2,3,4
Corresponding AuthorWan, Li(wanli5000cn@163.com) ; Lu, Xuejing(luxj@psych.ac.cn)
2019-02-05
Source PublicationFRONTIERS IN PSYCHIATRY
ISSN1664-0640
Volume10Pages:10
AbstractPlacebo effects benefit a wide range of clinical practice, which can be profoundly influenced by expectancy level and personal characteristics. However, research on the issue of whether these factors independently or interdependently affect the placebo effects is still in its infancy. Here, we adopted a 3-day between-subject placebo analgesia paradigm (2-day conditioning and 1-day test) to investigate the influence of expectancy levels (i.e., No, Low, and High) and personal characteristics (i.e., gender, dispositional optimism, and anxiety state) on placebo effects in 120 healthy participants (60 females). Our results showed that the reduction of pain intensity in the test phase was influenced by the interaction between expectancy and gender, as mainly reflected by greater reductions of pain intensity in females at Low expectancy level than females at No/High expectancy levels, and greater reductions of pain intensity in males than in females at High expectancy level. Additionally, the reduction of pain unpleasantness was not only modulated by the interaction between expectancy and gender, but also by the interaction between expectancy and dispositional optimism, as well as the interaction between expectancy and anxiety state. Specifically, participants who were more optimistic in Low expectancy group, or those who were less anxious in High expectancy group showed greater reductions of pain unpleasantness. To sum up, we emphasized on regulating the expectancy level individually based on the assessment of personal characteristics to maximize placebo effects in clinical conditions.
Keywordexpectancy placebo analgesia gender dispositional optimism anxiety state
DOI10.3389/fpsyt.2019.00020
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Informatization Special Project of Chinese Academy of Sciences ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences
Funding ProjectNational Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31701000] ; National Natural Science Foundation of China[31822025] ; Informatization Special Project of Chinese Academy of Sciences[XXH13506-306] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX281007] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[KLMH2018ZG02]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000457788500002
PublisherFRONTIERS MEDIA SA
WOS KeywordDISPOSITIONAL OPTIMISM ; RESPONSE EXPECTANCIES ; CHINESE VERSION ; SEX-DIFFERENCES ; PAIN ; ANALGESIA ; EXPERIENCE ; GENDER ; LIFE ; EXPECTATIONS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28323
Collection中国科学院心理健康重点实验室
Corresponding AuthorWan, Li; Lu, Xuejing
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Fac Psychol, Chongqing, Peoples R China
4.Guangzhou Med Univ, Dept Pain Management, State Key Clin Specialty Pain Med, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhou, Lili,Wei, Hue,Zhang, Huijuan,et al. The Influence of Expectancy Level and Personal Characteristics on Placebo Effects: Psychological Underpinnings[J]. FRONTIERS IN PSYCHIATRY,2019,10:10.
APA Zhou, Lili.,Wei, Hue.,Zhang, Huijuan.,Li, Xiaoyun.,Bo, Cunju.,...&Hu, Li.(2019).The Influence of Expectancy Level and Personal Characteristics on Placebo Effects: Psychological Underpinnings.FRONTIERS IN PSYCHIATRY,10,10.
MLA Zhou, Lili,et al."The Influence of Expectancy Level and Personal Characteristics on Placebo Effects: Psychological Underpinnings".FRONTIERS IN PSYCHIATRY 10(2019):10.
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