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The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms | |
Li, Gen1,2,3; Zhang, Kunlin1,2,3; Wang, Li1,2,3; Cao, Chengqi1,2,4; Fang, Ruojiao1,2,3; Liu, Ping5; Luo, Shu5; Liberzon, Israel6,7,8 | |
第一作者 | Gen Li |
通讯作者邮箱 | zhangkl@psych.ac.cn (k. zhang) ; wangli1@psych.ac.cn (l. wang). |
心理所单位排序 | 1 |
摘要 | Orexigenic hormones are a group of hormones that can up-regulate appetite. Current studies have shown that orexigenic hormones also play important roles in stress responses and may be implicated in regulation of fear memory. However, these conclusions lack evidence from human studies. In this study, we examined associations between orexigenic hormone genes and fear-related mental disorders by investigating main, G x E, and G x G effects of ghrelin and orexin gene single nucleotide polymorphisms (SNPs) on human posttraumatic stress disorder (PTSD) symptoms in 1134 Chinese earthquake survivors. SNPs Leu72Met of the GHRL gene (rs696217), Ile408Val of the HCRTRI gene (rs2271933) and Val308Ile of the HCRTR2 gene (rs2653349) were genotyped. None of the SNPs showed significant main or G x E effects. However, a significant interaction effect between GHRL rs696217 and HCRTRI rs2271933 was found to predict the PTSD Checklist (PCL-5) total score (P = 0.007). Further analysis revealed different interaction patterns in males and females. For females, the rs2271933 G allele was associated with an increased PCL-5 total score (B = 2.59, P = 0.024) when the rs696217 genotype TT/TG was present. For males, the rs696217 T allele is associated with an increased PCL-5 total score (B =. 3.62, P = 0.040) when the rs2271933 genotype GG/GA was present. These current findings expand our knowledge of physiological function of the orexigenic hormone system, and suggest its involvement in development of fear related mental disorders such as PTSD. |
关键词 | Ghrelin Orexin Gene-gene interaction Fear PTSD |
2019-02-01 | |
语种 | 英语 |
DOI | 10.1016/j.psyneuen.2018.09.042 |
发表期刊 | PSYCHONEUROENDOCRINOLOGY |
ISSN | 0306-4530 |
卷号 | 100页码:131-136 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | Beijing Municipal Science and Technology Commission[171100000117014] ; National Natural Science Foundation of China[31470070] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31271099] |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS关键词 | GHRELIN GENE ; LEU72MET POLYMORPHISM ; GROWTH-HORMONE ; SLEEP ; METABOLISM ; PEPTIDE ; NEURONS ; OREXINS ; SYSTEM |
WOS研究方向 | Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry |
WOS类目 | Endocrinology & Metabolism ; Neurosciences ; Psychiatry |
WOS记录号 | WOS:000457820600019 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/28332 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Kunlin; Wang, Li |
作者单位 | 1.Inst Psychol, Lab Traumat Stress Studies, Beijing, Peoples R China 2.Inst Psychol, Ctr Genet & BioMed Informat Res, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China 5.Peoples Hosp Deyang City, Deyang, Sichuan, Peoples R China 6.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA 7.VA Ann Arbor Healthcare Syst, Mental Hlth Serv, Ann Arbor, MI USA 8.Univ Michigan, Dept Psychol, Ann Arbor, MI USA |
推荐引用方式 GB/T 7714 | Li, Gen,Zhang, Kunlin,Wang, Li,et al. The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms[J]. PSYCHONEUROENDOCRINOLOGY,2019,100:131-136. |
APA | Li, Gen.,Zhang, Kunlin.,Wang, Li.,Cao, Chengqi.,Fang, Ruojiao.,...&Liberzon, Israel.(2019).The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.PSYCHONEUROENDOCRINOLOGY,100,131-136. |
MLA | Li, Gen,et al."The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms".PSYCHONEUROENDOCRINOLOGY 100(2019):131-136. |
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