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The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms
Li, Gen1,2,3; Zhang, Kunlin1,2,3; Wang, Li1,2,3; Cao, Chengqi1,2,4; Fang, Ruojiao1,2,3; Liu, Ping5; Luo, Shu5; Liberzon, Israel6,7,8
First AuthorGen Li
2019-02-01
Source PublicationPSYCHONEUROENDOCRINOLOGY
Correspondent Emailzhangkl@psych.ac.cn (k. zhang) ; wangli1@psych.ac.cn (l. wang).
ISSN0306-4530
SubtypeArticle
Volume100Pages:131-136
Contribution Rank1
Abstract

Orexigenic hormones are a group of hormones that can up-regulate appetite. Current studies have shown that orexigenic hormones also play important roles in stress responses and may be implicated in regulation of fear memory. However, these conclusions lack evidence from human studies. In this study, we examined associations between orexigenic hormone genes and fear-related mental disorders by investigating main, G x E, and G x G effects of ghrelin and orexin gene single nucleotide polymorphisms (SNPs) on human posttraumatic stress disorder (PTSD) symptoms in 1134 Chinese earthquake survivors. SNPs Leu72Met of the GHRL gene (rs696217), Ile408Val of the HCRTRI gene (rs2271933) and Val308Ile of the HCRTR2 gene (rs2653349) were genotyped. None of the SNPs showed significant main or G x E effects. However, a significant interaction effect between GHRL rs696217 and HCRTRI rs2271933 was found to predict the PTSD Checklist (PCL-5) total score (P = 0.007). Further analysis revealed different interaction patterns in males and females. For females, the rs2271933 G allele was associated with an increased PCL-5 total score (B = 2.59, P = 0.024) when the rs696217 genotype TT/TG was present. For males, the rs696217 T allele is associated with an increased PCL-5 total score (B =. 3.62, P = 0.040) when the rs2271933 genotype GG/GA was present. These current findings expand our knowledge of physiological function of the orexigenic hormone system, and suggest its involvement in development of fear related mental disorders such as PTSD.

KeywordGhrelin Orexin Gene-gene interaction Fear PTSD
DOI10.1016/j.psyneuen.2018.09.042
Indexed BySCI
Language英语
Funding ProjectBeijing Municipal Science and Technology Commission[171100000117014] ; National Natural Science Foundation of China[31470070] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31271099]
WOS Research AreaEndocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
WOS SubjectEndocrinology & Metabolism ; Neurosciences ; Psychiatry
WOS IDWOS:000457820600019
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordGHRELIN GENE ; LEU72MET POLYMORPHISM ; GROWTH-HORMONE ; SLEEP ; METABOLISM ; PEPTIDE ; NEURONS ; OREXINS ; SYSTEM
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28332
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Kunlin; Wang, Li
Affiliation1.Inst Psychol, Lab Traumat Stress Studies, Beijing, Peoples R China
2.Inst Psychol, Ctr Genet & BioMed Informat Res, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China
5.Peoples Hosp Deyang City, Deyang, Sichuan, Peoples R China
6.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
7.VA Ann Arbor Healthcare Syst, Mental Hlth Serv, Ann Arbor, MI USA
8.Univ Michigan, Dept Psychol, Ann Arbor, MI USA
Recommended Citation
GB/T 7714
Li, Gen,Zhang, Kunlin,Wang, Li,et al. The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms[J]. PSYCHONEUROENDOCRINOLOGY,2019,100:131-136.
APA Li, Gen.,Zhang, Kunlin.,Wang, Li.,Cao, Chengqi.,Fang, Ruojiao.,...&Liberzon, Israel.(2019).The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.PSYCHONEUROENDOCRINOLOGY,100,131-136.
MLA Li, Gen,et al."The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms".PSYCHONEUROENDOCRINOLOGY 100(2019):131-136.
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