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Neural indicators of perceptual variability of pain across species
Hu, L.1,2; Iannetti, G. D.3,4
First AuthorL. Hu
2019-01-29
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
SubtypeArticle
Volume116Issue:5Pages:1782-1791
Contribution Rank1
Abstract

Individuals exhibit considerable and unpredictable variability in painful percepts in response to the same nociceptive stimulus. Previous work has found neural responses that, while not necessarily responsible for the painful percepts themselves, can still correlate well with intensity of pain perception within a given individual. However, there is no reliable neural response reflecting the variability in pain perception across individuals. Here, we use an electrophysiological approach in humans and rodents to demonstrate that brain oscillations in the gamma band [gamma-band event-related synchronization (gamma-ERS)] sampled by central electrodes reliably predict pain sensitivity across individuals. We observed a clear dissociation between the large number of neural measures that reflected subjective pain ratings at within-subject level but not across individuals, and gamma-ERS, which reliably distinguished subjective ratings within the same individual but also coded pain sensitivity across different individuals. Importantly, the ability of gamma-ERS to track pain sensitivity across individuals was selective because it did not track the between-subject reported intensity of nonpainful but equally salient auditory, visual, and nonnociceptive somatosensory stimuli. These results also demonstrate that graded neural activity related to within-subject variability should be minimized to accurately investigate the relationship between nociceptive-evoked neural activities and pain sensitivity across individuals.

Keywordpain individual variability gamma oscillations neural marker human
DOI10.1073/pnas.1812499116
Indexed BySCI
Language英语
Funding ProjectParis Institute of Advanced Studies (France) ; Wellcome Trust (COLL JLARAXR) ; European Research Council (CoG PAINSTRAT) ; Informatization Special Project of Chinese Academy of Sciences[XXH13506-306] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[31671141]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000456944600051
PublisherNATL ACAD SCIENCES
WOS KeywordINDIVIDUAL-DIFFERENCES ; EEG RESPONSES ; HUMAN BRAIN ; C-FIBER ; A-DELTA ; OSCILLATIONS ; REFLECT ; STIMULATION ; SENSITIVITY ; MODULATION
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28338
Collection中国科学院心理健康重点实验室
Corresponding AuthorHu, L.; Iannetti, G. D.
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Ist Italiano Tecnol, Neurosci & Behav Lab, I-00161 Rome, Italy
4.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
Recommended Citation
GB/T 7714
Hu, L.,Iannetti, G. D.. Neural indicators of perceptual variability of pain across species[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(5):1782-1791.
APA Hu, L.,&Iannetti, G. D..(2019).Neural indicators of perceptual variability of pain across species.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(5),1782-1791.
MLA Hu, L.,et al."Neural indicators of perceptual variability of pain across species".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.5(2019):1782-1791.
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