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Neural indicators of perceptual variability of pain across species
Hu, L.1,2; Iannetti, G. D.3,4
通讯作者Hu, L.(huli@psych.ac.cn) ; Iannetti, G. D.(g.iannetti@ucl.ac.uk)
2019-01-29
发表期刊PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
卷号116期号:5页码:1782-1791
摘要Individuals exhibit considerable and unpredictable variability in painful percepts in response to the same nociceptive stimulus. Previous work has found neural responses that, while not necessarily responsible for the painful percepts themselves, can still correlate well with intensity of pain perception within a given individual. However, there is no reliable neural response reflecting the variability in pain perception across individuals. Here, we use an electrophysiological approach in humans and rodents to demonstrate that brain oscillations in the gamma band [gamma-band event-related synchronization (gamma-ERS)] sampled by central electrodes reliably predict pain sensitivity across individuals. We observed a clear dissociation between the large number of neural measures that reflected subjective pain ratings at within-subject level but not across individuals, and gamma-ERS, which reliably distinguished subjective ratings within the same individual but also coded pain sensitivity across different individuals. Importantly, the ability of gamma-ERS to track pain sensitivity across individuals was selective because it did not track the between-subject reported intensity of nonpainful but equally salient auditory, visual, and nonnociceptive somatosensory stimuli. These results also demonstrate that graded neural activity related to within-subject variability should be minimized to accurately investigate the relationship between nociceptive-evoked neural activities and pain sensitivity across individuals.
关键词pain individual variability gamma oscillations neural marker human
DOI10.1073/pnas.1812499116
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China ; Informatization Special Project of Chinese Academy of Sciences ; European Research Council (CoG PAINSTRAT) ; Wellcome Trust (COLL JLARAXR) ; Paris Institute of Advanced Studies (France)
资助项目National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31822025] ; Informatization Special Project of Chinese Academy of Sciences[XXH13506-306] ; European Research Council (CoG PAINSTRAT) ; Wellcome Trust (COLL JLARAXR) ; Paris Institute of Advanced Studies (France)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000456944600051
出版者NATL ACAD SCIENCES
关键词[WOS]INDIVIDUAL-DIFFERENCES ; EEG RESPONSES ; HUMAN BRAIN ; C-FIBER ; A-DELTA ; OSCILLATIONS ; REFLECT ; STIMULATION ; SENSITIVITY ; MODULATION
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/28338
专题中国科学院心理健康重点实验室
通讯作者Hu, L.; Iannetti, G. D.
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Ist Italiano Tecnol, Neurosci & Behav Lab, I-00161 Rome, Italy
4.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
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GB/T 7714
Hu, L.,Iannetti, G. D.. Neural indicators of perceptual variability of pain across species[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(5):1782-1791.
APA Hu, L.,&Iannetti, G. D..(2019).Neural indicators of perceptual variability of pain across species.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(5),1782-1791.
MLA Hu, L.,et al."Neural indicators of perceptual variability of pain across species".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.5(2019):1782-1791.
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