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Anxious brain networks: A coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety
Xu, Jie1; Van Dam, Nicholas T.2,3; Feng, Chunliang1,4; Luo, Yuejia1,5; Ai, Hui1,5; Gu, Ruolei6,7; Xu, Pengfei1,5,8
Corresponding AuthorAi, Hui(h.ai@szu.edu.cn) ; Gu, Ruolei(gurl@psych.ac.cn) ; Xu, Pengfei(xupf@szu.edu.cn)
2019
Source PublicationNEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN0149-7634
Volume96Pages:21-30
AbstractAnxiety and anxiety disorders are associated with specific alterations to functional brain networks, including intra-networks and inter-networks. Given the heterogeneity within anxiety disorders and inconsistencies in functional network differences across studies, identifying common patterns of altered brain networks in anxiety is imperative. Here, we conducted an activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety and anxiety disorders (including 835 individuals with different levels of anxiety or anxiety disorders and 508 controls). Results show that anxiety can be characterized by hypo-connectivity of the affective network with executive control network (ECN) and default mode network (DMN), as well as de coupling of the ECN with the DMN. The connectivity within the salience network and its connectivity with sensorimotor network are also attenuated. These results reveal consistent dysregulations of affective and cognitive control related networks over networks related to emotion processing in anxiety and anxiety disorders. The current findings provide an empirical foundation for an integrated model of brain network alterations that are common across anxiety and anxiety disorders.
KeywordAnxiety Anxiety disorders Resting-state Functional brain networks Activation likelihood estimation Meta-analysis
DOI10.1016/j.neubiorev.2018.11.005
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Zhujiang Talent Project for Postdoctoral researchers, Guangdong young Innovative Talent Project ; Natural Science Foundation of Shenzhen University ; Shenzhen Science and Technology Research Funding Program ; Shenzhen Peacock Program
Funding ProjectNational Natural Science Foundation of China[31530031] ; National Natural Science Foundation of China[31500920] ; National Natural Science Foundation of China[31871137] ; National Natural Science Foundation of China[31571124] ; National Natural Science Foundation of China[81471376] ; National Natural Science Foundation of China[31700959] ; National Natural Science Foundation of China[31671133] ; National Basic Research Program of China (973 Program)[2014CB744600] ; National Basic Research Program of China (973 Program)[2011CB711000] ; Zhujiang Talent Project for Postdoctoral researchers, Guangdong young Innovative Talent Project[2016KQNCX149] ; Natural Science Foundation of Shenzhen University[85303[HYPHEN]00000275] ; Shenzhen Science and Technology Research Funding Program[JCYJ20170412164413575] ; Shenzhen Peacock Program[827[HYPHEN]000235] ; Shenzhen Peacock Program[KQTD2015033016104926]
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000457657300003
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordTRANSCRANIAL MAGNETIC STIMULATION ; VENTROMEDIAL PREFRONTAL CORTEX ; GENERALIZED ANXIETY ; PANIC DISORDER ; STRUCTURAL CONNECTIVITY ; EMOTION REGULATION ; POSTCENTRAL-GYRUS ; COGNITIVE CONTROL ; DECISION-MAKING ; NEURAL CIRCUITS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28341
Collection中国科学院行为科学重点实验室
Corresponding AuthorAi, Hui; Gu, Ruolei; Xu, Pengfei
Affiliation1.Shenzhen Univ, Shenzhen Key Lab Affect & Social Neurosci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China
2.Univ Melbourne, Sch Psychol Sci, Melbourne, Vic 3010, Australia
3.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
4.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China
5.Shenzhen Inst Neurosci, Ctr Emot & Brain, Shenzhen 518057, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beying 100049, Peoples R China
8.Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, NL-9713 AW Groningen, Netherlands
Recommended Citation
GB/T 7714
Xu, Jie,Van Dam, Nicholas T.,Feng, Chunliang,et al. Anxious brain networks: A coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2019,96:21-30.
APA Xu, Jie.,Van Dam, Nicholas T..,Feng, Chunliang.,Luo, Yuejia.,Ai, Hui.,...&Xu, Pengfei.(2019).Anxious brain networks: A coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,96,21-30.
MLA Xu, Jie,et al."Anxious brain networks: A coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 96(2019):21-30.
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