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Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner
Wang, Xingyue1,2; Qiao, Yanhua1,2; Dai, Zhonghua1,2; Sui, Nan1,2; Shen, Fang1,2; Zhang, Jianjun1,2; Liang, Jing1,2
First AuthorXingyue Wang
2019
Source PublicationBRAIN STRUCTURE & FUNCTION
Correspondent Emailjing liang liangj@psych.ac.cn
ISSN1863-2653
SubtypeArticle
Volume224Issue:1Pages:419-434
Contribution Rank1
Abstract

The striatum has been implicated in the regulation of cognitive flexibility. Abnormalities in the anterior dorsomedial striatum (aDMS) are revealed in many mental disorders in which cognitive inflexibility is commonly observed. However, it remains poorly understood whether the aDMS plays a special role in flexible cognitive control and what the regulation pattern is in different neuronal populations. Based on the reversal learning task in mice, we showed that optogenetic activation in dopamine receptor 1-expressing medium spiny neurons (D1R-MSNs) of the aDMS impaired flexibility; meanwhile, suppressing these neurons facilitated behavioral performance. Conversely, D2R-MSN activation accelerated reversal learning, but it induced no change through neuronal suppression. The acquisition and retention of discrimination learning were unaffected by the manipulation of any type of MSN. Through bi-direct optogenetic modulation in D1R-MSNs of the same subject in a serial reversal learning task, we further revealed the function of D1R-MSNs during different stages of reversal learning, where inhibiting and exciting the same group of neurons reduced perseverative errors and increased regressive errors. Following D1R- and D2R-MSN activation in the aDMS, neuronal activity of the mediodorsal thalamus decreased and increased, respectively, in parallel with behavioral impairment and facilitation, but not as a direct result of the activation of the striatal MSNs. We propose that D1R- and D2R-MSN sub-populations in the aDMS exert opposing functions in cognitive flexibility regulation, with more important and complex roles of D1R-MSNs involved. Mental disorders with cognitive flexibility problems may feature an underlying functional imbalance in the aDMS' two types of neurons.

KeywordAnterior dorsomedial striatum Behavioral flexibility Optogenetics Medium spiny neurons Dopamine receptors
DOI10.1007/s00429-018-1780-4
Indexed BySCI
Language英语
Funding ProjectNational Key Basic Research Program of China[2015CB553501] ; Beijing Natural Science Foundation[5162023] ; National Natural Science Foundation of China[31571108]
WOS Research AreaAnatomy & Morphology ; Neurosciences & Neurology
WOS SubjectAnatomy & Morphology ; Neurosciences
WOS IDWOS:000458286500027
PublisherSPRINGER HEIDELBERG
WOS KeywordBEHAVIORAL FLEXIBILITY ; BASAL GANGLIA ; PARKINSONS-DISEASE ; DORSAL STRIATUM ; DISTINCT ROLES ; VISUAL-DISCRIMINATION ; ORBITOFRONTAL CORTEX ; MEDIODORSAL THALAMUS ; NUCLEUS-ACCUMBENS ; INDIRECT PATHWAYS
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28353
Collection中国科学院心理健康重点实验室
Corresponding AuthorLiang, Jing
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xingyue,Qiao, Yanhua,Dai, Zhonghua,et al. Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner[J]. BRAIN STRUCTURE & FUNCTION,2019,224(1):419-434.
APA Wang, Xingyue.,Qiao, Yanhua.,Dai, Zhonghua.,Sui, Nan.,Shen, Fang.,...&Liang, Jing.(2019).Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner.BRAIN STRUCTURE & FUNCTION,224(1),419-434.
MLA Wang, Xingyue,et al."Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner".BRAIN STRUCTURE & FUNCTION 224.1(2019):419-434.
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