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PSYCH OpenIR  > 中国科学院心理健康重点实验室
Clinical utility of the dual n-back task in schizophrenia: A functional imaging approach
Li, Xu1,2,3; Yi, Zheng-hui4; Lv, Qin-yu4; Chu, Min-yi5; Hu, Hui-xin5; Wang, Jin-hong6; Zhang, Jian-ye6; Cheung, Eric E. F.7; Chan, Raymond C. K.2,3,5,8,9
第一作者Xu Li
通讯作者邮箱rckchan@psych.ac.cn (r.c.k. chan)
心理所单位排序2
摘要

The neural correlate of working memory (WM) impairment in schizophrenia is key to the understanding of the cognitive deficits observed in this disorder. We sought to determine the clinical validity of the dual version n-back paradigm in patients with schizophrenia, and whether schizophrenia patients exhibit altered brain activation patterns compared with healthy controls in this dual version WM measure using functional magnetic resonance imaging. Patients with schizophrenia (n = 20) and healthy controls (n = 24) performed the dual n-back task that consists of both visuospatial and auditory-verbal n-back streams, in which participants were required to monitor and update the contents from these two different inputs simultaneously. Significant positive correlations were found between performance in the dual 2-back condition and another measure of WM capacity and IQ estimates. Moreover, hypoactivation was observed at the right middle frontal gyrus and the posterior parietal regions in schizophrenia participants compared with healthy controls. The right hippocampus was less deactivated in schizophrenia patients compared with healthy controls. Our results support the clinical utility of the dual n-back task in schizophrenia and may have implications for the development of specific cognitive training targeting these impaired neural substrates in relation to WM in patients with schizophrenia.

关键词Working memory Dual n-back Schizophrenia Dorsolateral prefrontal cortex
2019-02-28
语种英语
DOI10.1016/j.pscychresns.2019.01.002
发表期刊PSYCHIATRY RESEARCH-NEUROIMAGING (IF:2.300[JCR-2022],2.500[5-Year])
ISSN0925-4927
卷号284页码:37-44
期刊论文类型Article
收录类别SCI
出版者ELSEVIER IRELAND LTD
WOS关键词DORSOLATERAL PREFRONTAL CORTEX ; WORKING-MEMORY PERFORMANCE ; METAANALYSIS ; DYSFUNCTION ; CAPACITY ; CONNECTIVITY ; INDIVIDUALS ; MAINTENANCE ; ACTIVATION ; COGNITION
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Clinical Neurology ; Neuroimaging ; Psychiatry
WOS记录号WOS:000459530500006
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://ir.psych.ac.cn/handle/311026/28389
专题中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Cent China Normal Univ, Sch Psychol, Key Lab Adolescent Cyberpsychol & Behav CCNU, Minist Educ, Wuhan, Hubei, Peoples R China
2.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China
5.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, Sch Med, Shanghai, Peoples R China
6.MRI Ctr, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
7.Castle Peak Hosp, Hong Kong, Peoples R China
8.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia
9.Griffith Univ, Sch Appl Psychol, Gold Coast, Australia
第一作者单位认知与发展心理学研究室
通讯作者单位认知与发展心理学研究室
推荐引用方式
GB/T 7714
Li, Xu,Yi, Zheng-hui,Lv, Qin-yu,et al. Clinical utility of the dual n-back task in schizophrenia: A functional imaging approach[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2019,284:37-44.
APA Li, Xu.,Yi, Zheng-hui.,Lv, Qin-yu.,Chu, Min-yi.,Hu, Hui-xin.,...&Chan, Raymond C. K..(2019).Clinical utility of the dual n-back task in schizophrenia: A functional imaging approach.PSYCHIATRY RESEARCH-NEUROIMAGING,284,37-44.
MLA Li, Xu,et al."Clinical utility of the dual n-back task in schizophrenia: A functional imaging approach".PSYCHIATRY RESEARCH-NEUROIMAGING 284(2019):37-44.
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