Institutional Repository of Key Laboratory of Mental Health, CAS
Clinical utility of the dual n-back task in schizophrenia: A functional imaging approach | |
Li, Xu1,2,3![]() ![]() | |
First Author | Xu Li |
Correspondent Email | rckchan@psych.ac.cn (r.c.k. chan) |
Contribution Rank | 2 |
Abstract | The neural correlate of working memory (WM) impairment in schizophrenia is key to the understanding of the cognitive deficits observed in this disorder. We sought to determine the clinical validity of the dual version n-back paradigm in patients with schizophrenia, and whether schizophrenia patients exhibit altered brain activation patterns compared with healthy controls in this dual version WM measure using functional magnetic resonance imaging. Patients with schizophrenia (n = 20) and healthy controls (n = 24) performed the dual n-back task that consists of both visuospatial and auditory-verbal n-back streams, in which participants were required to monitor and update the contents from these two different inputs simultaneously. Significant positive correlations were found between performance in the dual 2-back condition and another measure of WM capacity and IQ estimates. Moreover, hypoactivation was observed at the right middle frontal gyrus and the posterior parietal regions in schizophrenia participants compared with healthy controls. The right hippocampus was less deactivated in schizophrenia patients compared with healthy controls. Our results support the clinical utility of the dual n-back task in schizophrenia and may have implications for the development of specific cognitive training targeting these impaired neural substrates in relation to WM in patients with schizophrenia. |
Keyword | Working memory Dual n-back Schizophrenia Dorsolateral prefrontal cortex |
2019-02-28 | |
Language | 英语 |
DOI | 10.1016/j.pscychresns.2019.01.002 |
Source Publication | PSYCHIATRY RESEARCH-NEUROIMAGING
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ISSN | 0925-4927 |
Volume | 284Pages:37-44 |
Subtype | Article |
Indexed By | SCI |
Funding Project | National Science Fund China[31700957] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; National Key Research and Development Programme[2016YFC0906402] ; National Science Fund China[81571317] |
Publisher | ELSEVIER IRELAND LTD |
WOS Keyword | DORSOLATERAL PREFRONTAL CORTEX ; WORKING-MEMORY PERFORMANCE ; METAANALYSIS ; DYSFUNCTION ; CAPACITY ; CONNECTIVITY ; INDIVIDUALS ; MAINTENANCE ; ACTIVATION ; COGNITION |
WOS Research Area | Neurosciences & Neurology ; Psychiatry |
WOS Subject | Clinical Neurology ; Neuroimaging ; Psychiatry |
WOS ID | WOS:000459530500006 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/28389 |
Collection | 中国科学院心理健康重点实验室 |
Corresponding Author | Chan, Raymond C. K. |
Affiliation | 1.Cent China Normal Univ, Sch Psychol, Key Lab Adolescent Cyberpsychol & Behav CCNU, Minist Educ, Wuhan, Hubei, Peoples R China 2.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China 5.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, Sch Med, Shanghai, Peoples R China 6.MRI Ctr, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China 7.Castle Peak Hosp, Hong Kong, Peoples R China 8.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia 9.Griffith Univ, Sch Appl Psychol, Gold Coast, Australia |
First Author Affilication | 认知与发展心理学研究室 |
Corresponding Author Affilication | 认知与发展心理学研究室 |
Recommended Citation GB/T 7714 | Li, Xu,Yi, Zheng-hui,Lv, Qin-yu,et al. Clinical utility of the dual n-back task in schizophrenia: A functional imaging approach[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2019,284:37-44. |
APA | Li, Xu.,Yi, Zheng-hui.,Lv, Qin-yu.,Chu, Min-yi.,Hu, Hui-xin.,...&Chan, Raymond C. K..(2019).Clinical utility of the dual n-back task in schizophrenia: A functional imaging approach.PSYCHIATRY RESEARCH-NEUROIMAGING,284,37-44. |
MLA | Li, Xu,et al."Clinical utility of the dual n-back task in schizophrenia: A functional imaging approach".PSYCHIATRY RESEARCH-NEUROIMAGING 284(2019):37-44. |
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