Institutional Repository of Key Laboratory of Mental Health, CAS
Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake | |
Wang, Weiwen1,2; Wang, Li1,2; Xu, Hang1,2; Cao, Chengqi1,3; Liu, Ping4; Luo, Shu4; Duan, Qing1; Ellenbroek, Bart5; Zhang, Xiangyang1,2 | |
第一作者 | Weiwen Wang |
通讯作者邮箱 | wangli1@psych.ac.cn (l. wang) |
心理所单位排序 | 1 |
摘要 | Background: Many studies have shown that the disturbance of pro-inflammatory and/or anti-inflammatory cytokines is involved in the modulation of traumatic stress and related psychiatric disorders, typically posttraumatic stress disorder (PTSD). However, the specific immune alterations associated with PTSD symptoms are still unclear. The present study compared levels of pro-and anti-inflammatory cytokines between PTSD and non-PTSD controls, and investigated the relationships of immune changes with PTSD symptomatology. Methods: In this study, 51 earthquake-exposed PTSD patients and 136 earthquake-exposed healthy controls were recruited. We assessed trauma exposure, PTSD and depression severity, and quantified a panel of pro-inflammatory cytokines, including interleukin (IL)-1 beta, IL-2, IL-6, IL-8, tumor necrosis factor alpha (TNF-alpha), interferon gamma(IFN gamma), and anti-inflammatory cytokines, including IL-4, IL-10 and IL-13 with enzyme-linked immunosorbent assays. Additionally, total pro-inflammatory cytokines score and total anti-inflammatory cytokines score were calculated to reflect the status of two balance system. Results: Behavioral data showed that the PTSD group had greater severity of depression, as well as total symptoms and every symptom cluster in the seven-factor model of PTSD compared to the non-PTSD control group. Immune data showed that PTSD subjects had higher levels of IL-1 beta and TNF alpha, as well as total pro-inflammatory cytokine scores compared to controls, suggesting an increase of inflammatory activity in PTSD. In all subjects, the IL-1 beta levels were correlated with PCL scores, after controlling for covariates, including age, education, marital status and gender, trauma exposure severity and depression. Limitations: The current study did not include a non-traumatized healthy control group, and PTSD was assessed using a self-reported measure. Conclusions: Thus, by including a control group comprised entirely of earthquake-exposed individuals as means to discriminate specific alterations of cytokine levels in PTSD, these findings suggest that the increased inflammatory cytokines, especially IL-1 beta, may play a role in the pathophysiology of PTSD. |
关键词 | Earthquake Posttraumatic Stress Disorder Cytokines, Interleukin 1 Beta (Il-1 Beta) |
2019-04-01 | |
DOI | 10.1016/j.jad.2019.01.029 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS |
ISSN | 0165-0327 |
卷号 | 248页码:52-58 |
收录类别 | SCI ; SSCI |
资助项目 | National Natural Science Foundation of China[31771217] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; National Natural Science Foundation of China[81471122] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31271099] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Natural Science Foundation of China[31271099] ; National Natural Science Foundation of China[31471004] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; National Natural Science Foundation of China[81471122] ; External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; National Natural Science Foundation of China[31771217] |
出版者 | ELSEVIER SCIENCE BV |
WOS关键词 | Posttraumatic-stress-disorder ; Dimensional Structure ; Risk-factors ; Symptoms ; Inflammation ; Depression ; Cortisol ; Brain ; Interleukin-6 ; Immunity |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:000458696300008 |
WOS分区 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/28398 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Li |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Peoples R China 4.Peoples Hosp Deyang City, Deyang 618000, Sichuan, Peoples R China 5.Victoria Univ Wellington, Sch Psychol, Wellington 6012, New Zealand |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Wang, Weiwen,Wang, Li,Xu, Hang,et al. Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,248:52-58. |
APA | Wang, Weiwen.,Wang, Li.,Xu, Hang.,Cao, Chengqi.,Liu, Ping.,...&Zhang, Xiangyang.(2019).Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake.JOURNAL OF AFFECTIVE DISORDERS,248,52-58. |
MLA | Wang, Weiwen,et al."Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake".JOURNAL OF AFFECTIVE DISORDERS 248(2019):52-58. |
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