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Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake
Wang, Weiwen1,2; Wang, Li1,2; Xu, Hang1,2; Cao, Chengqi1,3; Liu, Ping4; Luo, Shu4; Duan, Qing1; Ellenbroek, Bart5; Zhang, Xiangyang1,2
First AuthorWeiwen Wang
2019-04-01
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
Correspondent Emailwangli1@psych.ac.cn (l. wang)
ISSN0165-0327
SubtypeArticle
Volume248Pages:52-58
Contribution Rank1
Abstract

Background: Many studies have shown that the disturbance of pro-inflammatory and/or anti-inflammatory cytokines is involved in the modulation of traumatic stress and related psychiatric disorders, typically posttraumatic stress disorder (PTSD). However, the specific immune alterations associated with PTSD symptoms are still unclear. The present study compared levels of pro-and anti-inflammatory cytokines between PTSD and non-PTSD controls, and investigated the relationships of immune changes with PTSD symptomatology. Methods: In this study, 51 earthquake-exposed PTSD patients and 136 earthquake-exposed healthy controls were recruited. We assessed trauma exposure, PTSD and depression severity, and quantified a panel of pro-inflammatory cytokines, including interleukin (IL)-1 beta, IL-2, IL-6, IL-8, tumor necrosis factor alpha (TNF-alpha), interferon gamma(IFN gamma), and anti-inflammatory cytokines, including IL-4, IL-10 and IL-13 with enzyme-linked immunosorbent assays. Additionally, total pro-inflammatory cytokines score and total anti-inflammatory cytokines score were calculated to reflect the status of two balance system. Results: Behavioral data showed that the PTSD group had greater severity of depression, as well as total symptoms and every symptom cluster in the seven-factor model of PTSD compared to the non-PTSD control group. Immune data showed that PTSD subjects had higher levels of IL-1 beta and TNF alpha, as well as total pro-inflammatory cytokine scores compared to controls, suggesting an increase of inflammatory activity in PTSD. In all subjects, the IL-1 beta levels were correlated with PCL scores, after controlling for covariates, including age, education, marital status and gender, trauma exposure severity and depression. Limitations: The current study did not include a non-traumatized healthy control group, and PTSD was assessed using a self-reported measure. Conclusions: Thus, by including a control group comprised entirely of earthquake-exposed individuals as means to discriminate specific alterations of cytokine levels in PTSD, these findings suggest that the increased inflammatory cytokines, especially IL-1 beta, may play a role in the pathophysiology of PTSD.

KeywordEarthquake Posttraumatic Stress Disorder Cytokines, Interleukin 1 Beta (Il-1 Beta)
DOI10.1016/j.jad.2019.01.029
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31771217] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; National Natural Science Foundation of China[81471122] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31271099] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS Key Laboratory of Mental Health, Institute of Psychology ; National Natural Science Foundation of China[31271099] ; National Natural Science Foundation of China[31471004] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; National Natural Science Foundation of China[81471122] ; External Cooperation Program of Chinese Academy of Sciences[153111KYSB20160036] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; National Natural Science Foundation of China[31771217]
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000458696300008
PublisherELSEVIER SCIENCE BV
WOS KeywordPosttraumatic-stress-disorder ; Dimensional Structure ; Risk-factors ; Symptoms ; Inflammation ; Depression ; Cortisol ; Brain ; Interleukin-6 ; Immunity
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28398
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Li
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Peoples R China
4.Peoples Hosp Deyang City, Deyang 618000, Sichuan, Peoples R China
5.Victoria Univ Wellington, Sch Psychol, Wellington 6012, New Zealand
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Weiwen,Wang, Li,Xu, Hang,et al. Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,248:52-58.
APA Wang, Weiwen.,Wang, Li.,Xu, Hang.,Cao, Chengqi.,Liu, Ping.,...&Zhang, Xiangyang.(2019).Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake.JOURNAL OF AFFECTIVE DISORDERS,248,52-58.
MLA Wang, Weiwen,et al."Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake".JOURNAL OF AFFECTIVE DISORDERS 248(2019):52-58.
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