Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m | |
Xu, Mengbo1; Xiang, Yuanhang1,2; Liu, Xiaojun3,4; Bai, Baoyan5; Chen, Runsheng5; Liu, Li1,2,6; Li, Meixia1,2 | |
第一作者 | Mengbo Xu |
通讯作者邮箱 | li liu liuli@sun5.ibp.ac.cn ; meixia li limeixia@ibp.ac.cn |
心理所单位排序 | 1 |
摘要 | It is obvious that the majority of cellular transcripts are long noncoding RNAs (lncRNAs). Although studies suggested that lncRNAs participate in many biological processes through diverse mechanisms, however, little is known about their effects on epidermal mechanoreceptors. Here, we identified one novel Drosophila lncRNA, Scutellar Macrochaetes Regulatory Gene (SMRG), which regulates scutellar macrochaetes that act as mechanoreceptors by antagonizing the proneural gene scute (sc), through the repressor Enhancer-of-split m (E(spl)m). SMRG deficiency induced supernumerary scutellar macrochaetes and simultaneously a high sc RNA level in the adult thorax. Genetically, sc overexpression enhanced this supernumerary phenotype, while heterozygous sc mutant rescued this phenotype, both of which were mediated by E(spl)m. At the molecular level, SMRG recruited E(spl)m to the sc promoter region, which in turn suppressed sc expression. Our work presents a novel function of lncRNA and offers insights into the molecular mechanism underlying mechanoreceptor development. |
关键词 | Mechanoreceptor development long noncoding RNA Drosophila |
2019-01-02 | |
语种 | 英语 |
DOI | 10.1080/15476286.2018.1556148 |
发表期刊 | RNA BIOLOGY |
ISSN | 1547-6286 |
卷号 | 16期号:1页码:42-53 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | Key Research Program of Frontier Sciences, CAS[QYZDY-SSW-SMC015] ; National Natural Sciences Foundation of China[91632107] ; National Natural Sciences Foundation of China[31571033] |
出版者 | TAYLOR & FRANCIS INC |
WOS关键词 | PRONEURAL CLUSTERS ; GENE-COMPLEX ; ACHAETE ; EXPRESSION ; TRANSCRIPTION ; CHROMATIN ; PROTEINS ; PATTERN ; SYSTEM ; NOTCH |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemistry & Molecular Biology |
WOS记录号 | WOS:000459050300005 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/28401 |
专题 | 脑与认知科学国家重点实验室 |
通讯作者 | Liu, Li; Li, Meixia |
作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 3.Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China 4.Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Biophys, Key Lab Noncoding RNA, Beijing, Peoples R China 6.Chinese Acad Sci, Key Lab Mental Hlth, Beijing, Peoples R China |
第一作者单位 | 脑与认知科学国家重点实验室 |
通讯作者单位 | 脑与认知科学国家重点实验室; 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Xu, Mengbo,Xiang, Yuanhang,Liu, Xiaojun,et al. Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m[J]. RNA BIOLOGY,2019,16(1):42-53. |
APA | Xu, Mengbo.,Xiang, Yuanhang.,Liu, Xiaojun.,Bai, Baoyan.,Chen, Runsheng.,...&Li, Meixia.(2019).Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m.RNA BIOLOGY,16(1),42-53. |
MLA | Xu, Mengbo,et al."Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m".RNA BIOLOGY 16.1(2019):42-53. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Long noncoding RNA S(3492KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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