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Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m
Xu, Mengbo1; Xiang, Yuanhang1,2; Liu, Xiaojun3,4; Bai, Baoyan5; Chen, Runsheng5; Liu, Li1,2,6; Li, Meixia1,2
First AuthorMengbo Xu
2019-01-02
Source PublicationRNA BIOLOGY
Correspondent Emailli liu liuli@sun5.ibp.ac.cn ; meixia li limeixia@ibp.ac.cn
ISSN1547-6286
Subtypearticle
Volume16Issue:1Pages:42-53
Contribution Rank1
Abstract

It is obvious that the majority of cellular transcripts are long noncoding RNAs (lncRNAs). Although studies suggested that lncRNAs participate in many biological processes through diverse mechanisms, however, little is known about their effects on epidermal mechanoreceptors. Here, we identified one novel Drosophila lncRNA, Scutellar Macrochaetes Regulatory Gene (SMRG), which regulates scutellar macrochaetes that act as mechanoreceptors by antagonizing the proneural gene scute (sc), through the repressor Enhancer-of-split m (E(spl)m). SMRG deficiency induced supernumerary scutellar macrochaetes and simultaneously a high sc RNA level in the adult thorax. Genetically, sc overexpression enhanced this supernumerary phenotype, while heterozygous sc mutant rescued this phenotype, both of which were mediated by E(spl)m. At the molecular level, SMRG recruited E(spl)m to the sc promoter region, which in turn suppressed sc expression. Our work presents a novel function of lncRNA and offers insights into the molecular mechanism underlying mechanoreceptor development.

KeywordMechanoreceptor development long noncoding RNA Drosophila
DOI10.1080/15476286.2018.1556148
Indexed BySCI
Language英语
Funding ProjectKey Research Program of Frontier Sciences, CAS[QYZDY-SSW-SMC015] ; National Natural Sciences Foundation of China[91632107] ; National Natural Sciences Foundation of China[31571033]
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000459050300005
PublisherTAYLOR & FRANCIS INC
WOS KeywordPRONEURAL CLUSTERS ; GENE-COMPLEX ; ACHAETE ; EXPRESSION ; TRANSCRIPTION ; CHROMATIN ; PROTEINS ; PATTERN ; SYSTEM ; NOTCH
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28401
Collection脑与认知科学国家重点实验室
Corresponding AuthorLiu, Li; Li, Meixia
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
3.Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
4.Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Biophys, Key Lab Noncoding RNA, Beijing, Peoples R China
6.Chinese Acad Sci, Key Lab Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Xu, Mengbo,Xiang, Yuanhang,Liu, Xiaojun,et al. Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m[J]. RNA BIOLOGY,2019,16(1):42-53.
APA Xu, Mengbo.,Xiang, Yuanhang.,Liu, Xiaojun.,Bai, Baoyan.,Chen, Runsheng.,...&Li, Meixia.(2019).Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m.RNA BIOLOGY,16(1),42-53.
MLA Xu, Mengbo,et al."Long noncoding RNA SMRG regulates Drosophila macrochaetes by antagonizing scute through E(spl)m".RNA BIOLOGY 16.1(2019):42-53.
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