Institutional Repository of Key Laboratory of Mental Health, CAS
Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder | |
Wang, Yong-ming1,2,3,4; Zou, Lai-quan1,5; Xie, Wen-lan1,4; Yang, Zhuo-ya1,4; Zhu, Xiong-zhao6,7; Cheung, Eric F. C.8; Sorensen, Thomas Alrik3,9; Moller, Arne3,10,11; Chan, Raymond C. K.1,2,3,4 | |
第一作者 | Yong-ming Wang |
通讯作者邮箱 | rckchan@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders. |
关键词 | schizo-obsessive comorbidity schizo phrenia obsessive-compulsive disorder functional connectivity default mode network |
2019 | |
语种 | 英语 |
DOI | 10.1093/schbul/sbx194 |
发表期刊 | SCHIZOPHRENIA BULLETIN |
ISSN | 0586-7614 |
卷号 | 45期号:1页码:199-210 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | CAS Key Laboratory of Mental Health ; Chinese Academy of Science[XDB02030002] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; National Key Research and Development Programme[2016YFC0906402] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] |
出版者 | OXFORD UNIV PRESS |
WOS关键词 | POSTTRAUMATIC-STRESS-DISORDER ; RESTING-STATE ; VULNERABILITY MARKER ; SALIENCE NETWORK ; SYMPTOMS ; PSYCHOSIS ; NEUROPSYCHOLOGY ; SYMPTOMATOLOGY ; RELEVANCE ; THALAMUS |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000461523000025 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/28600 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China 3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Southern Med Univ, Dept Psychol, Sch Publ Hlth, Guangdong Prov Key Lab Trop Dis Res, Guangzhou, Guangdong, Peoples R China 6.Cent S Univ, Med Psychol Ctr, Xiangya Hosp 2, Changsha, Hunan, Peoples R China 7.Cent S Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China 8.Castle Peak Hosp, Hong Kong, Peoples R China 9.Aalborg Univ, Inst Commun & Psychol, Ctr Cognit Neurosci, Aalborg, Denmark 10.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark 11.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark |
第一作者单位 | 认知与发展心理学研究室 |
通讯作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Wang, Yong-ming,Zou, Lai-quan,Xie, Wen-lan,et al. Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder[J]. SCHIZOPHRENIA BULLETIN,2019,45(1):199-210. |
APA | Wang, Yong-ming.,Zou, Lai-quan.,Xie, Wen-lan.,Yang, Zhuo-ya.,Zhu, Xiong-zhao.,...&Chan, Raymond C. K..(2019).Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder.SCHIZOPHRENIA BULLETIN,45(1),199-210. |
MLA | Wang, Yong-ming,et al."Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder".SCHIZOPHRENIA BULLETIN 45.1(2019):199-210. |
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Altered Functional C(436KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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