PSYCH OpenIR  > 中国科学院心理健康重点实验室
Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder
Wang, Yong-ming1,2,3,4; Zou, Lai-quan1,5; Xie, Wen-lan1,4; Yang, Zhuo-ya1,4; Zhu, Xiong-zhao6,7; Cheung, Eric F. C.8; Sorensen, Thomas Alrik3,9; Moller, Arne3,10,11; Chan, Raymond C. K.1,2,3,4
First AuthorYong-ming Wang
2019
Source PublicationSCHIZOPHRENIA BULLETIN
Correspondent Emailrckchan@psych.ac.cn
ISSN0586-7614
SubtypeArticle
Volume45Issue:1Pages:199-210
Contribution Rank1
Abstract

Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders.

Keywordschizo-obsessive comorbidity schizo phrenia obsessive-compulsive disorder functional connectivity default mode network
DOI10.1093/schbul/sbx194
Indexed BySCI
Language英语
Funding ProjectCAS Key Laboratory of Mental Health ; Chinese Academy of Science[XDB02030002] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; National Key Research and Development Programme[2016YFC0906402] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000461523000025
PublisherOXFORD UNIV PRESS
WOS KeywordPOSTTRAUMATIC-STRESS-DISORDER ; RESTING-STATE ; VULNERABILITY MARKER ; SALIENCE NETWORK ; SYMPTOMS ; PSYCHOSIS ; NEUROPSYCHOLOGY ; SYMPTOMATOLOGY ; RELEVANCE ; THALAMUS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28600
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Southern Med Univ, Dept Psychol, Sch Publ Hlth, Guangdong Prov Key Lab Trop Dis Res, Guangzhou, Guangdong, Peoples R China
6.Cent S Univ, Med Psychol Ctr, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
7.Cent S Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China
8.Castle Peak Hosp, Hong Kong, Peoples R China
9.Aalborg Univ, Inst Commun & Psychol, Ctr Cognit Neurosci, Aalborg, Denmark
10.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark
11.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
Recommended Citation
GB/T 7714
Wang, Yong-ming,Zou, Lai-quan,Xie, Wen-lan,et al. Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder[J]. SCHIZOPHRENIA BULLETIN,2019,45(1):199-210.
APA Wang, Yong-ming.,Zou, Lai-quan.,Xie, Wen-lan.,Yang, Zhuo-ya.,Zhu, Xiong-zhao.,...&Chan, Raymond C. K..(2019).Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder.SCHIZOPHRENIA BULLETIN,45(1),199-210.
MLA Wang, Yong-ming,et al."Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder".SCHIZOPHRENIA BULLETIN 45.1(2019):199-210.
Files in This Item:
File Name/Size DocType Version Access License
Altered Functional C(436KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Yong-ming]'s Articles
[Zou, Lai-quan]'s Articles
[Xie, Wen-lan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Yong-ming]'s Articles
[Zou, Lai-quan]'s Articles
[Xie, Wen-lan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Yong-ming]'s Articles
[Zou, Lai-quan]'s Articles
[Xie, Wen-lan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity_ A Comparison Between Schizophrenia and Obsessive-compulsive Disorder.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.