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The top-down regulation from the prefrontal cortex to insula via hypnotic aversion suggestions reduces smoking craving | |
Li, Xiaoming1,2,3; Chen, Lijun2,3,4,5; Ma, Ru2,3; Wang, Haibao6; Wan, Li2,3; Wang, Ying2,3; Bu, Junjie2,3; Hong, Wei2,3; Lv, Wanwan2,3; Volistaedt-Klein, Sabine7; Yang, Yihong8; Zhang, Xiaochu2,3,9,10,11 | |
第一作者 | Xiaoming Li |
通讯作者邮箱 | zxcustc@ustc.edu.cn |
心理所单位排序 | 3 |
摘要 | Hypnosis has been shown to have treatment effects on nicotine addiction. However, the neural basis of these effects is poorly understood. This preliminary study investigated the neural mechanisms of hypnosis-based treatment on cigarette smoking, specifically, whether the hypnosis involves a top-down or bottom-up mechanism. Two groups of 45 smokers underwent a smoking aversion suggestion and viewed smoking-related pictures and neutral pictures. One group underwent functional magnetic resonance imaging scanning twice (control and hypnotic states), whereas the other group underwent two electroencephalograph sessions. Our study found that self-reported smoking craving decreased in both groups following hypnosis. Smoking cue-elicited activations in the right dorsal lateral prefrontal cortex (rDLPFC) and left insula (lI) and the functional connectivity between the rDLPFC and lI were increased in the hypnotic state compared with the control state. The delta band source waveforms indicated the activation from 390 to 862 ms at the rDLPFC and from 490 to 900 ms at the lI was significantly different between the smoking and neutral conditions in the hypnotic state, suggesting the activation in the rDLPFC preceded that in the lI. These results suggest that the decreased smoking craving via hypnotic aversion suggestions may arise from the top-down regulation of the rDLPFC to the lI. Our findings provide novel neurobiological evidence for understanding the therapeutic effects of hypnosis on nicotine addiction, and the prefrontal-insula circuit may serve as an imaging biomarker to monitor the treatment efficacy noninvasively. |
关键词 | EEG fMRI hypnosis nicotine addiction smoking craving |
2019-04-15 | |
语种 | 英语 |
DOI | 10.1002/hbm.24483 |
发表期刊 | HUMAN BRAIN MAPPING |
ISSN | 1065-9471 |
卷号 | 40期号:6页码:1718-1728 |
期刊论文类型 | whblqh@mail.ustc.edu.cn |
收录类别 | SCI |
资助项目 | project of human social science of Anhui province[SK2016A047] ; University of Science and Technology of China ; National Natural Science Foundation of China[81171326] ; National Natural Science Foundation of China[31471071] ; National Natural Science Foundation of China[31771221] ; National Natural Science Foundation of China[31171083] ; Anhui Natural Science Foundation[1808085MH291] ; Open Foundation of CAS Key Laboratory of Brain Function and Disease of University of Science and Technology of China[2013-3] |
出版者 | WILEY |
WOS关键词 | UNDERSTANDING HYPNOSIS ; CUE-REACTIVITY ; NICOTINE ; CESSATION ; ANXIETY ; ADOLESCENTS ; INHIBITION ; DEPENDENCE ; ATTENTION ; ADDICTION |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000460987100003 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/28622 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Haibao; Zhang, Xiaochu |
作者单位 | 1.Anhui Med Univ, Chaohu Clin Med Coll, Dept Med Psychol, Hefei, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei, Anhui, Peoples R China 7.Heidelberg Univ, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, Mannheim, Germany 8.NIDA, Neuroimaging Res Branch, Intramural Res Program, NIH, Baltimore, MD USA 9.Tianjin Normal Univ, Acad Psychol & Behav, Tianjin, Peoples R China 10.Univ Sci & Technol China, Ctr Biomed Engn, Hefei, Anhui, Peoples R China 11.Anhui Mental Hlth Ctr, Anhui Mental Res Ctr Alcohol Addict, Hefei, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Xiaoming,Chen, Lijun,Ma, Ru,et al. The top-down regulation from the prefrontal cortex to insula via hypnotic aversion suggestions reduces smoking craving[J]. HUMAN BRAIN MAPPING,2019,40(6):1718-1728. |
APA | Li, Xiaoming.,Chen, Lijun.,Ma, Ru.,Wang, Haibao.,Wan, Li.,...&Zhang, Xiaochu.(2019).The top-down regulation from the prefrontal cortex to insula via hypnotic aversion suggestions reduces smoking craving.HUMAN BRAIN MAPPING,40(6),1718-1728. |
MLA | Li, Xiaoming,et al."The top-down regulation from the prefrontal cortex to insula via hypnotic aversion suggestions reduces smoking craving".HUMAN BRAIN MAPPING 40.6(2019):1718-1728. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
The top-down regulat(1699KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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