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The top-down regulation from the prefrontal cortex to insula via hypnotic aversion suggestions reduces smoking craving
Li, Xiaoming1,2,3; Chen, Lijun2,3,4,5; Ma, Ru2,3; Wang, Haibao6; Wan, Li2,3; Wang, Ying2,3; Bu, Junjie2,3; Hong, Wei2,3; Lv, Wanwan2,3; Volistaedt-Klein, Sabine7; Yang, Yihong8; Zhang, Xiaochu2,3,9,10,11
First AuthorXiaoming Li
2019-04-15
Source PublicationHUMAN BRAIN MAPPING
Correspondent Emailzxcustc@ustc.edu.cn
ISSN1065-9471
Subtypewhblqh@mail.ustc.edu.cn
Volume40Issue:6Pages:1718-1728
Contribution Rank3
Abstract

Hypnosis has been shown to have treatment effects on nicotine addiction. However, the neural basis of these effects is poorly understood. This preliminary study investigated the neural mechanisms of hypnosis-based treatment on cigarette smoking, specifically, whether the hypnosis involves a top-down or bottom-up mechanism. Two groups of 45 smokers underwent a smoking aversion suggestion and viewed smoking-related pictures and neutral pictures. One group underwent functional magnetic resonance imaging scanning twice (control and hypnotic states), whereas the other group underwent two electroencephalograph sessions. Our study found that self-reported smoking craving decreased in both groups following hypnosis. Smoking cue-elicited activations in the right dorsal lateral prefrontal cortex (rDLPFC) and left insula (lI) and the functional connectivity between the rDLPFC and lI were increased in the hypnotic state compared with the control state. The delta band source waveforms indicated the activation from 390 to 862 ms at the rDLPFC and from 490 to 900 ms at the lI was significantly different between the smoking and neutral conditions in the hypnotic state, suggesting the activation in the rDLPFC preceded that in the lI. These results suggest that the decreased smoking craving via hypnotic aversion suggestions may arise from the top-down regulation of the rDLPFC to the lI. Our findings provide novel neurobiological evidence for understanding the therapeutic effects of hypnosis on nicotine addiction, and the prefrontal-insula circuit may serve as an imaging biomarker to monitor the treatment efficacy noninvasively.

KeywordEEG fMRI hypnosis nicotine addiction smoking craving
DOI10.1002/hbm.24483
Indexed BySCI
Language英语
Funding Projectproject of human social science of Anhui province[SK2016A047] ; University of Science and Technology of China ; National Natural Science Foundation of China[81171326] ; National Natural Science Foundation of China[31471071] ; National Natural Science Foundation of China[31771221] ; National Natural Science Foundation of China[31171083] ; Anhui Natural Science Foundation[1808085MH291] ; Open Foundation of CAS Key Laboratory of Brain Function and Disease of University of Science and Technology of China[2013-3]
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000460987100003
PublisherWILEY
WOS KeywordUNDERSTANDING HYPNOSIS ; CUE-REACTIVITY ; NICOTINE ; CESSATION ; ANXIETY ; ADOLESCENTS ; INHIBITION ; DEPENDENCE ; ATTENTION ; ADDICTION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28622
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Haibao; Zhang, Xiaochu
Affiliation1.Anhui Med Univ, Chaohu Clin Med Coll, Dept Med Psychol, Hefei, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei, Anhui, Peoples R China
7.Heidelberg Univ, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, Mannheim, Germany
8.NIDA, Neuroimaging Res Branch, Intramural Res Program, NIH, Baltimore, MD USA
9.Tianjin Normal Univ, Acad Psychol & Behav, Tianjin, Peoples R China
10.Univ Sci & Technol China, Ctr Biomed Engn, Hefei, Anhui, Peoples R China
11.Anhui Mental Hlth Ctr, Anhui Mental Res Ctr Alcohol Addict, Hefei, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiaoming,Chen, Lijun,Ma, Ru,et al. The top-down regulation from the prefrontal cortex to insula via hypnotic aversion suggestions reduces smoking craving[J]. HUMAN BRAIN MAPPING,2019,40(6):1718-1728.
APA Li, Xiaoming.,Chen, Lijun.,Ma, Ru.,Wang, Haibao.,Wan, Li.,...&Zhang, Xiaochu.(2019).The top-down regulation from the prefrontal cortex to insula via hypnotic aversion suggestions reduces smoking craving.HUMAN BRAIN MAPPING,40(6),1718-1728.
MLA Li, Xiaoming,et al."The top-down regulation from the prefrontal cortex to insula via hypnotic aversion suggestions reduces smoking craving".HUMAN BRAIN MAPPING 40.6(2019):1718-1728.
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