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Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study
Yan, Xiaohe2,3; Wang, Yun4,5,6,7; Xu, Lijuan8,9; Liu, Yong8,9; Song, Shaojie1; Ding, Kun1; Zhou, Yuan7; Jiang, Tianzi8,9; Lin, Xiaoming1
First AuthorXiaohe Yan M.D., Ph.D
2019-03-04
Source PublicationCURRENT EYE RESEARCH
Correspondent Emailxiaoming lin(linxiaom@hotmail.com) ; jiang, tianzi(jiangtz@nlpr.ia.ac.cn)
ISSN0271-3683
Subtypearticle
Volume44Issue:3Pages:316-323
Contribution Rank7
Abstract

Purpose: The aim of this study was to examine the functional connectivity between the primary visual cortex and other cortical areas during rest in normal subjects and patients with comitant strabismus using functional magnetic resonance imaging (fMRI). Methods: A prospective, observational study was conducted. Ten patients with comitant exotropia and eleven matched healthy subjects underwent resting-state fMRI with their eyes closed. Resting-state fMRI was performed using a 3.0 T MR scanner. The primary visual cortex was subdivided into anterior and posterior subdivisions. The resting-state functional connectivities within the primary visual cortex and between the primary visual cortex and other cortical areas were calculated for each group and compared between the strabismic and normal control groups. fMRI data were analyzed using Statistical Parametric Mapping software and Analysis of Functional NeuroImages software. Results: Compared with the normal controls, patients with comitant strabismus had increased functional connectivity between the posterior primary visual cortex and other cortical areas, especially the visual cortex [Brodmann area 19 (BA19)] and other oculomotor regions, such as the frontal eye field (BA6). Conclusions: The fMRI results suggest that ongoing and permanent cortical changes occur in patients with comitant strabismus. Disrupted brain functional connectivities are associated with abnormal eye movement and loss of stereopsis. Our study provides a neurological basis for understanding the pathophysiology of comitant strabismus, which may prompt new areas of research to more precisely define this basis and extend these findings to enhance diagnosis and treatment.

KeywordFunctional connectivity primary visual cortex comitant strabismus resting-state functional magnetic resonance imaging (fMRI)
DOI10.1080/02713683.2018.1540642
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81500708] ; Natural Science Foundation of Guangdong[2014A030310084] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2016A020216002] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2015A020212002] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2013B020307004] ; Research Foundation of Science and Technology Plan Project, Guangdong, China[2012B061700084] ; Research Foundation of Science and Technology Plan Project, Shenzhen, China[JCYJ20170413143051465] ; Research Foundation of Science and Technology Plan Project, Shenzhen, China[JCYJ20150730150557658]
WOS Research AreaOphthalmology
WOS SubjectOphthalmology
WOS IDWOS:000460060500011
PublisherTAYLOR & FRANCIS INC
WOS KeywordEYES OPEN ; HUMAN BRAIN ; PARCELLATION ; SUPPRESSION ; SEGREGATION ; TOPOGRAPHY ; PLASTICITY ; AMBLYOPIA ; EXOTROPIA ; ESOTROPIA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28631
Collection社会与工程心理学研究室
Corresponding AuthorJiang, Tianzi; Lin, Xiaoming
Affiliation1.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China
2.Jinan Univ, Shenzhen Eye Hosp, Shenzhen Key Lab Ophthalmol, Shenzhen, Peoples R China
3.Shenzhen Univ, Sch Optometry, Shenzhen, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
5.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
6.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci & Magnet Resonance Imaging Res, Beijing, Peoples R China
8.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yan, Xiaohe,Wang, Yun,Xu, Lijuan,et al. Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study[J]. CURRENT EYE RESEARCH,2019,44(3):316-323.
APA Yan, Xiaohe.,Wang, Yun.,Xu, Lijuan.,Liu, Yong.,Song, Shaojie.,...&Lin, Xiaoming.(2019).Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study.CURRENT EYE RESEARCH,44(3),316-323.
MLA Yan, Xiaohe,et al."Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study".CURRENT EYE RESEARCH 44.3(2019):316-323.
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