Institutional Repository of Key Laboratory of Behavioral Science, CAS
| Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands | |
Chang, Miao1,3; Edmiston, Elliot K.3; Womer, Fay Y.4; Thou, Qian2,3; Wei, Shengnan1,3; Jiang, Maowei1,3; Zhou, Yifang2,3; Ye, Yuting5; Huang, Haiyan5; Zuo, Xi-Nian6,7 ; Xu, Ke1,3; Tang, Yanqing2,3; Wang, Fei1,3
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| Corresponding Author | Tang, Yanqing(yanqingtang@163.com) ; Wang, Fei(fei.wang@cmu.edu.cn) |
| 2019-03-01 | |
| Source Publication | JOURNAL OF PSYCHIATRY & NEUROSCIENCE
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| ISSN | 1180-4882 |
| Volume | 44Issue:2Pages:132-141 |
| Abstract | Background Growing evidence indicates both shared and distinct features of emotional perception in schizophrenia, bipolar disorder and major depressive disorder. In these disorders, alterations in spontaneous low-frequency fluctuations have been reported in the neural system for emotional perception, but the similarities and differences in the amplitude of low-frequency fluctuation (ALFF) across the 3 disorders are unknown. Methods We compared ALFF and its signal balance in the neural system for emotional perception at 2 frequency bands (slow-5 and slow-4) in 119 participants with schizophrenia, 100 with bipolar disorder, 123 with major depressive disorder and 183 healthy controls. We performed exploratory Pearson partial correlation analyses to determine the relationship between ALFF signal balance and clinical variables. Results We observed commonalities in ALFF change patterns across the 3 disorders for emotional perception neural substrates, such as increased ALFF in the anterior cerebrum (including subcortical, limbic, paralimbic and heteromodal cortical regions) and decreased ALFF in the posterior visual cortices. Schizophrenia, bipolar disorder and major depressive disorder showed significantly decreased ALFF signal balance in the neural system for emotional perception at both slow-5 and slow-4 frequency bands, with the greatest alterations for schizophrenia, followed by bipolar disorder and major depressive disorder. We found a negative correlation between ALFF signal balance and negative/disorganized symptoms in slow-4 across the 3 disorders. Limitations The relatively broad age range in our sample and the cross-sectional study design may not account for our findings. Conclusion The extent of the commonalities we observed further support the concept of core neurobiological disruptions shared among the 3 disorders; ALFF signal balance could be an important neuroimaging marker for the diagnosis and treatment of schizophrenia, bipolar disorder and major depressive disorder. |
| DOI | 10.1503/jpn.170226 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Organization | National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; National Key Research and Development Program ; Liaoning Education Foundation ; National High Tech Development Plan (863) ; Shenyang Mental Health Centre, Department of Psychiatry and Radiology, First Affiliated Hospital of China Medical University |
| Funding Project | National Natural Science Foundation of China[81571311] ; National Natural Science Foundation of China[81071099] ; National Natural Science Foundation of China[81271499] ; National Natural Science Foundation of China[81725005] ; National Natural Science Foundation of China[81571331] ; National Science Fund for Distinguished Young Scholars[81725005] ; National Key Research and Development Program[2016YFC0904300] ; National Key Research and Development Program[2016YFC1306900] ; Liaoning Education Foundation ; National High Tech Development Plan (863)[2015AA020513] ; Shenyang Mental Health Centre, Department of Psychiatry and Radiology, First Affiliated Hospital of China Medical University |
| WOS Research Area | Neurosciences & Neurology ; Psychiatry |
| WOS Subject | Neurosciences ; Psychiatry |
| WOS ID | WOS:000460188300007 |
| Publisher | CMA-CANADIAN MEDICAL ASSOC |
| WOS Keyword | RESTING-STATE FMRI ; DEPRESSIVE DISORDER ; BIPOLAR DISORDER ; BRAIN ACTIVITY ; VISUAL-CORTEX ; SCHIZOPHRENIA ; IDENTIFICATION ; METAANALYSIS ; SPECIFICITY ; ACTIVATION |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/28646 |
| Collection | 中国科学院行为科学重点实验室 |
| Corresponding Author | Tang, Yanqing; Wang, Fei |
| Affiliation | 1.China Med Univ, Affiliated Hosp 1, Dept Radiol, Shenyang, Liaoning, Peoples R China 2.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China 3.China Med Univ, Affiliated Hosp 1, Brain Funct Res Sect, Shenyang, Liaoning, Peoples R China 4.Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA 5.Univ Calif Berkeley, Div Biostat, Berkeley, CA 94720 USA 6.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Chang, Miao,Edmiston, Elliot K.,Womer, Fay Y.,et al. Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2019,44(2):132-141. |
| APA | Chang, Miao.,Edmiston, Elliot K..,Womer, Fay Y..,Thou, Qian.,Wei, Shengnan.,...&Wang, Fei.(2019).Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,44(2),132-141. |
| MLA | Chang, Miao,et al."Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 44.2(2019):132-141. |
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