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Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands
Chang, Miao1,3; Edmiston, Elliot K.3; Womer, Fay Y.4; Thou, Qian2,3; Wei, Shengnan1,3; Jiang, Maowei1,3; Zhou, Yifang2,3; Ye, Yuting5; Huang, Haiyan5; Zuo, Xi-Nian6,7; Xu, Ke1,3; Tang, Yanqing2,3; Wang, Fei1,3
First AuthorMiao Chang
2019-03-01
Source PublicationJOURNAL OF PSYCHIATRY & NEUROSCIENCE
Correspondent Emailfei.wang@cmu.edu.cn ; yanqingtang@ 163.com
ISSN1180-4882
SubtypeArticle
Volume44Issue:2Pages:132-141
Contribution Rank6
Abstract

Background Growing evidence indicates both shared and distinct features of emotional perception in schizophrenia, bipolar disorder and major depressive disorder. In these disorders, alterations in spontaneous low-frequency fluctuations have been reported in the neural system for emotional perception, but the similarities and differences in the amplitude of low-frequency fluctuation (ALFF) across the 3 disorders are unknown. Methods We compared ALFF and its signal balance in the neural system for emotional perception at 2 frequency bands (slow-5 and slow-4) in 119 participants with schizophrenia, 100 with bipolar disorder, 123 with major depressive disorder and 183 healthy controls. We performed exploratory Pearson partial correlation analyses to determine the relationship between ALFF signal balance and clinical variables. Results We observed commonalities in ALFF change patterns across the 3 disorders for emotional perception neural substrates, such as increased ALFF in the anterior cerebrum (including subcortical, limbic, paralimbic and heteromodal cortical regions) and decreased ALFF in the posterior visual cortices. Schizophrenia, bipolar disorder and major depressive disorder showed significantly decreased ALFF signal balance in the neural system for emotional perception at both slow-5 and slow-4 frequency bands, with the greatest alterations for schizophrenia, followed by bipolar disorder and major depressive disorder. We found a negative correlation between ALFF signal balance and negative/disorganized symptoms in slow-4 across the 3 disorders. Limitations The relatively broad age range in our sample and the cross-sectional study design may not account for our findings. Conclusion The extent of the commonalities we observed further support the concept of core neurobiological disruptions shared among the 3 disorders; ALFF signal balance could be an important neuroimaging marker for the diagnosis and treatment of schizophrenia, bipolar disorder and major depressive disorder.

DOI10.1503/jpn.170226
Indexed BySCI
Language英语
Funding ProjectShenyang Mental Health Centre, Department of Psychiatry and Radiology, First Affiliated Hospital of China Medical University ; National High Tech Development Plan (863)[2015AA020513] ; Liaoning Education Foundation ; National Key Research and Development Program[2016YFC1306900] ; National Key Research and Development Program[2016YFC0904300] ; National Science Fund for Distinguished Young Scholars[81725005] ; National Natural Science Foundation of China[81571331] ; National Natural Science Foundation of China[81725005] ; National Natural Science Foundation of China[81271499] ; National Natural Science Foundation of China[81071099] ; National Natural Science Foundation of China[81571311]
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectNeurosciences ; Psychiatry
WOS IDWOS:000460188300007
PublisherCMA-CANADIAN MEDICAL ASSOC
WOS KeywordRESTING-STATE FMRI ; DEPRESSIVE DISORDER ; BIPOLAR DISORDER ; BRAIN ACTIVITY ; VISUAL-CORTEX ; SCHIZOPHRENIA ; IDENTIFICATION ; METAANALYSIS ; SPECIFICITY ; ACTIVATION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28646
Collection中国科学院行为科学重点实验室
Corresponding AuthorTang, Yanqing; Wang, Fei
Affiliation1.China Med Univ, Affiliated Hosp 1, Dept Radiol, Shenyang, Liaoning, Peoples R China
2.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China
3.China Med Univ, Affiliated Hosp 1, Brain Funct Res Sect, Shenyang, Liaoning, Peoples R China
4.Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
5.Univ Calif Berkeley, Div Biostat, Berkeley, CA 94720 USA
6.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Chang, Miao,Edmiston, Elliot K.,Womer, Fay Y.,et al. Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2019,44(2):132-141.
APA Chang, Miao.,Edmiston, Elliot K..,Womer, Fay Y..,Thou, Qian.,Wei, Shengnan.,...&Wang, Fei.(2019).Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,44(2),132-141.
MLA Chang, Miao,et al."Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 44.2(2019):132-141.
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