| Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia | |
| Yang, Fang1; Wang, Keming2; Du, Xiangdong3; Deng, Huiqiong1; Wu, Hanjing Emily1; Yin, Guangzhong3; Ning, Yuping4; Huang, Xingbing4; Teixeira, Antonio L.1; de Quevedo, Joao1; Soares, Jair C.1; Li, Xiaosi2; Lang, XiaoE5; Zhang, Xiang Yang1,6 | |
| Corresponding Author | Lang, XiaoE(langxiaoe@yeah.net) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 2019-02-01 | |
| Source Publication | PSYCHOPHARMACOLOGY
 |
| ISSN | 0033-3158 |
| Volume | 236Issue:2Pages:753-762 |
| Abstract | Rationale and objectiveSchizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex differences in the relationship between serum BDNF levels and obesity in patients with chronic schizophrenia.MethodsWe recruited 132 Chinese patients with chronic schizophrenia (98 males and 34 females) and compared sex differences in the body mass index (BMI), obesity, serum BDNF levels, and their associations. Psychopathology symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). A regression model with various demographic and clinical variables was applied to predict the serum levels of BDNF.ResultsFemale patients had a higher rate of obesity and higher BMI, but lower BDNF levels than male schizophreniapatients. A significantly negative correlation was observed between BMI and BDNF levels only in female patients but not in male patients. The multiple regression model with demographic and clinical variables significantly predicted BDNF levels only in female patients, with a medium size effect. And only in female patients, BMI made a significant contribution to this prediction.ConclusionOur results indicate significant sex differences in the obesity, BMI, BDNF levels, and their association in chronic patients with schizophrenia, showing a significant inverse correlation between BMI and BDNF levels only in female patients. Thus, sex needs to be considered when assessing the relationship between BDNF and metabolic syndromes in schizophrenia. |
| Keyword | Schizophrenia Sex difference Brain-derived neurotrophic factor Obesity Body mass index |
| DOI | 10.1007/s00213-018-5107-1 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Organization | National Natural Science Foundation of China ; Suzhou Key Medical Center for Psychiatric Diseases ; Suzhou Key laboratory for Biological Psychiatry |
| Funding Project | National Natural Science Foundation of China[81371477] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Key laboratory for Biological Psychiatry[SZS201722] |
| WOS Research Area | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| WOS Subject | Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| WOS ID | WOS:000460476500018 |
| Publisher | SPRINGER |
| WOS Keyword | NEUROTROPHIC FACTOR BDNF ; GROWTH FACTOR INTERACTIONS ; FOOD-INTAKE REGULATION ; VAL66MET POLYMORPHISM ; COGNITIVE FUNCTION ; WEIGHT-GAIN ; BRAIN ; OBESITY ; GENDER ; ESTROGEN |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/28655 |
| Collection | 健康与遗传心理学研究室 |
| Corresponding Author | Lang, XiaoE; Zhang, Xiang Yang |
| Affiliation | 1.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX 77030 USA 2.Anhui Mental Hlth Ctr, Hefei Peoples Hosp 4, Hefei, Anhui, Peoples R China 3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China 4.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China 5.Shanxi Med Univ, Dept Psychiat, Clin Med Coll 1, 85 Jiefang Southern Rd, Taiyuan 030001, Shanxi, Peoples R China 6.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Fang,Wang, Keming,Du, Xiangdong,et al. Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia[J]. PSYCHOPHARMACOLOGY,2019,236(2):753-762. |
| APA | Yang, Fang.,Wang, Keming.,Du, Xiangdong.,Deng, Huiqiong.,Wu, Hanjing Emily.,...&Zhang, Xiang Yang.(2019).Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia.PSYCHOPHARMACOLOGY,236(2),753-762. |
| MLA | Yang, Fang,et al."Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia".PSYCHOPHARMACOLOGY 236.2(2019):753-762. |
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