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Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia
Yang, Fang1; Wang, Keming2; Du, Xiangdong3; Deng, Huiqiong1; Wu, Hanjing Emily1; Yin, Guangzhong3; Ning, Yuping4; Huang, Xingbing4; Teixeira, Antonio L.1; de Quevedo, Joao1; Soares, Jair C.1; Li, Xiaosi2; Lang, XiaoE5; Zhang, Xiang Yang1,6
Corresponding AuthorLang, XiaoE(langxiaoe@yeah.net) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
2019-02-01
Source PublicationPSYCHOPHARMACOLOGY
ISSN0033-3158
Volume236Issue:2Pages:753-762
AbstractRationale and objectiveSchizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex differences in the relationship between serum BDNF levels and obesity in patients with chronic schizophrenia.MethodsWe recruited 132 Chinese patients with chronic schizophrenia (98 males and 34 females) and compared sex differences in the body mass index (BMI), obesity, serum BDNF levels, and their associations. Psychopathology symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). A regression model with various demographic and clinical variables was applied to predict the serum levels of BDNF.ResultsFemale patients had a higher rate of obesity and higher BMI, but lower BDNF levels than male schizophreniapatients. A significantly negative correlation was observed between BMI and BDNF levels only in female patients but not in male patients. The multiple regression model with demographic and clinical variables significantly predicted BDNF levels only in female patients, with a medium size effect. And only in female patients, BMI made a significant contribution to this prediction.ConclusionOur results indicate significant sex differences in the obesity, BMI, BDNF levels, and their association in chronic patients with schizophrenia, showing a significant inverse correlation between BMI and BDNF levels only in female patients. Thus, sex needs to be considered when assessing the relationship between BDNF and metabolic syndromes in schizophrenia.
KeywordSchizophrenia Sex difference Brain-derived neurotrophic factor Obesity Body mass index
DOI10.1007/s00213-018-5107-1
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Suzhou Key Medical Center for Psychiatric Diseases ; Suzhou Key laboratory for Biological Psychiatry
Funding ProjectNational Natural Science Foundation of China[81371477] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Key laboratory for Biological Psychiatry[SZS201722]
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectNeurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000460476500018
PublisherSPRINGER
WOS KeywordNEUROTROPHIC FACTOR BDNF ; GROWTH FACTOR INTERACTIONS ; FOOD-INTAKE REGULATION ; VAL66MET POLYMORPHISM ; COGNITIVE FUNCTION ; WEIGHT-GAIN ; BRAIN ; OBESITY ; GENDER ; ESTROGEN
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28655
Collection健康与遗传心理学研究室
Corresponding AuthorLang, XiaoE; Zhang, Xiang Yang
Affiliation1.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX 77030 USA
2.Anhui Mental Hlth Ctr, Hefei Peoples Hosp 4, Hefei, Anhui, Peoples R China
3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China
4.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China
5.Shanxi Med Univ, Dept Psychiat, Clin Med Coll 1, 85 Jiefang Southern Rd, Taiyuan 030001, Shanxi, Peoples R China
6.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Yang, Fang,Wang, Keming,Du, Xiangdong,et al. Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia[J]. PSYCHOPHARMACOLOGY,2019,236(2):753-762.
APA Yang, Fang.,Wang, Keming.,Du, Xiangdong.,Deng, Huiqiong.,Wu, Hanjing Emily.,...&Zhang, Xiang Yang.(2019).Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia.PSYCHOPHARMACOLOGY,236(2),753-762.
MLA Yang, Fang,et al."Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia".PSYCHOPHARMACOLOGY 236.2(2019):753-762.
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