PSYCH OpenIR  > 健康与遗传心理学研究室
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Huckins, Laura M.1,2,3,4; Dobbyn, Amanda1,2; Ruderfer, Douglas M.5; Hoffman, Gabriel1,4; Wang, Weiqing1,2; Pardinas, Antonio F.6; Rajagopal, Veera M.7,8,9; Als, Thomas D.7,8,9; Nguyen, Hoang T.1,2; Girdhar, Kiran1,2; Boocock, James10; Roussos, Panos1,2,3,4; Fromer, Menachem1,2; Kramer, Robin11; Domenici, Enrico12; Gamazon, Eric R.5,13; Purcell, Shaun1,2,4; Demontis, Ditte7,8,9; Borglum, Anders D.7,8,9; Walters, James T. R.6; O'Donovan, Michael C.6,41; Sullivan, Patrick14,15; Owen, Michael J.6; Devlin, Bernie16; Sieberts, Solveig K.17; Cox, Nancy J.5; Im, Hae Kyung18; Sklar, Pamela1,2,3,4,24; Stahl, Eli A.1,2,3,4; Johnson, Jessica S.1; Shah, Hardik R.2,4; Klein, Lambertus L.16; Dang, Kristen K.17; Logsdon, Benjamin A.17; Mahajan, Milind C.2,4; Mangravite, Lara M.17; Toyoshiba, Hiroyoshi19; Gur, Raquel E.20; Hahn, Chang-Gyu21; Schadt, Eric2,4; Lewis, David A.16; Haroutunian, Vahram1,17,22; Peters, Mette A.17; Lipska, Barbara K.11; Buxbaum, Joseph D.24,25; Hirai, Keisuke26; Perumal, Thanneer M.17; Essioux, Laurent27; Rajagopal, Veera Manikandan7,8,9; Mattheisen, Manuel7,8,9,153; Grove, Jakob7,8,9,28; Werge, Thomas8,29,30; Mortensen, Preben Bo7,8,31,32; Pedersen, Carsten Bocker8,31,32; Agerbo, Esben8,31,32; Pedersen, Marianne Giortz8,31,32; Mors, Ole8,33; Nordentoft, Merete8,34; Hougaard, David M.8,35; Bybjerg-Grauholm, Jonas8,35; Baekvad-Hansen, Marie8,35; Hansen, Christine Soholm8,35; Ripke, Stephan36,37; Neale, Benjamin M.36,37,38,39; Corvin, Aiden40; Farh, Kai-How36; Holmans, Peter A.6,41; Lee, Phil36,37,39; Bulik-Sullivan, Brendan36,37; Collier, David A.42,43; Huang, Hailiang36,38; Pers, Tune H.38,44,45,46; Agartz, Ingrid47,48,49; Albus, Margot50; Alexander, Madeline51; Amin, Farooq52,53; Bacanu, Silviu A.54; Begemann, Martin55; Belliveau, Richard A., Jr.37; Bene, Judit56,57; Bergen, Sarah E.37,58; Bevilacqua, Elizabeth37; Bigdeli, Tim B.54; Black, Donald W.59; Bruggeman, Richard60; Buccola, Nancy G.61; Buckner, Randy L.62,63,64; Byerley, William65; Cahn, Wiepke66; Cai, Guiqing2,3; Campion, Dominique67,68; Cantor, Rita M.10; Carr, Vaughan J.69,70; Carrera, Noa6; Catts, Stanley, V69,71; Chambert, Kimberly D.37; Chan, Raymond C. 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First AuthorLaura M. Huckins
2019-04-01
Source PublicationNATURE GENETICS
Correspondent Emaillaura m. huckins
ISSN1061-4036
SubtypeArticle
Volume51Issue:4Pages:659-+
Abstract

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

DOI10.1038/s41588-019-0364-4
Indexed BySCI
Language英语
Funding Project[R01 MH107666-01] ; Novo Nordisk Foundation ; ARRA Awards[1RC2MH089929-01] ; ARRA Awards[1RC2MH090047-01] ; ARRA Awards[1RC2MH089921-01] ; NINDS ; NIMH ; NIDA ; NHLBI ; NHGRI ; NCI ; Common Fund of the Office of the Director of the National Institutes of Health ; Copenhagen University Hospital ; Aarhus University Hospital ; Copenhagen University ; Aarhus University ; Danish Strategic Research Council ; European Research Council[294838] ; Stanley Medical Research Institute ; Lundbeck Foundation[R155-2014-1724] ; Lundbeck Foundation[R102-A9118] ; Translational Genomics Research Institute ; Illinois Department of Public Health ; NIA[U01AG46152] ; NIA[U01AG32984] ; NIA[R01AG36836] ; NIA[R01AG30146] ; NIA[R01AG17917] ; NIA[R01AG15819] ; NIA[P30AG10161] ; NIH[MH06692] ; NIH[AG05138] ; NIH[AG02219] ; NIH[HHSN271201300031C] ; NIH[R37MH057881S1] ; NIH[R37MH057881] ; NIH[P50MH084053S1] ; NIH[P50M096891] ; NIH[RO1-MH-075916] ; NIH[R01MH097276] ; NIH[P50MH080405] ; NIH[P50MH066392] ; NIH[R01MH093725] ; NIH[R01MH085542] ; F. Hoffman-La Roche Ltd ; Takeda Pharmaceuticals Company Limited
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000462767500013
PublisherNATURE PUBLISHING GROUP
WOS KeywordACUTE INTERMITTENT PORPHYRIA ; COGNITIVE DEFICITS ; ASSOCIATION ; MOUSE ; TRANSCRIPTOME ; CHILDHOOD ; TRAITS ; PSYCHOSIS ; DISORDER ; VARIANTS
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28796
Collection健康与遗传心理学研究室
Corresponding AuthorHuckins, Laura M.; Huckins, Laura M.
Affiliation1.Icahn Sch Med Mt Sinai, Pamela Sklar Div Psychiat Genom, New York, NY 10029 USA
2.Icahn Sch Med Mt Sinai, Dept Genet & Genom, New York, NY 10029 USA
3.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
4.Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA
5.Vanderbilt Univ, Med Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA
6.Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales
7.Aarhus Univ, Dept Biomed, Aarhus, Denmark
8.iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark
9.Aarhus Univ, Ctr Integrat Sequencing, Aarhus, Denmark
10.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
11.NIMH, Human Brain Collect Core, Bethesda, MD 20892 USA
12.Univ Trento, Ctr Integrat Biol CIBIO, Lab Neurogen Biomarkers, Trento, Italy
13.Univ Cambridge, Clare Hall, Cambridge, England
14.Univ North Carolina Chapel Hill, Chapel Hill, NC USA
15.Karolinska Inst, Stockholm, Sweden
16.Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA
17.Sage Bionetworks, Syst Biol, Seattle, WA USA
18.Univ Chicago, Dept Med, Sect Genet Med, 5841 S Maryland Ave, Chicago, IL 60637 USA
19.Takeda Pharmaceut Co Ltd, Pharmaceut Res Div, Integrated Technol Res Labs, Fujisawa, Kanagawa, Japan
20.Univ Penn, Dept Psychiat, Neuropsychiat Sect, Perelman Sch Med, Philadelphia, PA 19104 USA
21.Univ Penn, Dept Psychiat, Perelman Sch Med, Neuropsychiat Signaling Program, Philadelphia, PA 19104 USA
22.JJ Peters Virginia Med Ctr, Psychiat, Bronx, NY USA
23.Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA
24.Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA
25.Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
26.Takeda Pharmaceut Co Ltd, CNS Drug Discovery Unit, Pharmaceut Res Div, Fujisawa, Kanagawa, Japan
27.Hoffman Roche Ltd, Basel, Switzerland
28.Aarhus Univ, Bioinformat Res Ctr, Aarhus, Denmark
29.Mental Hlth Serv Copenhagen, Inst Biol Psychiat, MHC Sct Hans, Roskilde, Denmark
30.Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
31.Aarhus Univ, Natl Ctr Register Based Res, Aarhus, Denmark
32.Aarhus Univ, Ctr Integrated Register Based Res, Aarhus, Denmark
33.Aarhus Univ Hosp, Psychosis Res Unit, Risskov, Denmark
34.Univ Copenhagen, Mental Hlth Ctr Copenhagen, Mental Hlth Serv Capital Reg Denmark, Copenhagen, Denmark
35.Statens Serum Inst, Ctr Neonatal Screening, Dept Congenital Disorders, Copenhagen, Denmark
36.Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
37.Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA USA
38.Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA USA
39.Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA
40.Trinity Coll Dublin, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin, Ireland
41.Cardiff Univ, Natl Ctr Mental Hlth, Cardiff, S Glam, Wales
42.Eli Lilly & Co Ltd, Erl Wood Manor Sunninghill Rd, Windlesham, Surrey, England
43.Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat, London, England
44.Tech Univ Denmark, Ctr BiologicalSequence Anal, Dept Syst Biol, Lyngby, Denmark
45.Boston Childrens Hosp, Div Endocrinol, Boston, MA USA
46.Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA
47.Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, Stockholm, Sweden
48.Diakonhjemmet Hosp, Dept Psychiat, Oslo, Norway
49.Univ Oslo, KG Jebsen Ctr Psychosis Res, Inst Clin Med, NORMENT, Oslo, Norway
50.State Mental Hosp, Haar, Germany
51.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
52.Atlanta Vet Affairs Med Ctr, Dept Psychiat & Behav Sci, Atlanta, GA USA
53.Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
54.Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Psychiat, Richmond, VA USA
55.Max Planck Inst Expt Med, Clin Neurosci, Gottingen, Germany
56.Univ Pecs, Dept Med Genet, Pecs, Hungary
57.Univ Pecs, Szentagothai Res Ctr, Pecs, Hungary
58.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
59.Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA
60.Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
61.Louisiana State Univ, Hlth Sci Ctr, Sch Nursing, New Orleans, LA USA
62.Massachusetts Gen Hosp, Athinoula Martinos Ctr, Boston, MA 02114 USA
63.Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA
64.Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
65.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
66.Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, Utrecht, Netherlands
67.Ctr Hosp Rouvray, Rouen, France
68.INSERM, U 1079, Fac Med, Rouen, France
69.Schizophrenia Res Inst, Sydney, NSW, Australia
70.Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia
71.Univ Queensland, Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia
72.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
73.Univ Hong Kong, Li Ka Shing Fac Med, Dept Psychiat, Hong Kong, Peoples R China
74.Univ Hong Kong, Li Ka Shing Fac Med, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China
75.Castle Peak Hosp, Hong Kong, Peoples R China
76.Inst Mental Hlth, Singapore, Singapore
77.Washington Univ, Dept Psychiat, St Louis, MO USA
78.Pierre & Marie Curie Fac Med, Dept Child & Adolescent Psychiat, AP HP, Paris, France
79.Inst Intelligent Syst & Robot, Paris, France
80.Blue Note Biosci, Princeton, NJ USA
81.Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA
82.Queen Mary Univ London, Dept Psychol Med, London, England
83.UCL, Div Psychiat, Mol Psychiat Lab, London, England
84.Sheba Med Ctr, Tel Hashomer, Israel
85.Life & Brain Ctr, Dept Genom, Bonn, Germany
86.Univ Bonn, Inst Human Genet, Bonn, Germany
87.Univ Antwerp, VIB Dept Mol Genet, Appl Mol Genom Unit, Antwerp, Belgium
88.Univ Athens, Dept Psychiat 1, Med Sch, Athens, Greece
89.Univ Coll Cork, Dept Psychiat, Cork, CO, Ireland
90.Oslo Univ Hosp, Dept Med Genet, Oslo, Norway
91.Natl Univ Ireland Galway, Sch Psychol & Discipline Biochem, Cognit Genet & Therapy Grp, Galway, CO, Ireland
92.Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA
93.North Shore Univ Hlth Syst, Dept Psychiat & Behav Sci, Evanston, IL USA
94.London Sch Hyg & Trop Med, Dept Non Communicable Dis Epidemiol, London, England
95.Univ Clin Psychiat, Dept Child & Adolescent Psychiat, Skopje, Macedonia
96.Univ Regensburg, Dept Psychiat, Regensburg, Germany
97.Univ Helsinki, Helsinki Univ Cent Hosp, Dept Gen Practice, Helsinki, Finland
98.Folkhalsan Res Ctr, Biomed Helsinki, Helsinki, Finland
99.Natl Inst Hlth & Welf, Helsinki, Finland
100.F Hoffmann La Roche & Cie AG, Pharma Res & Early Dev, Translat Technol & Bioinformat, Basel, Switzerland
101.Georgetown Univ, Dept Psychiat, Sch Med, Washington, DC USA
102.Univ Southern Calif, Dept Psychiat, Keck Sch Med, Los Angeles, CA USA
103.Virginia Commonwealth Univ, Sch Med, Dept Psychiat, Richmond, VA USA
104.Washington VA Med Ctr, Mental Hlth Serv Line, Washington, DC USA
105.Heidelberg Univ, Med Fac Mannhe, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany
106.Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands
107.Univ Colorado Denver, Dept Psychiat, Aurora, CO USA
108.Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90024 USA
109.Univ Halle, Dept Psychiat, Halle, Germany
110.Univ Munich, Dept Psychiat, Munich, Germany
111.Hop La Pitie Salpetriere, Dept Psychiat, Inst Myol, INSERM, Paris, France
112.Hop La Pitie Salpetriere, Dept Human, Inst Myol, INSERM, Paris, France
113.Hop La Pitie Salpetriere, Dept Mol Genet, Inst Myol, INSERM, Paris, France
114.Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow, Russia
115.Janssen Res & Dev, Neurosci Therapeut Area, Raritan, NJ USA
116.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
117.Acad Med Ctr Univ Amsterdam, Dept Psychiat, Amsterdam, Netherlands
118.Illumina, La Jolla, CA USA
119.Univ Newcastle, Prior Res Ctr Hlth Behav, Newcastle, NSW, Australia
120.Univ Newcastle, Sch Elect Engn & Comp Sci, Newcastle, NSW, Australia
121.Univ Basel, Dept Biomed, Div Med Genet, Basel, Switzerland
122.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA
123.Fujita Hlth Univ, Dept Psychiat, Sch Med, Toyoake, Aichi, Japan
124.Stavanger Univ Hosp, Reg Ctr Clin Researchin Psychosis, Dept Psychiat, Stavanger, Norway
125.Vail dHebron Res Inst, Rheumatol Res Grp, Barcelona, Spain
126.Univ Western Australia, Ctr Med Res, Perth, WA, Australia
127.Univ Western Australia, Perkins Inst Med Res, Perth, WA, Australia
128.Med Univ, Dept Med Genet, Sofia, Bulgaria
129.Univ Colorado, Dept Psychol, Campus Box 345, Boulder, CO 80309 USA
130.Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada
131.Univ Toronto, Dept Psychiat, Toronto, ON, Canada
132.Univ Toronto, Inst Med Sci, Toronto, ON, Canada
133.Russian Acad Sci, Inst Mol Genet, Moscow, Russia
134.Latvian Biomed Res & Study Ctr, Riga, Latvia
135.Univ Southern Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA USA
136.Vilnius Univ, Fac Med, Vilnius, Lithuania
137.2nd Fac Med, Dept Biol & Med Genet, Prague, Czech Republic
138.Univ Hosp Motol, Prague, Czech Republic
139.Pierre & Marie Curie Fac Med, Dept Child & Adolescent Psychiat, Paris, France
140.Duke NUS Grad Med Sch, Singapore, Singapore
141.Hadassah Hebrew Univ, Dept Psychiat, Med Ctr, Jerusalem, Israel
142.Univ Hong Kong, Ctr Genom Sci, Hong Kong, Peoples R China
143.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China
144.Sichuan Univ, West China Hosp, Psychiat Lab, Chengdu, Sichuan, Peoples R China
145.Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA
146.Columbia Univ, Dept Psychiat, New York, NY USA
147.Univ Newcastle, Prior Ctr Translat Neurosci & Mental Hlth, Newcastle, NSW, Australia
148.Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland
149.Natl Inst Hlth & Welf, Dept Mental Hlth & Subst Abuse Serv, Helsinki, Finland
150.Johns Hopkins Univ, Dept Mental Hlth, Bloomberg Sch Publ Hlth, Baltimore, MD USA
151.Univ Bonn, Dept Psychiat, Bonn, Germany
152.Hop La Pitie Salpetriere, Lab Genet Mol Neurotransmiss & Processus Neuroden, Ctr Natl Rech Sci, Paris, France
153.Univ Bonn, Dept Genom Math, Bonn, Germany
154.Sorlandet Hosp, Res Unit, Kristiansand, Norway
155.Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA
156.VA Boston Hlth Care Syst, Brockton, MA USA
157.Natl Univ Ireland Galway, Dept Psychiat, Galway, CO, Ireland
158.Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland
159.Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
160.Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
161.Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div, Boston, MA 02215 USA
162.Univ Tartu, Estonian Genome Ctr, Tartu, Estonia
163.Univ Newcastle, Sch Psychol, Newcastle, NSW, Australia
164.Med Univ, Psychiat Clin 1, Sofia, Bulgaria
165.Aarhus Univ Hosp, Dept P, Risskov, Denmark
166.Royal Coll Surgeons Ireland, Dept Psychiat, Dublin, Ireland
167.Kings Coll London, London, England
168.Maastricht Univ, Med Ctr, EURON, South Limburg Mental Hlth Res & TeachingNetwork, Maastricht, Netherlands
169.Univ Liverpool, Inst Translat Med, Liverpool, Merseyside, England
170.Max Planck Inst Psychiat, Munich, Germany
171.Munich Cluster Syst Neurol SyNergy, Munich, Germany
172.Jena Univ Hosp, Dept Psychiat & Psychotherapy, Jena, Germany
173.Univ Queensland, Queensland Brain Inst, Dept Psychiat, Brisbane, Qld, Australia
174.Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia
175.Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
176.Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland
177.Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA
178.Umea Univ, Dept Clin Sci, Psychiat, Umea, Sweden
179.Blackrock Co, DETECT Early Intervent Serv Psychosis, Dublin, Ireland
180.Queens Univ Belfast, Ctr Publ Hlth, Inst Clin Sci, Belfast, Antrim, North Ireland
181.Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA
182.Kings Coll London, Inst Psychiat, London, England
183.Univ Melbourne & Melbourne Hlth, Melbourne Neuropsychiat Ctr, Victoria, Australia
184.Univ Helsinki, Dept Psychiat, Helsinki, Finland
185.Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland
186.Univ Belgrade, Med Fac, Belgrade, Serbia
187.Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA
188.Univ Helsinki, Inst Mol Med Finland, FIMM, Helsinki, Finland
189.Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
190.Univ Oxford, Dept Psychiat, Oxford, England
191.Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
192.Pfizer Worldwide Res & Dev, Pharma Therapeut Clin Res, Cambridge, MA USA
193.Univ Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
194.Univ Erlangen Nurnberg, Psychiat & Psychotherapy Clin, Erlangen, Germany
195.Hunter New England Hlth Serv, Newcastle, NSW, Australia
196.Univ Newcastle, Sch Biomed Sci, Newcastle, NSW, Australia
197.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
198.Univ Iceland, Natl Univ Hosp, Landspitali, Reykjavik, Iceland
199.Tbilisi State Med Univ, Dept Psychiat & Drug Addict, Tbilisi, Rep of Georgia
200.Bronx Vet Affairs Med Ctr, Res & Dev, New York, NY USA
201.WellcomeTrust Ctr Human Genet, Oxford, England
202.deCODE Genet, Reykjavik, Iceland
203.Med Univ Vienna, Dept Clin Neurol, Vienna, Austria
204.Lieber Inst Brain Dev, Baltimore, MD USA
205.Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
206.Berkshire Healthcare NHS Fdn Trust, Bracknell, Berks, England
207.Univ Verona, Sect Psychiat, Verona, Italy
208.Univ Oulu, Dept Psychiat, Oulu, Finland
209.Univ Hosp Oulu, Oulu, Finland
210.Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin, Ireland
211.Hlth Res Board, Dublin, Ireland
212.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA, Australia
213.Pfizer Worldwide Res & Dev, Computat Sci CoE, Cambridge, MA USA
214.ASTAR, Genome Inst Singapore, Human Genet, Singapore, Singapore
215.UCL, London, England
216.Res Ctr Juelich, Inst Neurosci & Med INM 1, Julich, Germany
217.Hebrew Univ Jerusalem, Dept Genet, Jerusalem, Israel
218.Hoffman Roche, Pharma Res & Early Dev, NeuroscienceDiscovery & Translat Area, Basel, Switzerland
219.Univ Western Australia, Ctr Clin Res Neuropsychiat, Sch Psychiat & Clin Neurosci, Med Res Fdn Bldg, Perth, WA, Australia
220.Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Human & Mol Genet, Richmond, VA USA
221.Feinstein Inst Med Res, Manhasset, NY USA
222.Hofstra NS LIJ Sch Med, Hempstead, NY USA
223.Zucker Hillside Hosp, Glen Oaks, NY USA
224.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
225.Massachusetts Gen Hosp, Ctr HumanGenet Res & Dept Psychiat, Boston, MA 02114 USA
226.Erasmus MC, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands
227.VU Univ Med Ctr Amsterdam, Dept Complex Trait Genet, Neurosci Campus Amsterda, Amsterdam, Netherlands
228.Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Funct Genom, Neurosci Campus Amsterdam, Amsterdam, Netherlands
229.Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland
230.Johns Hopkins Sch Med, Neurosci & Inst Genet Med, Dept Psychiat, Neurol, Baltimore, MD USA
231.Icahn Sch Med Mt Sinai, Pamela Sklar Div Psychiat Genom, New York, NY 10029 USA
232.Icahn Sch Med Mt Sinai, Dept Genet & Genom, New York, NY 10029 USA
233.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
234.Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA
235.Vanderbilt Univ, Med Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA
236.Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales
237.Aarhus Univ, Dept Biomed, Aarhus, Denmark
238.iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark
239.Aarhus Univ, Ctr Integrat Sequencing, Aarhus, Denmark
240.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
241.NIMH, Human Brain Collect Core, Bethesda, MD 20892 USA
242.Univ Trento, Ctr Integrat Biol CIBIO, Lab Neurogen Biomarkers, Trento, Italy
243.Univ Cambridge, Clare Hall, Cambridge, England
244.Univ North Carolina Chapel Hill, Chapel Hill, NC USA
245.Karolinska Inst, Stockholm, Sweden
246.Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA
247.Sage Bionetworks, Syst Biol, Seattle, WA USA
248.Univ Chicago, Dept Med, Sect Genet Med, 5841 S Maryland Ave, Chicago, IL 60637 USA
249.Takeda Pharmaceut Co Ltd, Pharmaceut Res Div, Integrated Technol Res Labs, Fujisawa, Kanagawa, Japan
250.Univ Penn, Dept Psychiat, Neuropsychiat Sect, Perelman Sch Med, Philadelphia, PA 19104 USA
251.Univ Penn, Dept Psychiat, Perelman Sch Med, Neuropsychiat Signaling Program, Philadelphia, PA 19104 USA
252.JJ Peters Virginia Med Ctr, Psychiat, Bronx, NY USA
253.Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA
254.Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA
255.Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
256.Takeda Pharmaceut Co Ltd, CNS Drug Discovery Unit, Pharmaceut Res Div, Fujisawa, Kanagawa, Japan
257.Hoffman Roche Ltd, Basel, Switzerland
258.Aarhus Univ, Bioinformat Res Ctr, Aarhus, Denmark
259.Mental Hlth Serv Copenhagen, Inst Biol Psychiat, MHC Sct Hans, Roskilde, Denmark
260.Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
261.Aarhus Univ, Natl Ctr Register Based Res, Aarhus, Denmark
262.Aarhus Univ, Ctr Integrated Register Based Res, Aarhus, Denmark
263.Aarhus Univ Hosp, Psychosis Res Unit, Risskov, Denmark
264.Univ Copenhagen, Mental Hlth Ctr Copenhagen, Mental Hlth Serv Capital Reg Denmark, Copenhagen, Denmark
265.Statens Serum Inst, Ctr Neonatal Screening, Dept Congenital Disorders, Copenhagen, Denmark
266.Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
267.Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA USA
268.Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA USA
269.Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA
270.Trinity Coll Dublin, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin, Ireland
271.Cardiff Univ, Natl Ctr Mental Hlth, Cardiff, S Glam, Wales
272.Eli Lilly & Co Ltd, Erl Wood Manor Sunninghill Rd, Windlesham, Surrey, England
273.Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat, London, England
274.Tech Univ Denmark, Ctr BiologicalSequence Anal, Dept Syst Biol, Lyngby, Denmark
275.Boston Childrens Hosp, Div Endocrinol, Boston, MA USA
276.Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA
277.Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, Stockholm, Sweden
278.Diakonhjemmet Hosp, Dept Psychiat, Oslo, Norway
279.Univ Oslo, KG Jebsen Ctr Psychosis Res, Inst Clin Med, NORMENT, Oslo, Norway
280.State Mental Hosp, Haar, Germany
281.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
282.Atlanta Vet Affairs Med Ctr, Dept Psychiat & Behav Sci, Atlanta, GA USA
283.Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
284.Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Psychiat, Richmond, VA USA
285.Max Planck Inst Expt Med, Clin Neurosci, Gottingen, Germany
286.Univ Pecs, Dept Med Genet, Pecs, Hungary
287.Univ Pecs, Szentagothai Res Ctr, Pecs, Hungary
288.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
289.Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA
290.Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
291.Louisiana State Univ, Hlth Sci Ctr, Sch Nursing, New Orleans, LA USA
292.Massachusetts Gen Hosp, Athinoula Martinos Ctr, Boston, MA 02114 USA
293.Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA
294.Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
295.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
296.Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, Utrecht, Netherlands
297.Ctr Hosp Rouvray, Rouen, France
298.INSERM, U 1079, Fac Med, Rouen, France
299.Schizophrenia Res Inst, Sydney, NSW, Australia
300.Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia
301.Univ Queensland, Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia
302.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
303.Univ Hong Kong, Li Ka Shing Fac Med, Dept Psychiat, Hong Kong, Peoples R China
304.Univ Hong Kong, Li Ka Shing Fac Med, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China
305.Castle Peak Hosp, Hong Kong, Peoples R China
306.Inst Mental Hlth, Singapore, Singapore
307.Washington Univ, Dept Psychiat, St Louis, MO USA
308.Pierre & Marie Curie Fac Med, Dept Child & Adolescent Psychiat, AP HP, Paris, France
309.Inst Intelligent Syst & Robot, Paris, France
310.Blue Note Biosci, Princeton, NJ USA
311.Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA
312.Queen Mary Univ London, Dept Psychol Med, London, England
313.UCL, Div Psychiat, Mol Psychiat Lab, London, England
314.Sheba Med Ctr, Tel Hashomer, Israel
315.Life & Brain Ctr, Dept Genom, Bonn, Germany
316.Univ Bonn, Inst Human Genet, Bonn, Germany
317.Univ Antwerp, VIB Dept Mol Genet, Appl Mol Genom Unit, Antwerp, Belgium
318.Univ Athens, Dept Psychiat 1, Med Sch, Athens, Greece
319.Univ Coll Cork, Dept Psychiat, Cork, CO, Ireland
320.Oslo Univ Hosp, Dept Med Genet, Oslo, Norway
321.Natl Univ Ireland Galway, Sch Psychol & Discipline Biochem, Cognit Genet & Therapy Grp, Galway, CO, Ireland
322.Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA
323.North Shore Univ Hlth Syst, Dept Psychiat & Behav Sci, Evanston, IL USA
324.London Sch Hyg & Trop Med, Dept Non Communicable Dis Epidemiol, London, England
325.Univ Clin Psychiat, Dept Child & Adolescent Psychiat, Skopje, Macedonia
326.Univ Regensburg, Dept Psychiat, Regensburg, Germany
327.Univ Helsinki, Helsinki Univ Cent Hosp, Dept Gen Practice, Helsinki, Finland
328.Folkhalsan Res Ctr, Biomed Helsinki, Helsinki, Finland
329.Natl Inst Hlth & Welf, Helsinki, Finland
330.F Hoffmann La Roche & Cie AG, Pharma Res & Early Dev, Translat Technol & Bioinformat, Basel, Switzerland
331.Georgetown Univ, Dept Psychiat, Sch Med, Washington, DC USA
332.Univ Southern Calif, Dept Psychiat, Keck Sch Med, Los Angeles, CA USA
333.Virginia Commonwealth Univ, Sch Med, Dept Psychiat, Richmond, VA USA
334.Washington VA Med Ctr, Mental Hlth Serv Line, Washington, DC USA
335.Heidelberg Univ, Med Fac Mannhe, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany
336.Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands
337.Univ Colorado Denver, Dept Psychiat, Aurora, CO USA
338.Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90024 USA
339.Univ Halle, Dept Psychiat, Halle, Germany
340.Univ Munich, Dept Psychiat, Munich, Germany
341.Hop La Pitie Salpetriere, Dept Psychiat, Inst Myol, INSERM, Paris, France
342.Hop La Pitie Salpetriere, Dept Human, Inst Myol, INSERM, Paris, France
343.Hop La Pitie Salpetriere, Dept Mol Genet, Inst Myol, INSERM, Paris, France
344.Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow, Russia
345.Janssen Res & Dev, Neurosci Therapeut Area, Raritan, NJ USA
346.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
347.Acad Med Ctr Univ Amsterdam, Dept Psychiat, Amsterdam, Netherlands
348.Illumina, La Jolla, CA USA
349.Univ Newcastle, Prior Res Ctr Hlth Behav, Newcastle, NSW, Australia
350.Univ Newcastle, Sch Elect Engn & Comp Sci, Newcastle, NSW, Australia
351.Univ Basel, Dept Biomed, Div Med Genet, Basel, Switzerland
352.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA
353.Fujita Hlth Univ, Dept Psychiat, Sch Med, Toyoake, Aichi, Japan
354.Stavanger Univ Hosp, Reg Ctr Clin Researchin Psychosis, Dept Psychiat, Stavanger, Norway
355.Vail dHebron Res Inst, Rheumatol Res Grp, Barcelona, Spain
356.Univ Western Australia, Ctr Med Res, Perth, WA, Australia
357.Univ Western Australia, Perkins Inst Med Res, Perth, WA, Australia
358.Med Univ, Dept Med Genet, Sofia, Bulgaria
359.Univ Colorado, Dept Psychol, Campus Box 345, Boulder, CO 80309 USA
360.Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada
361.Univ Toronto, Dept Psychiat, Toronto, ON, Canada
362.Univ Toronto, Inst Med Sci, Toronto, ON, Canada
363.Russian Acad Sci, Inst Mol Genet, Moscow, Russia
364.Latvian Biomed Res & Study Ctr, Riga, Latvia
365.Univ Southern Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA USA
366.Vilnius Univ, Fac Med, Vilnius, Lithuania
367.2nd Fac Med, Dept Biol & Med Genet, Prague, Czech Republic
368.Univ Hosp Motol, Prague, Czech Republic
369.Pierre & Marie Curie Fac Med, Dept Child & Adolescent Psychiat, Paris, France
370.Duke NUS Grad Med Sch, Singapore, Singapore
371.Hadassah Hebrew Univ, Dept Psychiat, Med Ctr, Jerusalem, Israel
372.Univ Hong Kong, Ctr Genom Sci, Hong Kong, Peoples R China
373.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China
374.Sichuan Univ, West China Hosp, Psychiat Lab, Chengdu, Sichuan, Peoples R China
375.Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA
376.Columbia Univ, Dept Psychiat, New York, NY USA
377.Univ Newcastle, Prior Ctr Translat Neurosci & Mental Hlth, Newcastle, NSW, Australia
378.Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland
379.Natl Inst Hlth & Welf, Dept Mental Hlth & Subst Abuse Serv, Helsinki, Finland
380.Johns Hopkins Univ, Dept Mental Hlth, Bloomberg Sch Publ Hlth, Baltimore, MD USA
381.Univ Bonn, Dept Psychiat, Bonn, Germany
382.Hop La Pitie Salpetriere, Lab Genet Mol Neurotransmiss & Processus Neuroden, Ctr Natl Rech Sci, Paris, France
383.Univ Bonn, Dept Genom Math, Bonn, Germany
384.Sorlandet Hosp, Res Unit, Kristiansand, Norway
385.Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA
386.VA Boston Hlth Care Syst, Brockton, MA USA
387.Natl Univ Ireland Galway, Dept Psychiat, Galway, CO, Ireland
388.Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland
389.Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
390.Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
391.Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div, Boston, MA 02215 USA
392.Univ Tartu, Estonian Genome Ctr, Tartu, Estonia
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400.Max Planck Inst Psychiat, Munich, Germany
401.Munich Cluster Syst Neurol SyNergy, Munich, Germany
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404.Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia
405.Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
406.Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland
407.Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA
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415.Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland
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418.Univ Helsinki, Inst Mol Med Finland, FIMM, Helsinki, Finland
419.Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
420.Univ Oxford, Dept Psychiat, Oxford, England
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422.Pfizer Worldwide Res & Dev, Pharma Therapeut Clin Res, Cambridge, MA USA
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424.Univ Erlangen Nurnberg, Psychiat & Psychotherapy Clin, Erlangen, Germany
425.Hunter New England Hlth Serv, Newcastle, NSW, Australia
426.Univ Newcastle, Sch Biomed Sci, Newcastle, NSW, Australia
427.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
428.Univ Iceland, Natl Univ Hosp, Landspitali, Reykjavik, Iceland
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430.Bronx Vet Affairs Med Ctr, Res & Dev, New York, NY USA
431.WellcomeTrust Ctr Human Genet, Oxford, England
432.deCODE Genet, Reykjavik, Iceland
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436.Berkshire Healthcare NHS Fdn Trust, Bracknell, Berks, England
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438.Univ Oulu, Dept Psychiat, Oulu, Finland
439.Univ Hosp Oulu, Oulu, Finland
440.Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin, Ireland
441.Hlth Res Board, Dublin, Ireland
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445.UCL, London, England
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Recommended Citation
GB/T 7714
Huckins, Laura M.,Dobbyn, Amanda,Ruderfer, Douglas M.,et al. Gene expression imputation across multiple brain regions provides insights into schizophrenia risk[J]. NATURE GENETICS,2019,51(4):659-+.
APA Huckins, Laura M..,Dobbyn, Amanda.,Ruderfer, Douglas M..,Hoffman, Gabriel.,Wang, Weiqing.,...&Sullivan, Patrick F..(2019).Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.NATURE GENETICS,51(4),659-+.
MLA Huckins, Laura M.,et al."Gene expression imputation across multiple brain regions provides insights into schizophrenia risk".NATURE GENETICS 51.4(2019):659-+.
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