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A Conflict Model of Reward-seeking Behavior in Male Rats
Jiang, Shaofei1,2; Zhang, Yue1,2; Zheng, Xigeng1,2; Luo, Haoshuang1,2; Liu, Zhengkui1,2; Bai, Yunjing1,2
First AuthorShaofei Jiang
2019-02-01
Source PublicationJOVE-JOURNAL OF VISUALIZED EXPERIMENTS
Correspondent Emailzhengkui liu at liuzk@psych.ac.cn ; yunjing bai at baiyj@psych.ac.cn
ISSN1940-087X
SubtypeArticle
Issue144Pages:8
Contribution Rank1
Abstract

The present protocol describes a novel conflict task as a model of inhibitory control in rats. In this model, a natural rewarding stimulus (sexual stimulus) that represents a high-value reward, and the aversive stimuli (pins), are concurrently presented. The male rats have to climb or jump over the obstacle full of pins to approach and investigate the sexual partner. If the animal persists in their approaching behavior regardless of the aversive stimuli, it is considered as a maladaptive or risky reward-seeking behavior. The conflict task permits the evaluation of deficit in inhibitory control resulting from exposure to abused drug, such as morphine, or a stressful event. The main advantage of this model is that it provides a simple and quick way to discover the deficit in inhibitory control after exposure to opiate drugs or other stressful events. In addition to opiates, this behavioral model would also be useful for quickly discovering the inhibitory control deficits induced by other addictive drugs. However, the limitation is that the male rats' performance may be subject to exercising effects with repeated testing under this conflict task. In the future, one can hope that the individuals with the compulsive phenotype of reward-seeking behavior after exposure to opiates will be identified based on modifying this conflict model.

KeywordRetraction Issue 144 morphine withdrawal conflict inhibitory control sexual reward stress
DOI10.3791/59141
Indexed BySCI
Language英语
Funding ProjectEvaluation and Intervention Technology Research for Post-traumatic Stress Patients Population[JCYJ20170413170301569] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016K01]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000462905000067
PublisherJOURNAL OF VISUALIZED EXPERIMENTS
WOS KeywordLONG-TERM WITHDRAWAL ; ORBITOFRONTAL CORTEX ; OPIOID RECEPTORS ; NEURAL BASIS ; ADDICTION ; TASK ; IMPULSIVITY ; INHIBITION ; MECHANISMS ; DEFICITS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28802
Collection中国科学院心理健康重点实验室
Corresponding AuthorLiu, Zhengkui; Bai, Yunjing
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Jiang, Shaofei,Zhang, Yue,Zheng, Xigeng,et al. A Conflict Model of Reward-seeking Behavior in Male Rats[J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS,2019(144):8.
APA Jiang, Shaofei,Zhang, Yue,Zheng, Xigeng,Luo, Haoshuang,Liu, Zhengkui,&Bai, Yunjing.(2019).A Conflict Model of Reward-seeking Behavior in Male Rats.JOVE-JOURNAL OF VISUALIZED EXPERIMENTS(144),8.
MLA Jiang, Shaofei,et al."A Conflict Model of Reward-seeking Behavior in Male Rats".JOVE-JOURNAL OF VISUALIZED EXPERIMENTS .144(2019):8.
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