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Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies | |
Cao, Cong1; Cao, Lili2; Chen, Jie3 | |
第一作者 | Cong Cao |
通讯作者邮箱 | caocong@sdu.edu.cn ; chenjie@psych.ac.cn |
心理所单位排序 | 3 |
摘要 | To date, several gene-by-environment (GxE) meta-analyses have been conducted to provide cumulative GxE evidence from previous inconsistent empirical studies; however, these meta-analyses have mainly focused on the serotonin transporter gene (5-HTTLPR). The present study aimed to conduct the first meta-analysis that tested whether and how an important dopaminergic genethe catechol-O-methyltransferase (COMT) gene contributed to differences in child and adolescent environmental sensitivity. A total of 22 studies with 20,528 participants involving in various developmental outcomes (e.g., externalizing problems, emotional problems, cognitive development and social behaviors) met the inclusion criteria. The pooled effect size of environment-outcome associations in the Met-allele carriers (r=0.11, 95% CI=[0.07, 0.15], p<.001) did not significantly differ from that in the Val/Val homozygotes (r=0.14, 95% CI=[0.08, 0.20], p<0.001) (Q(contrast) (1)=0.37, p=0.54). The aggregated Liptak-Stouffer Z-score that combined the p-values of the COMT-environment interaction yield a nonsignificant result (p=0.52). Moreover, outcome domain, sample age, ethnicity and assessment methods for the environment and the outcome did not moderate the effect sizes. Thus far, the COMT Val158Met polymorphism fails to explain the differences in sensitivity to environment. Future studies might incorporate more factors, such as polygenic effects of genetic pathways, epigenetics (EpiG) processing and sexual dimorphism, into the COMT-environment interaction equation. |
关键词 | Meta-analysis COMT Gene-by-environment interaction (GxE) Child Adolescent |
2019-04-01 | |
语种 | 英语 |
DOI | 10.1007/s10964-019-01004-3 |
发表期刊 | JOURNAL OF YOUTH AND ADOLESCENCE |
ISSN | 0047-2891 |
卷号 | 48期号:4页码:655-667 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | Fundamental Research Funds of Shandong University[2018GN022] ; Social Science Planning Fund of Shandong Province[17CSZJ01] ; National Natural Science Foundation of China[31800936] |
出版者 | SPRINGER/PLENUM PUBLISHERS |
WOS关键词 | SEROTONIN TRANSPORTER GENE ; VAL158MET POLYMORPHISM ; ANTISOCIAL-BEHAVIOR ; BIRTH-WEIGHT ; LIFE EVENTS ; STRESS ; BRAIN ; GENOTYPE ; SUSCEPTIBILITY ; DEPRESSION |
WOS研究方向 | Psychology |
WOS类目 | Psychology, Developmental |
WOS记录号 | WOS:000462930000002 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/28814 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Cao, Cong; Chen, Jie |
作者单位 | 1.Shandong Univ, Sch Nursing, Jinan, Shandong, Peoples R China 2.Shandong Univ, Student Counseling Ctr, Jinan, Shandong, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Cao, Cong,Cao, Lili,Chen, Jie. Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies[J]. JOURNAL OF YOUTH AND ADOLESCENCE,2019,48(4):655-667. |
APA | Cao, Cong,Cao, Lili,&Chen, Jie.(2019).Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies.JOURNAL OF YOUTH AND ADOLESCENCE,48(4),655-667. |
MLA | Cao, Cong,et al."Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies".JOURNAL OF YOUTH AND ADOLESCENCE 48.4(2019):655-667. |
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