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Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies
Cao, Cong1; Cao, Lili2; Chen, Jie3
First AuthorCong Cao
2019-04-01
Source PublicationJOURNAL OF YOUTH AND ADOLESCENCE
Correspondent Emailcaocong@sdu.edu.cn ; chenjie@psych.ac.cn
ISSN0047-2891
SubtypeArticle
Volume48Issue:4Pages:655-667
Contribution Rank3
Abstract

To date, several gene-by-environment (GxE) meta-analyses have been conducted to provide cumulative GxE evidence from previous inconsistent empirical studies; however, these meta-analyses have mainly focused on the serotonin transporter gene (5-HTTLPR). The present study aimed to conduct the first meta-analysis that tested whether and how an important dopaminergic genethe catechol-O-methyltransferase (COMT) gene contributed to differences in child and adolescent environmental sensitivity. A total of 22 studies with 20,528 participants involving in various developmental outcomes (e.g., externalizing problems, emotional problems, cognitive development and social behaviors) met the inclusion criteria. The pooled effect size of environment-outcome associations in the Met-allele carriers (r=0.11, 95% CI=[0.07, 0.15], p<.001) did not significantly differ from that in the Val/Val homozygotes (r=0.14, 95% CI=[0.08, 0.20], p<0.001) (Q(contrast) (1)=0.37, p=0.54). The aggregated Liptak-Stouffer Z-score that combined the p-values of the COMT-environment interaction yield a nonsignificant result (p=0.52). Moreover, outcome domain, sample age, ethnicity and assessment methods for the environment and the outcome did not moderate the effect sizes. Thus far, the COMT Val158Met polymorphism fails to explain the differences in sensitivity to environment. Future studies might incorporate more factors, such as polygenic effects of genetic pathways, epigenetics (EpiG) processing and sexual dimorphism, into the COMT-environment interaction equation.

KeywordMeta-analysis COMT Gene-by-environment interaction (GxE) Child Adolescent
DOI10.1007/s10964-019-01004-3
Indexed BySCI
Language英语
Funding ProjectFundamental Research Funds of Shandong University[2018GN022] ; Social Science Planning Fund of Shandong Province[17CSZJ01] ; National Natural Science Foundation of China[31800936]
WOS Research AreaPsychology
WOS SubjectPsychology, Developmental
WOS IDWOS:000462930000002
PublisherSPRINGER/PLENUM PUBLISHERS
WOS KeywordSEROTONIN TRANSPORTER GENE ; VAL158MET POLYMORPHISM ; ANTISOCIAL-BEHAVIOR ; BIRTH-WEIGHT ; LIFE EVENTS ; STRESS ; BRAIN ; GENOTYPE ; SUSCEPTIBILITY ; DEPRESSION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28814
Collection中国科学院心理健康重点实验室
Corresponding AuthorCao, Cong; Chen, Jie
Affiliation1.Shandong Univ, Sch Nursing, Jinan, Shandong, Peoples R China
2.Shandong Univ, Student Counseling Ctr, Jinan, Shandong, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Cao, Cong,Cao, Lili,Chen, Jie. Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies[J]. JOURNAL OF YOUTH AND ADOLESCENCE,2019,48(4):655-667.
APA Cao, Cong,Cao, Lili,&Chen, Jie.(2019).Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies.JOURNAL OF YOUTH AND ADOLESCENCE,48(4),655-667.
MLA Cao, Cong,et al."Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies".JOURNAL OF YOUTH AND ADOLESCENCE 48.4(2019):655-667.
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