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Eltoprazine prevents levodopa-induced dyskinesias by reducing causal interactions for theta oscillations in the dorsolateral striatum and substantia nigra pars reticulate
Wang, Qiang1; Chen, Jiazhi1; Li, Min1; Lv, Siyuan1; Xie, Zhengyuan1; Li, Nanxiang1; Wang, Ning2; Wang, Jinyan2; Luo, Fei2; Zhang, Wangming1
First AuthorQiang Wang
2019-04-01
Source PublicationNEUROPHARMACOLOGY
Correspondent Emailwzhang@vip.126.com (w. zhang)
ISSN0028-3908
SubtypeArticle
Volume148Pages:1-10
Contribution Rank2
Abstract

Oscillatory activities within basal ganglia (BG) circuitry in L-DOPA induced dyskinesia (LID), a condition that occurs in patients with Parkinson disease (PD), are not well understood. The aims of this study were firstly to investigate oscillations in main BG input and output structures-the dorsolateral striatum (dStr) and substantia nigra pars reticulata (SNr), respectively- including the direction of oscillation information flow, and secondly to investigate the effects of 5-HT1A/B receptor agonism with eltoprazine on oscillatory activities and abnormal involuntary movements (AIMs) characteristic. To this end, we conducted local field potential (LFP) electrophysiology in the dStr and SNr of LID rats simultaneous with AIM scoring. The LFP data were submitted to power spectral density, coherence, and partial Granger causality analyses. AIM data were analyzed relative to simultaneous oscillatory activities, with and without eltoprazine. We obtained four major findings. 1) Theta band (5-8 Hz) oscillations were enhanced in the dStr and SNr of LID rats. 2) Theta power correlated with AIM scores in the 180-min period after the last LID-inducing L-DOPA injection, but not with daily summed AIM scores during LID development. 3) Oscillatory information flowed from the dStr to the SNr. 4) Chronic eltoprazine reduced BG theta activity in LID rats and normalized information flow directionality, relative to that in LID rats not given eltoprazine. These results indicate that dStr activity plays a determinative role in the causal interactions of theta oscillations and that serotonergic inhibition may suppress dyskinesia by reducing dStr-SNr theta activity and restoring theta network information flow.

KeywordParkinson disease L-DOPA induced dyskinesia Local field potential Serotonin Eltoprazine
DOI10.1016/j.neuropharm.2018.12.027
Indexed BySCI
Language英语
Funding ProjectGuangdong Provincial Clinical Medical Center for Neurosurgery[2013B020400005] ; National Natural Science Foundation of China[81771210]
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy
WOS SubjectNeurosciences ; Pharmacology & Pharmacy
WOS IDWOS:000463125000001
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordDOPA-INDUCED DYSKINESIA ; LOCAL-FIELD POTENTIALS ; GLUTAMIC-ACID DECARBOXYLASE ; SUBTHALAMIC NUCLEUS ; PARKINSONS-DISEASE ; RAT MODEL ; GLOBUS-PALLIDUS ; BASAL GANGLIA ; PEDUNCULOPONTINE NUCLEUS ; BETA OSCILLATIONS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28823
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Wangming
Affiliation1.Southern Med Univ, Guangdong Prov Key Lab Brain Funct Repair & Regen, Natl Key Clin Specialty,Zhujiang Hosp, Engn Technol Res Ctr,Educ Minist China, Guangzhou 510282, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qiang,Chen, Jiazhi,Li, Min,et al. Eltoprazine prevents levodopa-induced dyskinesias by reducing causal interactions for theta oscillations in the dorsolateral striatum and substantia nigra pars reticulate[J]. NEUROPHARMACOLOGY,2019,148:1-10.
APA Wang, Qiang.,Chen, Jiazhi.,Li, Min.,Lv, Siyuan.,Xie, Zhengyuan.,...&Zhang, Wangming.(2019).Eltoprazine prevents levodopa-induced dyskinesias by reducing causal interactions for theta oscillations in the dorsolateral striatum and substantia nigra pars reticulate.NEUROPHARMACOLOGY,148,1-10.
MLA Wang, Qiang,et al."Eltoprazine prevents levodopa-induced dyskinesias by reducing causal interactions for theta oscillations in the dorsolateral striatum and substantia nigra pars reticulate".NEUROPHARMACOLOGY 148(2019):1-10.
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