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Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review
Xu, Xiaolu1,2; Ren, Haitao1,2; Li, Libo1,2; Wang, Jing3; Fechner, Kai4; Guan, Hongzhi1,2
Corresponding AuthorGuan, Hongzhi(guanhz@263.net)
2019-05-15
Source PublicationJOURNAL OF NEUROIMMUNOLOGY
ISSN0165-5728
Volume330Pages:155-158
AbstractAnti-Homer-3 antibody associated cerebellar ataxia is a rare autoimmune cerebellar ataxia, which had been previously reported in 2 cases only. Here we present the third case where a middle-aged female experienced progressive cerebellar ataxia. A novel cerebellar ataxia antibody panel indicated sera of the patient was positive for anti-Homer-3 antibodies and established the diagnosis. Given steroids and long-term mycophenolate mofetil, the patient experienced partial improvement and remained stable in the follow-ups. Our report indicated immune-mediated causes should be considered in the context of 'idiopathic' cerebellar ataxia and immunotherapy could have therapeutic effects.
KeywordHomer-3 antibody Cerebellar ataxia Autoimmune
DOI10.1016/j.jneuroim.2019.01.002
Indexed BySCI ; SCI
Language英语
WOS Research AreaImmunology ; Neurosciences & Neurology
WOS SubjectImmunology ; Neurosciences
WOS IDWOS:000465057100027
PublisherELSEVIER SCIENCE BV
WOS KeywordAUTOIMMUNITY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28935
Collection中国科学院心理健康重点实验室
Corresponding AuthorGuan, Hongzhi
Affiliation1.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, 1 Shuaifuyuan,Wangfujing St, Beijing 100730, Peoples R China
2.Chinese Acad Med Sci, 1 Shuaifuyuan,Wangfujing St, Beijing 100730, Peoples R China
3.Chinese Acad Sci, Dept Psychol, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Euroimmun AG, Inst Expt Immunol, Lubeck, Germany
Recommended Citation
GB/T 7714
Xu, Xiaolu,Ren, Haitao,Li, Libo,et al. Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review[J]. JOURNAL OF NEUROIMMUNOLOGY,2019,330:155-158.
APA Xu, Xiaolu,Ren, Haitao,Li, Libo,Wang, Jing,Fechner, Kai,&Guan, Hongzhi.(2019).Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review.JOURNAL OF NEUROIMMUNOLOGY,330,155-158.
MLA Xu, Xiaolu,et al."Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review".JOURNAL OF NEUROIMMUNOLOGY 330(2019):155-158.
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