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Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review
Xu, Xiaolu1; Ren, Haitao1; Li, Libo1; Wang, Jing2; Fechner, Kai3; Guan, Hongzhi1
First AuthorXu, Xiaolu
2019-05-15
Source PublicationJOURNAL OF NEUROIMMUNOLOGY
Correspondent Emailh. guan(guanhz@263.net)
ISSN0165-5728
Subtypearticle
Volume330Pages:155-158
Contribution Rank2
Abstract

Anti-Homer-3 antibody associated cerebellar ataxia is a rare autoimmune cerebellar ataxia, which had been previously reported in 2 cases only. Here we present the third case where a middle-aged female experienced progressive cerebellar ataxia. A novel cerebellar ataxia antibody panel indicated sera of the patient was positive for anti-Homer-3 antibodies and established the diagnosis. Given steroids and long-term mycophenolate mofetil, the patient experienced partial improvement and remained stable in the follow-ups. Our report indicated immune-mediated causes should be considered in the context of 'idiopathic' cerebellar ataxia and immunotherapy could have therapeutic effects.

KeywordHomer-3 antibody Cerebellar ataxia Autoimmune
DOI10.1016/j.jneuroim.2019.01.002
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Neurosciences & Neurology
WOS SubjectImmunology ; Neurosciences
WOS IDWOS:000465057100027
PublisherELSEVIER SCIENCE BV
WOS KeywordAUTOIMMUNITY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28935
Collection中国科学院心理健康重点实验室
Corresponding AuthorGuan, Hongzhi
Affiliation1.Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
2.CAS Key Laboratory of Mental Health, Institute of Psychology, Department of Psychology, Chinese Academy of Sciences, Beijing, China
3.Institute of Experimental Immunology, Affiliated to Euroimmun AG, Lübeck, Germany
Recommended Citation
GB/T 7714
Xu, Xiaolu,Ren, Haitao,Li, Libo,et al. Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review[J]. JOURNAL OF NEUROIMMUNOLOGY,2019,330:155-158.
APA Xu, Xiaolu,Ren, Haitao,Li, Libo,Wang, Jing,Fechner, Kai,&Guan, Hongzhi.(2019).Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review.JOURNAL OF NEUROIMMUNOLOGY,330,155-158.
MLA Xu, Xiaolu,et al."Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review".JOURNAL OF NEUROIMMUNOLOGY 330(2019):155-158.
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