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Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review
Xu, Xiaolu1; Ren, Haitao1; Li, Libo1; Wang, Jing2; Fechner, Kai3; Guan, Hongzhi1
第一作者Xu, Xiaolu
通讯作者邮箱h. guan(guanhz@263.net)
心理所单位排序2
摘要

Anti-Homer-3 antibody associated cerebellar ataxia is a rare autoimmune cerebellar ataxia, which had been previously reported in 2 cases only. Here we present the third case where a middle-aged female experienced progressive cerebellar ataxia. A novel cerebellar ataxia antibody panel indicated sera of the patient was positive for anti-Homer-3 antibodies and established the diagnosis. Given steroids and long-term mycophenolate mofetil, the patient experienced partial improvement and remained stable in the follow-ups. Our report indicated immune-mediated causes should be considered in the context of 'idiopathic' cerebellar ataxia and immunotherapy could have therapeutic effects.

关键词Homer-3 antibody Cerebellar ataxia Autoimmune
2019-05-15
语种英语
DOI10.1016/j.jneuroim.2019.01.002
发表期刊JOURNAL OF NEUROIMMUNOLOGY
ISSN0165-5728
卷号330页码:155-158
期刊论文类型article
收录类别SCI
出版者ELSEVIER SCIENCE BV
WOS关键词AUTOIMMUNITY
WOS研究方向Immunology ; Neurosciences & Neurology
WOS类目Immunology ; Neurosciences
WOS记录号WOS:000465057100027
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://ir.psych.ac.cn/handle/311026/28935
专题中国科学院心理健康重点实验室
通讯作者Guan, Hongzhi
作者单位1.Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
2.CAS Key Laboratory of Mental Health, Institute of Psychology, Department of Psychology, Chinese Academy of Sciences, Beijing, China
3.Institute of Experimental Immunology, Affiliated to Euroimmun AG, Lübeck, Germany
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GB/T 7714
Xu, Xiaolu,Ren, Haitao,Li, Libo,et al. Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review[J]. JOURNAL OF NEUROIMMUNOLOGY,2019,330:155-158.
APA Xu, Xiaolu,Ren, Haitao,Li, Libo,Wang, Jing,Fechner, Kai,&Guan, Hongzhi.(2019).Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review.JOURNAL OF NEUROIMMUNOLOGY,330,155-158.
MLA Xu, Xiaolu,et al."Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review".JOURNAL OF NEUROIMMUNOLOGY 330(2019):155-158.
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