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Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer's Disease
Wang, Ziqi1,2; Qiao, Kaini3,4,5; Chen, Guanqun1; Sui, Danyang3,4,5; Dong, Hao-Ming3,4,5; Wang, Yin-Shan5; Li, Hui-Jie3,4,5; Lu, Jie6,7,8; Zuo, Xi-Nian3,4,5; Han, Ying1,9,10,11
First AuthorWang, Ziqi
2019-04-24
Source PublicationFRONTIERS IN NEUROINFORMATICS
Correspondent Emailying han(hanying@xwh.ccmu.edu.cn)
ISSN1662-5196
Subtypearticle
Volume13Pages:11
Contribution Rank3
Abstract

The abnormality occurs at molecular, cellular as well as network levels in patients with Alzheimer's disease (AD) prior to diagnosis. Most previous connectivity studies were conducted at 1 out of 3 (local, meso and global) scales in subjects covering only part of the entire AD spectrum (subjective cognitive decline, SCD; amnestic mild cognitive impairment, aMCI; and then fully manifest AD). Data interpretation within the framework of disease progression is therefore difficult. The current study included 3 age- and sex-matched cohorts: SCD (n = 32), aMCI (n = 37) and fully-established AD (n = 30). A group of healthy elderly subjects (n = 40) were included as a normal control (NC). Network connectivity was examined at the local (degree centrality), meso [subgraph centrality (SC)], and global (eigenvector and page-rank centralities) levels. As compared to NC, SCD subjects had isolated decrease of SC in primary (somatomotor and visual) networks. aMCI subjects had decreased centralities at all three scales in associative (frontoparietal control, dorsal attention, limbic and default) networks. AD subjects had increased centrality at the global scale in all seven networks. There was a positive association between Montreal Cognitive Assessment (MoCA) scores and DC in the frontoparietal control network in SCD, a negative relationship between Mini-Mental State Examination (MMSE) scores and EC in the somatomotor network in AD. These findings suggest that the primary network is impaired as early as in SCD. Impairment in the associative network also starts at the local level at this stage and may contribute to the cognitive decline. As associative network impairment extends from local to meso and global scales in aMCI, compensatory mechanisms in the primary network are activated.

Keywordnetwork neuroscience brain connectivity centrality Alzheimer's disease subjective cognitive decline amnestic mild cognitive impairment
DOI10.3389/fninf.2019.00026
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Nature Science Foundation ; Beijing Municipal Commission of Health and Family Planning
Funding ProjectNational Key Research and Development Program of China[2016YFC1306300] ; National Key Research and Development Program of China[2016YFC0103000] ; National Natural Science Foundation of China[61633018] ; National Natural Science Foundation of China[81801052] ; National Natural Science Foundation of China[81522021] ; National Natural Science Foundation of China[81430037] ; National Natural Science Foundation of China[81471731] ; Beijing Nature Science Foundation[7161009] ; Beijing Municipal Commission of Health and Family Planning[PXM2019_026283_000002]
WOS Research AreaMathematical & Computational Biology ; Neurosciences & Neurology
WOS SubjectMathematical & Computational Biology ; Neurosciences
WOS IDWOS:000465701900001
PublisherFRONTIERS MEDIA SA
WOS KeywordVENTRAL ATTENTION SYSTEMS ; RESTING-STATE FMRI ; EIGENVECTOR CENTRALITY ; BRAIN NETWORK ; DEMENTIA ; DORSAL ; MCI ; DEGENERATION ; ORGANIZATION ; INDIVIDUALS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28947
Collection中国科学院行为科学重点实验室
Corresponding AuthorHan, Ying
Affiliation1.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
2.Chengdu Fifth Peoples Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China
3.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
4.Inst Psychol, Res Ctr Lifespan Dev Mind & Brain CLIMB, Beijing, Peoples R China
5.Univ Chinese Acad Sci, CAS, Dept Psychol, Beijing, Peoples R China
6.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
7.Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, Beijing, Peoples R China
8.Beijing Key Lab Magnet Resonance Imaging & Brain, Beijing, Peoples R China
9.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China
10.Beijing Inst Geriatr, Beijing, Peoples R China
11.Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Ziqi,Qiao, Kaini,Chen, Guanqun,et al. Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer's Disease[J]. FRONTIERS IN NEUROINFORMATICS,2019,13:11.
APA Wang, Ziqi.,Qiao, Kaini.,Chen, Guanqun.,Sui, Danyang.,Dong, Hao-Ming.,...&Han, Ying.(2019).Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer's Disease.FRONTIERS IN NEUROINFORMATICS,13,11.
MLA Wang, Ziqi,et al."Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer's Disease".FRONTIERS IN NEUROINFORMATICS 13(2019):11.
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