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The interaction between positive schizotypy and high sensitivity C-reactive protein on response inhibition in female individuals
Gong Jingbo1; Wang Ya2; Liu Jianbo3; Fu Xiaogao1; Cheung, Eric F. C.4; Chan, Raymond C. K.2,5
First AuthorGong Jingbo
2019-04-01
Source PublicationPSYCHIATRY RESEARCH
Correspondent Emailr.c.k. chan(rckchan@psych.ac.cn)
ISSN0165-1781
Subtypearticle
Volume274Pages:365-371
Contribution Rank2
Abstract

This study aimed to measure the associations between high sensitivity C-reactive protein (hsCRP), childhood maltreatment (CM), schizotypy and response inhibition, and to explore the interactions between hsCRP, CM and schizotypy on response inhibition. Two hundred and fourteen participants completed the Stop-Signal Task (SST), the Schizotypy Personality Questionnaire (SPQ) and the Childhood Trauma Questionnaire-Short Form (CTQ), which measured response inhibition, schizotypy and history of CM respectively. The level of hsCRP was also measured. The high schizotypy group (n = 114) had higher scores on SPQ and CTQ, higher hsCRP levels and longer SST reaction times (SSRTs) than the low schizotypy group (n = 100). In female participants, SSRT had a positive correlation with the SPQ positive factor and the disorganized SPQ factor and a positive correlation with physical neglect. HsCRP was positively correlated with the SPQ negative factor and positive SPQ factor. In male participants, SSRT was negatively correlated with emotional neglect and physical neglect. The majority of correlations between CTQ and SPQ variables were significant in both female and male participants. In female participants, hsCRP significantly predicted SSRT, and hsCRP significantly interacted with positive schizotypy in predicting SSRT.

KeywordSchizotypy Childhood maltreatment High sensitive C-reactive protein Response inhibition
DOI10.1016/j.psychres.2019.02.064
Indexed BySCI
Language英语
Funding OrganizationChina Postdoctoral Science Foundation ; Hunan Natural Science Foundation ; Hunan Education Department Excellent Youth Fund ; National Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; CAS Key Laboratory of Mental Health, the Institute of Psychology
Funding ProjectChina Postdoctoral Science Foundation[2016M591278] ; Hunan Natural Science Foundation[2017JJ3240] ; Hunan Education Department Excellent Youth Fund[16B201] ; National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; CAS Key Laboratory of Mental Health, the Institute of Psychology
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000465059300048
PublisherELSEVIER IRELAND LTD
WOS KeywordCELLULAR IMMUNE-RESPONSES ; FORMAL THOUGHT-DISORDER ; CHILDHOOD SEXUAL-ABUSE ; BODY-MASS INDEX ; COGNITIVE IMPAIRMENT ; SCHIZOPHRENIA-PATIENTS ; INFLAMMATORY MARKERS ; LATENT INHIBITION ; WORKING-MEMORY ; TRAUMA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/28950
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Hunan Univ Chinese Med, Dept Appl Psychol, Changsha 410208, Hunan, Peoples R China
2.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
3.Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
4.Castle Peak Hosp, Hong Kong, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Gong Jingbo,Wang Ya,Liu Jianbo,et al. The interaction between positive schizotypy and high sensitivity C-reactive protein on response inhibition in female individuals[J]. PSYCHIATRY RESEARCH,2019,274:365-371.
APA Gong Jingbo,Wang Ya,Liu Jianbo,Fu Xiaogao,Cheung, Eric F. C.,&Chan, Raymond C. K..(2019).The interaction between positive schizotypy and high sensitivity C-reactive protein on response inhibition in female individuals.PSYCHIATRY RESEARCH,274,365-371.
MLA Gong Jingbo,et al."The interaction between positive schizotypy and high sensitivity C-reactive protein on response inhibition in female individuals".PSYCHIATRY RESEARCH 274(2019):365-371.
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