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Reduced default mode network functional connectivity in patients with recurrent major depressive disorder
Yan, Chao-Gan1,2,3,4,5; Chen, Xiao1,2; Li, Le1,2; Castellanos, Francisco Xavier5,6; Bai, Tong-Jian7; Bo, Qi-Jing8; Cao, Jun9; Chen, Guan-Mao10; Chen, Ning-Xuan1,2; Chen, Wei11; Cheng, Chang12; Cheng, Yu-Qi13; Cui, Xi-Long12; Duan, Jia14; Fang, Yi-Ru15; Gong, Qi-Yong16,17; Guo, Wen-Bin12; Hou, Zheng-Hua18; Hu, Lan9; Kuang, Li9; Li, Feng8; Li, Kai-Ming16; Li, Tao19; Liu, Yan-Song20; Liu, Zhe-Ning12; Long, Yi-Cheng12; Luo, Qing-Hua9; Meng, Hua-Qing9; Peng, Dai-Hui15; Qiu, Hai-Tang9; Qiu, Jiang21; Shen, Yue-Di22; Shi, Yu-Shu23; Wang, Chuan-Yue8; Wang, Fei14; Wang, Kai7; Wang, Li24,25; Wang, Xiang12; Wang, Ying10; Wu, Xiao-Ping26; Wu, Xin-Ran21; Xie, Chun-Ming27; Xie, Guang-Rong12; Xie, Hai-Yan28; Xie, Peng29,30,31; Xu, Xiu-Feng13; Yang, Hong23; Yang, Jian32; Yao, Jia-Shu11; Yao, Shu-Qiao12; Yin, Ying-Ying18; Yuan, Yong-Gui18; Zhang, Ai-Xia32; Zhang, Hong26; Zhang, Ke-Rang33; Zhang, Lei1,2; Zhang, Zhi-Jun27; Zhou, Ru-Bai15; Zhou, Yi-Ting19; Zhu, Jun-Juan15; Zou, Chao-Jie13; Si, Tian-Mei24,25; Zuo, Xi-Nian1,2,3,4; Zhao, Jing-Ping12; Zang, Yu-Feng34,35
Corresponding AuthorYan, Chao-Gan(ycg.yan@gmail.com) ; Zhao, Jing-Ping(zhaojingping@csu.edu.cn) ; Zang, Yu-Feng(zangyf@hznu.edu.cn)
2019-04-30
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume116Issue:18Pages:9078-9083
AbstractMajor depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups in China established the REST-meta-MDD Consortium by contributing R-fMRI data from 1,300 patients with MDD and 1,128 normal controls (NCs). Data were preprocessed locally with a standardized protocol before aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to be increased in MDD. Instead, we found decreased DMN FC when we compared 848 patients with MDD to 794 NCs from 17 sites after data exclusion. We found FC reduction only in recurrent MDD, not in first-episode drug-naive MDD. Decreased DMN FC was associated with medication usage but not with MDD duration. DMN FC was also positively related to symptom severity but only in recurrent MDD. Exploratory analyses also revealed alterations in FC of visual, sensory-motor, and dorsal attention networks in MDD. We confirmed the key role of DMN in MDD but found reduced rather than increased FC within the DMN. Future studies should test whether decreased DMN FC mediates response to treatment. All R-fMRI indices of data contributed by the REST-meta-MDD consortium are being shared publicly via the R-fMRI Maps Project.
Keyworddefault mode network functional connectivity major depressive disorder resting-state fMRI REST-meta-MDD
DOI10.1073/pnas.1900390116
Indexed BySCI ; SCI
Language英语
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; Hundred Talents Program ; 13th Five-Year Informatization Plan of the Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Department of Science and Technology, Zhejiang Province ; National Basic Research (973) Program
Funding ProjectNational Key R&D Program of China[2017YFC1309902] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; National Natural Science Foundation of China[81471740] ; National Natural Science Foundation of China[81621003] ; National Natural Science Foundation of China[81371488] ; Hundred Talents Program ; 13th Five-Year Informatization Plan of the Chinese Academy of Sciences[XXH13505] ; Beijing Municipal Science & Technology Commission[Z161100000216152] ; Beijing Municipal Science & Technology Commission[Z171100000117016] ; Beijing Municipal Science & Technology Commission[Z161100002616023] ; Beijing Municipal Science & Technology Commission[Z171100000117012] ; Department of Science and Technology, Zhejiang Province[2015C03037] ; National Basic Research (973) Program[2015CB351702]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000466446500064
PublisherNATL ACAD SCIENCES
WOS KeywordCINGULATE CORTEX ; METAANALYSIS ; FAILURE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29010
Collection中国科学院行为科学重点实验室
Corresponding AuthorYan, Chao-Gan; Zhao, Jing-Ping; Zang, Yu-Feng
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Res Ctr Lifespan Dev Mind & Brain, Beijing 100101, Peoples R China
5.NYU, Sch Med, Dept Child & Adolescent Psychiat, New York, NY 10016 USA
6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
7.Anhui Med Univ, Hefei 230022, Anhui, Peoples R China
8.Capital Med Univ, Beijing Anding Hosp, Beijing 100054, Peoples R China
9.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China
10.Jinan Univ, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China
11.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Psychiat, Hangzhou 310016, Zhejiang, Peoples R China
12.Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China
13.Kunming Med Univ, Affiliated Hosp 1, Kunming 650032, Yunnan, Peoples R China
14.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang 110001, Liaoning, Peoples R China
15.Shanghai Jiao Tong Univ, Sch Med, Dept Psychiat, Shanghai 200240, Peoples R China
16.Sichuan Univ, West China Hosp, Huaxi MR Res Ctr, Dept Radiol, Chengdu 610041, Sichuan, Peoples R China
17.Sichuan Univ, West China Hosp, Chinese Acad Med Sci, Psychoradiol Res Unit, Chengdu 610041, Sichuan, Peoples R China
18.Southeast Univ, Sch Med, Zhongda Hosp, Dept Psychosomat & Psychiat, Nanjing 210096, Jiangsu, Peoples R China
19.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610041, Sichuan, Peoples R China
20.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Dept Clin Psychol, Suzhou 215137, Jiangsu, Peoples R China
21.Southwest Univ, Fac Psychol, Chongqing 400716, Peoples R China
22.Hangzhou Normal Univ, Sch Med, Affiliated Hosp, Dept Diagnost, Hangzhou 311121, Zhejiang, Peoples R China
23.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Radiol, Hangzhou 310058, Zhejiang, Peoples R China
24.Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
25.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
26.Xian Cent Hosp, Xian 710003, Shaanxi, Peoples R China
27.Southeast Univ, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing 210009, Jiangsu, Peoples R China
28.Zhejiang Univ, Coll Med, Affiliated Hosp 4, Dept Psychiat, Hangzhou 310058, Zhejiang, Peoples R China
29.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China
30.Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China
31.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China
32.Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China
33.Shanxi Med Univ, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China
34.Hangzhou Normal Univ, Inst Psychol Sci, Ctr Cognit & Brain Disorders, Hangzhou 311121, Zhejiang, Peoples R China
35.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 311121, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Yan, Chao-Gan,Chen, Xiao,Li, Le,et al. Reduced default mode network functional connectivity in patients with recurrent major depressive disorder[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(18):9078-9083.
APA Yan, Chao-Gan.,Chen, Xiao.,Li, Le.,Castellanos, Francisco Xavier.,Bai, Tong-Jian.,...&Zang, Yu-Feng.(2019).Reduced default mode network functional connectivity in patients with recurrent major depressive disorder.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(18),9078-9083.
MLA Yan, Chao-Gan,et al."Reduced default mode network functional connectivity in patients with recurrent major depressive disorder".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.18(2019):9078-9083.
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