PSYCH OpenIR  > 健康与遗传心理学研究室
The TNF-Alpha Gene-1031T > C Polymorphism Is Associated With Onset Age but Not With Risk of Schizophrenia in a Chinese Population
Xiu, Meihong1; Zhang, Guangya2; Chen, Nan1; Chen, Song1; Tan, Yunlong1; Yin, Guangzhou2; Man, Lijuan2; Ning, Yuping3; Huang, Xingbing3; Teixeira, Antonio L.4; Soares, Jair C.4; Du, Xiangdong2; Lang, Xiaoe5; Zhang, Xiang Yang4,6
第一作者Meihong Xiu
通讯作者邮箱langxiaoe@yeah.net ; zhangxy@psych.ac.cn
摘要

Objective: Evidence has shown the importance of tumor necrosis factor alpha (TNF-alpha) in the pathophysiological feature in schizophrenia patients. This study aims to determine the impact of a single-nucleotide polymorphism (SNP) in the TNF-alpha gene promoter on the susceptibility, onset age, and cognitive function of schizophrenia. Method: The SNP -1031T>C in the TNF-alpha gene was genotyped in 905 patients and 571 healthy controls. The Positive and Negative Syndrome Scale (PANSS) was used to assess the schizophrenia symptoms and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognitive function. Results: There was no significant difference in allele or genotype distribution of the SNP -1031T>C between patients and controls (p = .85, p = .98). This polymorphism had no significant genotypic effect on the symptomatology assessed by the PANSS. Interestingly, this polymorphism was significantly correlated with onset age in schizophrenia patients (p = .004). We found an earlier onset age in patients with the TT genotype compared to those with the CT and CC genotypes (both p < .05). Moreover, there were significant genotypic effects on the immediate memory index, visuospatial/constructional index, and RBANS total score (all p < 0.05) in the patient group. Conclusions: Our results suggest that the SNP -1031T>C of the TNF-alpha gene may not be associated with susceptibility to schizophrenia but possibly acts as a modulator for its onset age as well as for cognitive deficits. General Scientific Summary The TNF alpha-1031T/C variant is not associated with schizophrenia or its clinical symptoms but with onset age and some cognitive deficits of schizophrenia.

关键词schizophrenia tumor necrosis factor genotype association immune onset age
2019-05-01
语种英语
DOI10.1037/neu0000535
发表期刊NEUROPSYCHOLOGY
ISSN0894-4105
卷号33期号:4页码:482-489
期刊论文类型article
收录类别SCI
资助项目Suzhou Key Disciplines[Szxk201515] ; Key Diagnosis and treatment Program of Suzhou[LCZX201515] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Clinical Medical Expert Team Introduced Project[SZYJTD201715]
出版者AMER PSYCHOLOGICAL ASSOC
WOS关键词NECROSIS-FACTOR-ALPHA ; SERUM-LEVELS ; PROMOTER POLYMORPHISMS ; CYTOKINE ALTERATIONS ; GENE POLYMORPHISM ; BIPOLAR DISORDER ; NO ASSOCIATION ; BRAIN ; INTERLEUKIN-1-BETA ; PSYCHOPATHOLOGY
WOS研究方向Psychology ; Neurosciences & Neurology
WOS类目Psychology, Clinical ; Neurosciences ; Psychology
WOS记录号WOS:000466110100004
资助机构Suzhou Key Disciplines ; Key Diagnosis and treatment Program of Suzhou ; Suzhou Key Medical Center for Psychiatric Diseases ; Suzhou Clinical Medical Expert Team Introduced Project
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/29025
专题健康与遗传心理学研究室
通讯作者Lang, Xiaoe; Zhang, Xiang Yang
作者单位1.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
2.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China
3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Psychiat & Behav Sci, Houston, TX USA
5.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, 85 Jiefang Southern Rd, Taiyuan 030001, Shanxi, Peoples R China
6.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
通讯作者单位中国科学院心理研究所
推荐引用方式
GB/T 7714
Xiu, Meihong,Zhang, Guangya,Chen, Nan,et al. The TNF-Alpha Gene-1031T > C Polymorphism Is Associated With Onset Age but Not With Risk of Schizophrenia in a Chinese Population[J]. NEUROPSYCHOLOGY,2019,33(4):482-489.
APA Xiu, Meihong.,Zhang, Guangya.,Chen, Nan.,Chen, Song.,Tan, Yunlong.,...&Zhang, Xiang Yang.(2019).The TNF-Alpha Gene-1031T > C Polymorphism Is Associated With Onset Age but Not With Risk of Schizophrenia in a Chinese Population.NEUROPSYCHOLOGY,33(4),482-489.
MLA Xiu, Meihong,et al."The TNF-Alpha Gene-1031T > C Polymorphism Is Associated With Onset Age but Not With Risk of Schizophrenia in a Chinese Population".NEUROPSYCHOLOGY 33.4(2019):482-489.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
The TNF-alpha gene -(139KB)期刊论文作者接受稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xiu, Meihong]的文章
[Zhang, Guangya]的文章
[Chen, Nan]的文章
百度学术
百度学术中相似的文章
[Xiu, Meihong]的文章
[Zhang, Guangya]的文章
[Chen, Nan]的文章
必应学术
必应学术中相似的文章
[Xiu, Meihong]的文章
[Zhang, Guangya]的文章
[Chen, Nan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。