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The TNF-Alpha Gene-1031T > C Polymorphism Is Associated With Onset Age but Not With Risk of Schizophrenia in a Chinese Population
Xiu, Meihong1; Zhang, Guangya2; Chen, Nan1; Chen, Song1; Tan, Yunlong1; Yin, Guangzhou2; Man, Lijuan2; Ning, Yuping3; Huang, Xingbing3; Teixeira, Antonio L.4; Soares, Jair C.4; Du, Xiangdong2; Lang, Xiaoe5; Zhang, Xiang Yang4,6
Corresponding AuthorLang, Xiaoe(langxiaoe@yeah.net) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
2019-05-01
Source PublicationNEUROPSYCHOLOGY
ISSN0894-4105
Volume33Issue:4Pages:482-489
AbstractObjective: Evidence has shown the importance of tumor necrosis factor alpha (TNF-alpha) in the pathophysiological feature in schizophrenia patients. This study aims to determine the impact of a single-nucleotide polymorphism (SNP) in the TNF-alpha gene promoter on the susceptibility, onset age, and cognitive function of schizophrenia. Method: The SNP -1031T>C in the TNF-alpha gene was genotyped in 905 patients and 571 healthy controls. The Positive and Negative Syndrome Scale (PANSS) was used to assess the schizophrenia symptoms and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognitive function. Results: There was no significant difference in allele or genotype distribution of the SNP -1031T>C between patients and controls (p = .85, p = .98). This polymorphism had no significant genotypic effect on the symptomatology assessed by the PANSS. Interestingly, this polymorphism was significantly correlated with onset age in schizophrenia patients (p = .004). We found an earlier onset age in patients with the TT genotype compared to those with the CT and CC genotypes (both p < .05). Moreover, there were significant genotypic effects on the immediate memory index, visuospatial/constructional index, and RBANS total score (all p < 0.05) in the patient group. Conclusions: Our results suggest that the SNP -1031T>C of the TNF-alpha gene may not be associated with susceptibility to schizophrenia but possibly acts as a modulator for its onset age as well as for cognitive deficits. General Scientific Summary The TNF alpha-1031T/C variant is not associated with schizophrenia or its clinical symptoms but with onset age and some cognitive deficits of schizophrenia.
Keywordschizophrenia tumor necrosis factor genotype association immune onset age
DOI10.1037/neu0000535
Indexed BySCI ; SCI
Language英语
Funding OrganizationSuzhou Key Disciplines ; Key Diagnosis and treatment Program of Suzhou ; Suzhou Key Medical Center for Psychiatric Diseases ; Suzhou Clinical Medical Expert Team Introduced Project ; CAS Pioneer Hundred Talents Program
Funding ProjectSuzhou Key Disciplines[Szxk201515] ; Key Diagnosis and treatment Program of Suzhou[LCZX201515] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Clinical Medical Expert Team Introduced Project[SZYJTD201715] ; CAS Pioneer Hundred Talents Program
WOS Research AreaPsychology ; Neurosciences & Neurology
WOS SubjectPsychology, Clinical ; Neurosciences ; Psychology
WOS IDWOS:000466110100004
PublisherAMER PSYCHOLOGICAL ASSOC
WOS KeywordNECROSIS-FACTOR-ALPHA ; SERUM-LEVELS ; PROMOTER POLYMORPHISMS ; CYTOKINE ALTERATIONS ; GENE POLYMORPHISM ; BIPOLAR DISORDER ; NO ASSOCIATION ; BRAIN ; INTERLEUKIN-1-BETA ; PSYCHOPATHOLOGY
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29025
Collection健康与遗传心理学研究室
Corresponding AuthorLang, Xiaoe; Zhang, Xiang Yang
Affiliation1.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
2.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China
3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Psychiat & Behav Sci, Houston, TX USA
5.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, 85 Jiefang Southern Rd, Taiyuan 030001, Shanxi, Peoples R China
6.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Xiu, Meihong,Zhang, Guangya,Chen, Nan,et al. The TNF-Alpha Gene-1031T > C Polymorphism Is Associated With Onset Age but Not With Risk of Schizophrenia in a Chinese Population[J]. NEUROPSYCHOLOGY,2019,33(4):482-489.
APA Xiu, Meihong.,Zhang, Guangya.,Chen, Nan.,Chen, Song.,Tan, Yunlong.,...&Zhang, Xiang Yang.(2019).The TNF-Alpha Gene-1031T > C Polymorphism Is Associated With Onset Age but Not With Risk of Schizophrenia in a Chinese Population.NEUROPSYCHOLOGY,33(4),482-489.
MLA Xiu, Meihong,et al."The TNF-Alpha Gene-1031T > C Polymorphism Is Associated With Onset Age but Not With Risk of Schizophrenia in a Chinese Population".NEUROPSYCHOLOGY 33.4(2019):482-489.
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