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Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis
Song, Sensen1,2; Zilverstand, Anna3; Gui, Wenjun4,6; Li, Hui-jie5,6; Zhou, Xiaolin1,2,7,8
Corresponding AuthorZhou, Xiaolin(xz104@pku.edu.cn)
2019-05-01
Source PublicationBRAIN STIMULATION
ISSN1935-861X
Volume12Issue:3Pages:606-618
AbstractBackground: Brain stimulation interventions are increasingly used to reduce craving and consumption in individuals with drug addiction or excessive eating behavior. However, the efficacy of these novel treatments and whether effect sizes are affected by the length of the intervention has not been comprehensively evaluated. Objective: A meta-analytical approach was employed to evaluate the effectiveness of non-invasive excitatory brain stimulation [transcranial Direct Current Stimulation (tDCS) and high-frequency repetitive Transcranial Magnetic Stimulation (rTMS)] targeted at dorsolateral prefrontal cortex (dlPFC) for reducing craving and consumption levels in drug and eating addiction, including both single- and multi-session protocols. Methods: After a comprehensive literature search, 48 peer-reviewed studies (1095 participants in total) were included in the current meta-analysis. We computed Hedge's g as a conservative measure for evaluating effect sizes. Results: Random effects analyses revealed a small effect of neuromodulation interventions on craving and a medium effect on consumption, favoring active over sham stimulation. These effects did not differ across the different populations investigated (alcohol, nicotine, illicit drugs, eating addictions) or by the used technique (rTMS/tDCS, left/right hemisphere). Multi-session protocols showed a larger effect size for reducing craving and consumption than single-session protocols, with a positive linear association between the number of sessions or administered pulses and craving reduction, indicating a dose-response effect. Conclusions: Our results provide compelling evidence that novel non-invasive brain stimulation targeted at dlPFC reduces craving and consumption levels (providing the first meta-analytical evidence for the latter effect in drug addiction), with larger effects in multi-session as compared to single-session interventions. (C) 2018 Elsevier Inc. All rights reserved.
KeywordBrain stimulation tDCS rTMS dlPFC Addiction Eating disorders
DOI10.1016/j.brs.2018.12.975
Indexed BySCI ; SCI
Language英语
Funding OrganizationNational Basic Research Program of China ; National Natural Science Foundation of China
Funding ProjectNational Basic Research Program of China[2015CB856400] ; National Natural Science Foundation of China[31630034]
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000465395800002
PublisherELSEVIER SCIENCE INC
WOS KeywordTRANSCRANIAL MAGNETIC STIMULATION ; DORSOLATERAL PREFRONTAL CORTEX ; ALCOHOL-DEPENDENT PATIENTS ; SUBSTANCE USE DISORDERS ; FOOD CRAVINGS ; CORTICAL STIMULATION ; SMOKING ; RTMS ; METHAMPHETAMINE ; MODULATION
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29046
Collection中国科学院心理健康重点实验室
中国科学院行为科学重点实验室
Corresponding AuthorZhou, Xiaolin
Affiliation1.Tongji Univ, Sch Humanities, Shanghai 200092, Peoples R China
2.Peking Univ, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
3.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55414 USA
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
7.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China
8.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Song, Sensen,Zilverstand, Anna,Gui, Wenjun,et al. Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis[J]. BRAIN STIMULATION,2019,12(3):606-618.
APA Song, Sensen,Zilverstand, Anna,Gui, Wenjun,Li, Hui-jie,&Zhou, Xiaolin.(2019).Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis.BRAIN STIMULATION,12(3),606-618.
MLA Song, Sensen,et al."Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis".BRAIN STIMULATION 12.3(2019):606-618.
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