DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats | |
Zhang, Jianjun![]() ![]() ![]() ![]() | |
第一作者 | Zhang, Jianjun ; Jiang, Fengze |
心理所单位排序 | 1 |
摘要 | Drug-reinforced excessive operant responding is one fundamental feature of long-lasting addiction-like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug-specific (not natural rewards) operant behavior are not entirely clear. In this study, we demonstrate a key role for one of the de novo DNA methyltransferase, DNMT3a, in the acquisition of morphine self-administration (SA) in rats. The expression of DNMT3a in the hippocampal CA1 region but not in the nucleus accumbens shell was significantly up-regulated after 1- and 7-day morphine SA (0.3 mg/kg/infusion) but not after the yoked morphine injection. On the other hand, saccharin SA did not affect the expression of DNMT3a or DNMT3b. DNMT inhibitor 5-aza-2-deoxycytidine (5-aza) microinjected into the hippocampal CA1 significantly attenuated the acquisition of morphine SA. Knockdown of DNMT3a also impaired the ability to acquire the morphine SA. Overall, these findings suggest that DNMT3a in the hippocampus plays an important role in the acquisition of morphine SA and may be a valid target to prevent the development of morphine addiction. |
关键词 | acquisition DNMT3a hippocampal CA1 morphine self-administration |
2019 | |
DOI | 10.1111/adb.12730 |
发表期刊 | Addiction Biology
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ISSN | 1355-6215 |
卷号 | 25期号:2页码:1–12 |
收录类别 | SCI |
出版者 | WILEY |
WOS关键词 | NUCLEUS-ACCUMBENS SHELL ; INDUCED PLACE PREFERENCE ; DNA METHYLATION ; EPIGENETIC MECHANISMS ; NATURAL REWARDS ; DRUG-ADDICTION ; COCAINE ; EXPRESSION ; DOPAMINE ; HEROIN |
WOS研究方向 | Biochemistry & Molecular Biology ; Substance Abuse |
WOS类目 | Biochemistry & Molecular Biology ; Substance Abuse |
WOS记录号 | WOS:000534069700013 |
WOS分区 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/29081 |
专题 | 健康与遗传心理学研究室 |
通讯作者 | Sui, Nan |
作者单位 | 1.CAS Key Laboratory of Mental Health, Institute of Psychology 2.Department of Psychology, University of Chinese Academy of Sciences |
推荐引用方式 GB/T 7714 | Zhang, Jianjun,Jiang, Fengze,Zheng, Wei,et al. DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats[J]. Addiction Biology,2019,25(2):1–12. |
APA | Zhang, Jianjun.,Jiang, Fengze.,Zheng, Wei.,Duan, Ying.,Jin, Shubo.,...&Sui, Nan.(2019).DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats.Addiction Biology,25(2),1–12. |
MLA | Zhang, Jianjun,et al."DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats".Addiction Biology 25.2(2019):1–12. |
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2019 AB DNMT3a in th(915KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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