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DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats
Zhang, Jianjun; Jiang, Fengze; Zheng, Wei; Duan, Ying; Jin, Shubo; Shen, Fang; Liang, Jing; Li, Ming; Sui, Nan
第一作者Zhang, Jianjun ; Jiang, Fengze
心理所单位排序1
摘要

Drug-reinforced excessive operant responding is one fundamental feature of long-lasting addiction-like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug-specific (not natural rewards) operant behavior are not entirely clear. In this study, we demonstrate a key role for one of the de novo DNA methyltransferase, DNMT3a, in the acquisition of morphine self-administration (SA) in rats. The expression of DNMT3a in the hippocampal CA1 region but not in the nucleus accumbens shell was significantly up-regulated after 1- and 7-day morphine SA (0.3 mg/kg/infusion) but not after the yoked morphine injection. On the other hand, saccharin SA did not affect the expression of DNMT3a or DNMT3b. DNMT inhibitor 5-aza-2-deoxycytidine (5-aza) microinjected into the hippocampal CA1 significantly attenuated the acquisition of morphine SA. Knockdown of DNMT3a also impaired the ability to acquire the morphine SA. Overall, these findings suggest that DNMT3a in the hippocampus plays an important role in the acquisition of morphine SA and may be a valid target to prevent the development of morphine addiction.

关键词acquisition DNMT3a hippocampal CA1 morphine self-administration
2019
DOI10.1111/adb.12730
发表期刊Addiction Biology
ISSN1355-6215
卷号25期号:2页码:1–12
收录类别SCI
出版者WILEY
WOS关键词NUCLEUS-ACCUMBENS SHELL ; INDUCED PLACE PREFERENCE ; DNA METHYLATION ; EPIGENETIC MECHANISMS ; NATURAL REWARDS ; DRUG-ADDICTION ; COCAINE ; EXPRESSION ; DOPAMINE ; HEROIN
WOS研究方向Biochemistry & Molecular Biology ; Substance Abuse
WOS类目Biochemistry & Molecular Biology ; Substance Abuse
WOS记录号WOS:000534069700013
WOS分区Q1
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/29081
专题健康与遗传心理学研究室
通讯作者Sui, Nan
作者单位1.CAS Key Laboratory of Mental Health, Institute of Psychology
2.Department of Psychology, University of Chinese Academy of Sciences
推荐引用方式
GB/T 7714
Zhang, Jianjun,Jiang, Fengze,Zheng, Wei,et al. DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats[J]. Addiction Biology,2019,25(2):1–12.
APA Zhang, Jianjun.,Jiang, Fengze.,Zheng, Wei.,Duan, Ying.,Jin, Shubo.,...&Sui, Nan.(2019).DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats.Addiction Biology,25(2),1–12.
MLA Zhang, Jianjun,et al."DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats".Addiction Biology 25.2(2019):1–12.
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