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DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats
Zhang, Jianjun; Jiang, Fengze; Zheng, Wei; Duan, Ying; Jin, Shubo; Shen, Fang; Liang, Jing; Li, Ming; Sui, Nan
First AuthorZhang, Jianjun ; Jiang, Fengze
Corresponding AuthorSui, Nan(suin@psych.ac.cn)
2019
Source PublicationAddiction Biology
ISSN1355-6215
Volume25Issue:2Pages:1–12
QuartileQ1
Contribution Rank1
AbstractDrug-reinforced excessive operant responding is one fundamental feature of long-lasting addiction-like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug-specific (not natural rewards) operant behavior are not entirely clear. In this study, we demonstrate a key role for one of the de novo DNA methyltransferase, DNMT3a, in the acquisition of morphine self-administration (SA) in rats. The expression of DNMT3a in the hippocampal CA1 region but not in the nucleus accumbens shell was significantly up-regulated after 1- and 7-day morphine SA (0.3 mg/kg/infusion) but not after the yoked morphine injection. On the other hand, saccharin SA did not affect the expression of DNMT3a or DNMT3b. DNMT inhibitor 5-aza-2-deoxycytidine (5-aza) microinjected into the hippocampal CA1 significantly attenuated the acquisition of morphine SA. Knockdown of DNMT3a also impaired the ability to acquire the morphine SA. Overall, these findings suggest that DNMT3a in the hippocampus plays an important role in the acquisition of morphine SA and may be a valid target to prevent the development of morphine addiction.
Keywordacquisition DNMT3a hippocampal CA1 morphine self-administration
DOI10.1111/adb.12730
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Substance Abuse
WOS SubjectBiochemistry & Molecular Biology ; Substance Abuse
WOS IDWOS:000534069700013
PublisherWILEY
WOS KeywordNUCLEUS-ACCUMBENS SHELL ; INDUCED PLACE PREFERENCE ; DNA METHYLATION ; EPIGENETIC MECHANISMS ; NATURAL REWARDS ; DRUG-ADDICTION ; COCAINE ; EXPRESSION ; DOPAMINE ; HEROIN
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29081
Collection健康与遗传心理学研究室
Corresponding AuthorSui, Nan
Affiliation1.CAS Key Laboratory of Mental Health, Institute of Psychology
2.Department of Psychology, University of Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Jianjun,Jiang, Fengze,Zheng, Wei,et al. DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats[J]. Addiction Biology,2019,25(2):1–12.
APA Zhang, Jianjun.,Jiang, Fengze.,Zheng, Wei.,Duan, Ying.,Jin, Shubo.,...&Sui, Nan.(2019).DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats.Addiction Biology,25(2),1–12.
MLA Zhang, Jianjun,et al."DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats".Addiction Biology 25.2(2019):1–12.
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