中国科学院心理健康重点实验室知识库

Introduction This study aimed to determine the neurocognitive basis underlying the effects of long-term high-altitude (HA) exposure on working memory (WM). Methods Using event-related potentials (ERPs), we compared the performance of an HA group (individuals who had lived at HA for 3 years but were born and raised at low altitude [LA]) to that of an LA group (individuals who had only lived at LA) on verbal and spatial n-back tasks (i.e., 1- and 2-back memory load). Results Response accuracy of the HA group was significantly decreased in comparison to the LA group in both the verbal and spatial 2-back tasks. The P2 amplitude was larger in the HA than in the LA group in the spatial, but not the verbal 2-back task. A smaller late-positive potential (LPP) amplitude was found in the HA group in both the verbal and spatial 2-back tasks. Conclusions These results suggest that HA impairs the matching (P2) process in spatial WM tasks and the maintenance (LPP) process in both verbal and spatial WM tasks, indicating that HA had a different effect on verbal and spatial 2-back task performance.