KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly

doi:10.1007/s11682-019-00047-1

	KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly
	Li Rui1,2 ; Wan Wenyu 1,2; Li Juan1,2,3,4
第一作者	Li Rui
通讯作者	Li, Juan(lijuan@psych.ac.cn)
心理所单位排序	1
摘要	Genetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 gene has been linked to episodic memory and cognitive aging; yet, the neural mechanism underlying this association remains to be fully understood. Using the magnetic resonance imaging (MRI) technique, this study investigated the effect of KIBRA polymorphism on gray matter volume in 37 healthy, Chinese adults from the older population. Voxel-based morphometry (VBM) analysis revealed that KIBRA gene selectivity influences the prefrontal cortex and the parahippocampal cortex. The gray matter volume (GMV) in these structures is significantly lower in KIBRA C-allele carriers than in TT carriers. Moreover, multi-voxel pattern correlation analysis revealed that decreased prefrontal GMV could in turn affect individual cognitive function in C-allele carriers; whereas, TT individuals utilized more integrated gray matter volume in whole-brain voxels to achieve relatively better cognitive function. Overall, the findings suggest that the KIBRA rs17070145 polymorphism modulates gray matter volume, which in turn further influences cognitive function in the elderly.
关键词	KIBRA Gray matter volume VBM Aging Prefrontal
	2019
语种	英语
DOI	10.1007/s11682-019-00047-1
发表期刊	Brain Imaging and Behavior
ISSN	1931-7557
卷号	14 期号:5 页码:https://doi.org/10.1007/s11682-019-00047-1
收录类别	SCI
资助项目	National Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31470998] ; National Natural Science Foundation of China[61673374] ; National Natural Science Foundation of China[31711530157] ; National Natural Science Foundation of China[31861133011] ; Beijing Municipal Science and Technology Commission[Z171100000117006] ; Beijing Municipal Science and Technology Commission[Z171100008217006] ; National Key Research and Development Program of China[2018YFC2001701] ; National Key Research and Development Program of China[2017YFB1401203] ; National Key Research and Development Program of China[2018YFC2000303] ; National Key Research and Development Program of China[2016YFC1305904]
出版者	SPRINGER
WOS关键词	AGE-RELATED DECLINE ; ALZHEIMERS-DISEASE ; EPISODIC MEMORY ; PYRAMIDAL CELLS ; GENE VARIANTS ; DEFAULT-MODE ; BRAIN ; ASSOCIATION ; PERFORMANCE ; IMPACT
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000579512100009
Q分类	Q2
资助机构	National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; National Key Research and Development Program of China
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/29095
专题	中国科学院心理健康重点实验室
通讯作者	Li Juan
作者单位	1.Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China 2.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China 3.Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China 4.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
第一作者单位	中国科学院心理研究所
通讯作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Li Rui,Wan Wenyu,Li Juan. KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly[J]. Brain Imaging and Behavior,2019,14(5):https://doi.org/10.1007/s11682-019-00047-1.
APA	Li Rui,Wan Wenyu,&Li Juan.(2019).KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly.Brain Imaging and Behavior,14(5),https://doi.org/10.1007/s11682-019-00047-1.
MLA	Li Rui,et al."KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly".Brain Imaging and Behavior 14.5(2019):https://doi.org/10.1007/s11682-019-00047-1.

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
2019_LIRUI_BIB_KIBRA（2063KB）	期刊论文	作者接受稿	限制开放	CC BY-NC-SA	请求全文