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KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly
Li Rui1,2; Wan Wenyu1,2; Li Juan1,2,3,4
First AuthorLi Rui
Corresponding AuthorLi, Juan(lijuan@psych.ac.cn)
Contribution Rank1
AbstractGenetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 gene has been linked to episodic memory and cognitive aging; yet, the neural mechanism underlying this association remains to be fully understood. Using the magnetic resonance imaging (MRI) technique, this study investigated the effect of KIBRA polymorphism on gray matter volume in 37 healthy, Chinese adults from the older population. Voxel-based morphometry (VBM) analysis revealed that KIBRA gene selectivity influences the prefrontal cortex and the parahippocampal cortex. The gray matter volume (GMV) in these structures is significantly lower in KIBRA C-allele carriers than in TT carriers. Moreover, multi-voxel pattern correlation analysis revealed that decreased prefrontal GMV could in turn affect individual cognitive function in C-allele carriers; whereas, TT individuals utilized more integrated gray matter volume in whole-brain voxels to achieve relatively better cognitive function. Overall, the findings suggest that the KIBRA rs17070145 polymorphism modulates gray matter volume, which in turn further influences cognitive function in the elderly.
KeywordKIBRA Gray matter volume VBM Aging Prefrontal
2019
Language英语
DOI10.1007/s11682-019-00047-1
Source PublicationBrain Imaging and Behavior
ISSN1931-7557
Volume14Issue:5Pages:https://doi.org/10.1007/s11682-019-00047-1
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31470998] ; National Natural Science Foundation of China[61673374] ; National Natural Science Foundation of China[31711530157] ; National Natural Science Foundation of China[31861133011] ; Beijing Municipal Science and Technology Commission[Z171100000117006] ; Beijing Municipal Science and Technology Commission[Z171100008217006] ; National Key Research and Development Program of China[2018YFC2001701] ; National Key Research and Development Program of China[2017YFB1401203] ; National Key Research and Development Program of China[2018YFC2000303] ; National Key Research and Development Program of China[2016YFC1305904]
PublisherSPRINGER
WOS KeywordAGE-RELATED DECLINE ; ALZHEIMERS-DISEASE ; EPISODIC MEMORY ; PYRAMIDAL CELLS ; GENE VARIANTS ; DEFAULT-MODE ; BRAIN ; ASSOCIATION ; PERFORMANCE ; IMPACT
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000579512100009
QuartileQ2
Funding OrganizationNational Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; National Key Research and Development Program of China
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29095
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi Juan
Affiliation1.Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China
2.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
3.Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
4.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li Rui,Wan Wenyu,Li Juan. KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly[J]. Brain Imaging and Behavior,2019,14(5):https://doi.org/10.1007/s11682-019-00047-1.
APA Li Rui,Wan Wenyu,&Li Juan.(2019).KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly.Brain Imaging and Behavior,14(5),https://doi.org/10.1007/s11682-019-00047-1.
MLA Li Rui,et al."KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly".Brain Imaging and Behavior 14.5(2019):https://doi.org/10.1007/s11682-019-00047-1.
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