The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine

doi:10.1007/s00213-019-05272-6

	The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine
	Bai, Yunjing1,2 ; Zhang, Yue 1,2; Jiang, Shaofei 1,2; Zheng, Xigeng1,2 ; Liu, Zhengkui1,2
通讯作者	Bai, Yunjing(baiyj@psych.ac.cn) ; Liu, Zhengkui(liuzk@psych.ac.cn)
摘要	Background Negative affective states, e.g., anhedonia, may be linked to the long-lasting motivational processes associated with relapse. Here, this study investigated whether, and how, anhedonic states are influenced by stressful events that contribute to craving and relapse. Methods All male rats were pretreated with a binge-like morphine paradigm for five days. After 12 to 16 days of withdrawal, rats were subjected to a one-hour free consumption test or three operant tasks with increasing cost/benefit ratio, i.e., fixed ratio 1 (FR1), progressive ratio (PR), and PR-punishment procedure of reinforcement, with sucrose solutions of three concentrations (4%, 15%, and 60%) as rewards. The consumption and operant responses under FR1 and PR procedures were measured following exposure to acute foot-shock stress (intermittent foot shock, 0.5 mA x 0.5 s x 10 min; mean intershock interval, 40 s), and the operant responses for 60% sucrose solution under PR-punishment procedure was measured following a forced-swim stress (5 minutes). Result Foot-shock stress increased water consumption in a subpopulation of rats and decreased consumption of sucrose solutions, while it did not influence the operant responses for sucrose solutions under either FR1 or PR procedure. The forced-swim stress reduced operant responses for 60% sucrose solution under PR-punishment procedure, but did not influence responding for 60% sucrose solution under PR procedure. In addition, the forced-swim stress also elevated anxiety level of rats in an open area test. Conclusions Acute stress induced hedonic but not motivational deficit for sucrose reward in protracted drug-abstinent animals. Additional negative emotional states besides anhedonia were evoked by acute stress.
关键词	Anhedonia Protracted abstinence Natural reward Consummatory behavior Motivational behavior
	2019-11-01
语种	英语
DOI	10.1007/s00213-019-05272-6
发表期刊	PSYCHOPHARMACOLOGY
ISSN	0033-3158
卷号	236 期号:11 页码:3197-3208
收录类别	SCI
资助项目	CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016K01] ; Evaluation and Intervention Technology Research for Post-traumatic Stress Patients Population[JCYJ20170413170301569] ; National Natural Science Foundation of China[31000463] ; Beijing Natural Science Foundation[7192124]
出版者	SPRINGER
WOS关键词	COCAINE-SEEKING BEHAVIOR ; SEXUAL-BEHAVIOR ; D-AMPHETAMINE ; APPETITIVE BEHAVIOR ; SOCIAL DEFEAT ; ANHEDONIA ; REWARD ; DRUG ; ADDICTION ; RELAPSE
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目	Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000494045800011
资助机构	CAS Key Laboratory of Mental Health, Institute of Psychology ; Evaluation and Intervention Technology Research for Post-traumatic Stress Patients Population ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/29100
专题	中国科学院心理健康重点实验室健康与遗传心理学研究室
通讯作者	Bai, Yunjing; Liu, Zhengkui
作者单位	1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, 19A Yuquan Rd, Beijing 100049, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Bai, Yunjing,Zhang, Yue,Jiang, Shaofei,et al. The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine[J]. PSYCHOPHARMACOLOGY,2019,236(11):3197-3208.
APA	Bai, Yunjing,Zhang, Yue,Jiang, Shaofei,Zheng, Xigeng,&Liu, Zhengkui.(2019).The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine.PSYCHOPHARMACOLOGY,236(11),3197-3208.
MLA	Bai, Yunjing,et al."The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine".PSYCHOPHARMACOLOGY 236.11(2019):3197-3208.

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