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The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine
Bai, Yunjing1,2; Zhang, Yue1,2; Jiang, Shaofei1,2; Zheng, Xigeng1,2; Liu, Zhengkui1,2
Corresponding AuthorBai, Yunjing(baiyj@psych.ac.cn) ; Liu, Zhengkui(liuzk@psych.ac.cn)
2019-11-01
Source PublicationPSYCHOPHARMACOLOGY
ISSN0033-3158
Volume236Issue:11Pages:3197-3208
AbstractBackground Negative affective states, e.g., anhedonia, may be linked to the long-lasting motivational processes associated with relapse. Here, this study investigated whether, and how, anhedonic states are influenced by stressful events that contribute to craving and relapse. Methods All male rats were pretreated with a binge-like morphine paradigm for five days. After 12 to 16 days of withdrawal, rats were subjected to a one-hour free consumption test or three operant tasks with increasing cost/benefit ratio, i.e., fixed ratio 1 (FR1), progressive ratio (PR), and PR-punishment procedure of reinforcement, with sucrose solutions of three concentrations (4%, 15%, and 60%) as rewards. The consumption and operant responses under FR1 and PR procedures were measured following exposure to acute foot-shock stress (intermittent foot shock, 0.5 mA x 0.5 s x 10 min; mean intershock interval, 40 s), and the operant responses for 60% sucrose solution under PR-punishment procedure was measured following a forced-swim stress (5 minutes). Result Foot-shock stress increased water consumption in a subpopulation of rats and decreased consumption of sucrose solutions, while it did not influence the operant responses for sucrose solutions under either FR1 or PR procedure. The forced-swim stress reduced operant responses for 60% sucrose solution under PR-punishment procedure, but did not influence responding for 60% sucrose solution under PR procedure. In addition, the forced-swim stress also elevated anxiety level of rats in an open area test. Conclusions Acute stress induced hedonic but not motivational deficit for sucrose reward in protracted drug-abstinent animals. Additional negative emotional states besides anhedonia were evoked by acute stress.
KeywordAnhedonia Protracted abstinence Natural reward Consummatory behavior Motivational behavior
DOI10.1007/s00213-019-05272-6
Indexed BySCI
Language英语
Funding OrganizationCAS Key Laboratory of Mental Health, Institute of Psychology ; Evaluation and Intervention Technology Research for Post-traumatic Stress Patients Population ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
Funding ProjectCAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016K01] ; Evaluation and Intervention Technology Research for Post-traumatic Stress Patients Population[JCYJ20170413170301569] ; National Natural Science Foundation of China[31000463] ; Beijing Natural Science Foundation[7192124]
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectNeurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000494045800011
PublisherSPRINGER
WOS KeywordCOCAINE-SEEKING BEHAVIOR ; SEXUAL-BEHAVIOR ; D-AMPHETAMINE ; APPETITIVE BEHAVIOR ; SOCIAL DEFEAT ; ANHEDONIA ; REWARD ; DRUG ; ADDICTION ; RELAPSE
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29100
Collection中国科学院心理健康重点实验室
健康与遗传心理学研究室
Corresponding AuthorBai, Yunjing; Liu, Zhengkui
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, 19A Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Bai, Yunjing,Zhang, Yue,Jiang, Shaofei,et al. The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine[J]. PSYCHOPHARMACOLOGY,2019,236(11):3197-3208.
APA Bai, Yunjing,Zhang, Yue,Jiang, Shaofei,Zheng, Xigeng,&Liu, Zhengkui.(2019).The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine.PSYCHOPHARMACOLOGY,236(11),3197-3208.
MLA Bai, Yunjing,et al."The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine".PSYCHOPHARMACOLOGY 236.11(2019):3197-3208.
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