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The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder
Ma, Yue-Jiao1; Wang, Dong-Fang2; Yuan, Ming1; Zhang, Xiao-Jie1; Long, Jiang1; Chen, Shu-Bao1; Wu, Qiu-Xia1; Wang, Xu-Yi1; Patel, Marguerite3; Verrico, Christopher D.3; Liu, Tie-Qiao1; Zhang, Xiang-Yang4,5
第一作者Ma, Yue-Jiao
通讯作者邮箱liutieqiao123@csu.edu.cn ; xiang.y.zhang@uth.tmc.edu ; zhangxy9@gmail.com
摘要

BackgroundMetabolic disturbances have been correlated with suicidality, but little is known about the association between suicide risk and metabolic disturbances among individuals with depression. This study was to evaluate the prevalence and clinical correlations, especially cardio-metabolic associated factors of recent suicide attempts in Chinese patients with major depressive disorder (MDD).MethodsA total of 288 MDD inpatients were recruited. Their clinical and demographic data together with plasma glucose, lipid and thyroid function parameters were collected. Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS) and Eysenck Personality Questionnaire (EPQ) were rated for most of the patients.ResultsOf these MDD inpatients, 20.14% had attempted suicide during the past 1 month. Compared to those who had not attempted suicide, the suicide attempters had a significantly longer duration of illness, lower low-density lipoprotein (LDL) cholesterol, lower total cholesterol, and more psychotic symptoms. However, all these significant results did not survive after the bonferroni correction (all p>0.05). A logistic regression analysis indicated that suicide attempts were associated with the lower total cholesterol and more psychotic symptoms.ConclusionsOur findings support the hypothesis of the association of low plasma cholesterol level and recent suicidal attempts in patients with MDD.

关键词Depression Suicide attempt Prevalence Clinical correlates Metabolic disturbance
2019-05-10
语种英语
DOI10.1186/s12888-019-2131-6
发表期刊BMC PSYCHIATRY
ISSN1471-244X
卷号19页码:7
期刊论文类型article
收录类别SCI
资助项目National Key R&D Program of China[2017YFC1310400] ; National Natural Science Foundation of China[81371465] ; National Natural Science Foundation of China[81671324]
出版者BMC
WOS关键词LOW SERUM-CHOLESTEROL ; CENTRAL SEROTONERGIC ACTIVITY ; BODY-MASS INDEX ; LIPID PROFILE ; RISK ; IDEATION ; ASSOCIATION ; BEHAVIOR ; BIPOLAR ; INDIVIDUALS
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000467602800001
资助机构National Key R&D Program of China ; National Natural Science Foundation of China
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/29114
专题健康与遗传心理学研究室
通讯作者Liu, Tie-Qiao; Zhang, Xiang-Yang
作者单位1.Cent S Univ, China Natl Clin Res Ctr Mental Hlth Disorders, Key Lab Psychiat & Mental Hlth Hunan Prov, Xiangya Hosp 2,Dept Psychiat,Chinese Natl Technol, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
2.Cent S Univ, Psychosomat Hlth Inst, Xiangya Hosp 3, Changsha, Hunan, Peoples R China
3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, 1941 East Rd, Houston, TX 77054 USA
通讯作者单位中国科学院心理研究所
推荐引用方式
GB/T 7714
Ma, Yue-Jiao,Wang, Dong-Fang,Yuan, Ming,et al. The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder[J]. BMC PSYCHIATRY,2019,19:7.
APA Ma, Yue-Jiao.,Wang, Dong-Fang.,Yuan, Ming.,Zhang, Xiao-Jie.,Long, Jiang.,...&Zhang, Xiang-Yang.(2019).The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder.BMC PSYCHIATRY,19,7.
MLA Ma, Yue-Jiao,et al."The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder".BMC PSYCHIATRY 19(2019):7.
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