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The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder
Ma, Yue-Jiao1; Wang, Dong-Fang2; Yuan, Ming1; Zhang, Xiao-Jie1; Long, Jiang1; Chen, Shu-Bao1; Wu, Qiu-Xia1; Wang, Xu-Yi1; Patel, Marguerite3; Verrico, Christopher D.3; Liu, Tie-Qiao1; Zhang, Xiang-Yang4,5
First AuthorMa, Yue-Jiao
2019-05-10
Source PublicationBMC PSYCHIATRY
Correspondent Emailliutieqiao123@csu.edu.cn ; xiang.y.zhang@uth.tmc.edu ; zhangxy9@gmail.com
ISSN1471-244X
Subtypearticle
Volume19Pages:7
Abstract

BackgroundMetabolic disturbances have been correlated with suicidality, but little is known about the association between suicide risk and metabolic disturbances among individuals with depression. This study was to evaluate the prevalence and clinical correlations, especially cardio-metabolic associated factors of recent suicide attempts in Chinese patients with major depressive disorder (MDD).MethodsA total of 288 MDD inpatients were recruited. Their clinical and demographic data together with plasma glucose, lipid and thyroid function parameters were collected. Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS) and Eysenck Personality Questionnaire (EPQ) were rated for most of the patients.ResultsOf these MDD inpatients, 20.14% had attempted suicide during the past 1 month. Compared to those who had not attempted suicide, the suicide attempters had a significantly longer duration of illness, lower low-density lipoprotein (LDL) cholesterol, lower total cholesterol, and more psychotic symptoms. However, all these significant results did not survive after the bonferroni correction (all p>0.05). A logistic regression analysis indicated that suicide attempts were associated with the lower total cholesterol and more psychotic symptoms.ConclusionsOur findings support the hypothesis of the association of low plasma cholesterol level and recent suicidal attempts in patients with MDD.

KeywordDepression Suicide attempt Prevalence Clinical correlates Metabolic disturbance
DOI10.1186/s12888-019-2131-6
Indexed BySCI
Language英语
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China
Funding ProjectNational Key R&D Program of China[2017YFC1310400] ; National Natural Science Foundation of China[81371465] ; National Natural Science Foundation of China[81671324]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000467602800001
PublisherBMC
WOS KeywordLOW SERUM-CHOLESTEROL ; CENTRAL SEROTONERGIC ACTIVITY ; BODY-MASS INDEX ; LIPID PROFILE ; RISK ; IDEATION ; ASSOCIATION ; BEHAVIOR ; BIPOLAR ; INDIVIDUALS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29114
Collection健康与遗传心理学研究室
Corresponding AuthorLiu, Tie-Qiao; Zhang, Xiang-Yang
Affiliation1.Cent S Univ, China Natl Clin Res Ctr Mental Hlth Disorders, Key Lab Psychiat & Mental Hlth Hunan Prov, Xiangya Hosp 2,Dept Psychiat,Chinese Natl Technol, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
2.Cent S Univ, Psychosomat Hlth Inst, Xiangya Hosp 3, Changsha, Hunan, Peoples R China
3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, 1941 East Rd, Houston, TX 77054 USA
Recommended Citation
GB/T 7714
Ma, Yue-Jiao,Wang, Dong-Fang,Yuan, Ming,et al. The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder[J]. BMC PSYCHIATRY,2019,19:7.
APA Ma, Yue-Jiao.,Wang, Dong-Fang.,Yuan, Ming.,Zhang, Xiao-Jie.,Long, Jiang.,...&Zhang, Xiang-Yang.(2019).The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder.BMC PSYCHIATRY,19,7.
MLA Ma, Yue-Jiao,et al."The prevalence, metabolic disturbances and clinical correlates of recent suicide attempts in Chinese inpatients with major depressive disorder".BMC PSYCHIATRY 19(2019):7.
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