PSYCH OpenIR  > 中国科学院心理健康重点实验室
Functional connectivity of the default mode network is associated with prospection in schizophrenia patients and individuals with social anhedonia
Yang, Zhuo-ya1,2; Zhang, Rui-ting1,2; Li, Ying1,2,3; Wang, Yi1; Wang, Yong-ming1,2,4,5; Wang, Shuang-kun6; Ongur, Dost7; Cheung, Eric F. C.8; Chan, Raymond C. K.1,2
First AuthorZhuo-ya Yang
2019-06-08
Source PublicationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Correspondent Emailr.c.k. chan(rckchan@psych.ac.cn)
ISSN0278-5846
Subtypearticle
Volume92Pages:412-420
Contribution Rank1
Abstract

Background: Prospection, which is closely related to negative symptoms in patients with schizophrenia, is mainly associated with the Default Mode Network (DMN). Although abnormalities of the DMN have been reported in schizophrenia patients and at-risk individuals, little is known about the relationship between functional connectivity of the DMN and prospection in these clinical and subclinical populations. Method: Study 1 recruited 40 schizophrenia patients and 29 healthy controls, while 31 individuals with social anhedonia (SocAhn) and 28 controls participated in Study 2. Participants in both studies were asked to complete a prospection task and underwent resting-state functional MRI scans. Eleven regions of interest (ROIs) in the DMN were defined. Functional connectivity between each ROI and whole brain voxels were calculated and compared between groups (schizophrenia vs. control and SocAhn vs. control). Correlation analysis was conducted between altered functional connectivity and prospection variables in the schizophrenia and SocAhn groups. Results: Schizophrenia patients showed both hyper-connectivity and hypo-connectivity at the medial temporal lobe (MTL) subsystem of the DMN. Decreased connectivity between the ventral medial prefrontal cortex (vMPFC) and the right superior temporal gyrus (rSTG) was correlated with poor thought/emotion details in prospection. In individuals with SocAhn, decreased connectivity between the retrosplenial cortex (Rsp), a region of the MTL subsystem, and the right fusiform gyrus, was found and this was correlated with their prospection performance. Conclusion: Altered functional connectivity of the key nodes of the MTL subsystem was found in both patients with schizophrenia and individuals with SocAhn. Moreover, hypo-connectivity of the vMPFC was found to be correlated with prospection impairments in schizophrenia patients.

KeywordProspection Resting-state Schizophrenia Social anhedonia
DOI10.1016/j.pnpbp.2019.02.008
Indexed BySCI
Language英语
Funding OrganizationNational Science Fund China ; National Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; Beijing Training Project for the Leading Talents in Science and Technology
Funding ProjectNational Science Fund China[81571317] ; National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020]
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000466837000040
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordEPISODIC FUTURE THINKING ; VENTROMEDIAL PREFRONTAL CORTEX ; MENTAL TIME-TRAVEL ; MEMORY ; EMOTION ; DEFICITS ; EVENTS ; BRAIN ; ABNORMALITIES ; METAANALYSIS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29118
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Haidian Dist Mental Hlth Prevent Treatment Hosp, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100190, Peoples R China
5.Sinodanish Ctr Educ & Res, Beijing 100190, Peoples R China
6.Capital Med Univ, Beijing Chao Yang Hosp, Dept Radiol, Beijing, Peoples R China
7.Harvard Med Sch, Dept Psychiat, McLean Hosp, 115 Mill St, Belmont, MA 02478 USA
8.Castle Peak Hosp, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Yang, Zhuo-ya,Zhang, Rui-ting,Li, Ying,et al. Functional connectivity of the default mode network is associated with prospection in schizophrenia patients and individuals with social anhedonia[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2019,92:412-420.
APA Yang, Zhuo-ya.,Zhang, Rui-ting.,Li, Ying.,Wang, Yi.,Wang, Yong-ming.,...&Chan, Raymond C. K..(2019).Functional connectivity of the default mode network is associated with prospection in schizophrenia patients and individuals with social anhedonia.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,92,412-420.
MLA Yang, Zhuo-ya,et al."Functional connectivity of the default mode network is associated with prospection in schizophrenia patients and individuals with social anhedonia".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 92(2019):412-420.
Files in This Item:
File Name/Size DocType Version Access License
Functional connectiv(643KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Zhuo-ya]'s Articles
[Zhang, Rui-ting]'s Articles
[Li, Ying]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Zhuo-ya]'s Articles
[Zhang, Rui-ting]'s Articles
[Li, Ying]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Zhuo-ya]'s Articles
[Zhang, Rui-ting]'s Articles
[Li, Ying]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Functional connectivity of the default mode network is associated with prospection in schizophrenia patients and individuals with social anhedonia.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.