PSYCH OpenIR  > 健康与遗传心理学研究室
Gender differences in the prevalence and clinical features of comorbid depressive symptoms in never-treated first-episode patientes with schizophrenia
Dong-Mei Wang1; Guang-Ya Zhang2; Xiang-Dong Dub2; Qiu-Fang Jia2; Zheng-Kang Qianb2; Guang-Zhong Yin2; Da-Chun Chen3; Mei-Hong Xiu3; Yu-Ping Ning4,5; Xing-Bing Huang4; Feng-Chun Wu4,5; Xiang-Yang Zhang1,4
First AuthorDong-Mei Wang
2019-05
Source PublicationThe Journal Clinical psychiatry
Correspondent Emailfeng-chun wu (13580380071@163.com) ; xiang-yang zhang (zhangxy@psych.ac.cn)
SubtypeArticle
Volume不详Issue:不详Pages:不详
Other Abstract

Background: Many studies have indicated a gender-specific effect in many aspects of schizophrenia. The presence of depressive symptomatology exists in all phase of schizophrenia patients. The aim of this study is to investigate the gender difference in the proportion of comorbid depressive symptoms and gender-specific relationships between depressive symptoms and clinical correlates in Chinese never-treated first-episode (NTFE) patients with schizophrenia, which have not been reported yet.

Method: Using the cross-sectional design, 240 NTFE inpatients (males/females = 111/129) meeting DSM-IV criteria of schizophrenia were recruited. The Positive and Negative Symptoms Scale (PANSS) was used for the psychopathology and the Hamilton Depression Rating Scale (HDRS) for the comorbid depressive symptoms. This study was conducted from June 2013 to December 2015.

Results: The proportion of patients with depressive symptoms (total score in HDRS-17 ≥ 8) in male is significantly higher than in female (male: 62.2%, female: 48.1%; c2 = 4.28, df = 1, p = 0.039). Male patients had significantly greater depressive symptoms shown on HDRS than female patients (t = 2.75, df = 1, 238, p = 0.006). Further, we found that age, the age of onset, smoking rate, and PANSS total, general psychopathology, negative symptoms, and cognitive factor subscale scores favored significant gender differences in female patients (all p<0.05). Interestingly, we found gender differences in the correlation between the HDRS score and clinical phenotype, showing that in male patients, the PANSS general psychopathology subscore (beta = 0.75, t = 7.72, p = 0000) and PANSS total score (beta = 0.44, t = 4.81, p = 0.000) significantly predicted the HDRS-17 total score, while in female patients, the PANSS general psychopathology subscore (beta = 0.74, t = 8.45, p = 0000) and the PANSS total score (beta = 0.47, t = 5.71, p = 0.000), the PANSS cognitive factor (beta = 0.24, t = 2.60, p = 0.011) significantly predicted the HDRS-17 total score.

Conclusions: Our results indicate gender differences in the frequency and severity of comorbid depressive symptoms, as well as in associations between depressive symptoms and clinical correlates in NTFE schizophrenia.

KeywordGender difference schizophrenia comorbid depression prevalence
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29135
Collection健康与遗传心理学研究室
Affiliation1.CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
2.Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu Province, China
3.Beijing Huilongguan Hospital, Beijing, China
4.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
5.Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Dong-Mei Wang,Guang-Ya Zhang,Xiang-Dong Dub,et al. Gender differences in the prevalence and clinical features of comorbid depressive symptoms in never-treated first-episode patientes with schizophrenia[J]. The Journal Clinical psychiatry,2019,不详(不详):不详.
APA Dong-Mei Wang.,Guang-Ya Zhang.,Xiang-Dong Dub.,Qiu-Fang Jia.,Zheng-Kang Qianb.,...&Xiang-Yang Zhang.(2019).Gender differences in the prevalence and clinical features of comorbid depressive symptoms in never-treated first-episode patientes with schizophrenia.The Journal Clinical psychiatry,不详(不详),不详.
MLA Dong-Mei Wang,et al."Gender differences in the prevalence and clinical features of comorbid depressive symptoms in never-treated first-episode patientes with schizophrenia".The Journal Clinical psychiatry 不详.不详(2019):不详.
Files in This Item:
File Name/Size DocType Version Access License
Gender differences i(181KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Dong-Mei Wang]'s Articles
[Guang-Ya Zhang]'s Articles
[Xiang-Dong Dub]'s Articles
Baidu academic
Similar articles in Baidu academic
[Dong-Mei Wang]'s Articles
[Guang-Ya Zhang]'s Articles
[Xiang-Dong Dub]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Dong-Mei Wang]'s Articles
[Guang-Ya Zhang]'s Articles
[Xiang-Dong Dub]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Gender differences in the prevalence and clinical features of comorbid depressive symptoms in never-treated first-episode patientes with schizophrenia.docx
Format: Microsoft Word
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.