Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism

doi:10.1016/j.jad.2019.05.065

	Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism
	Zhao Jingjie 1,2; Gao Xuesong 2; Wang Anna 2; Wang Yongzhi 2; Du Yi 2; Li Li 2; Li Mingzhen 1; Chong Li1,3 ; Jin Xiaoying 1; Zhao Mei1,3
通讯作者	Zhao Mei(zhaomei@psych.ac.cn)
摘要	Background: Recent studies have indicated that inflammatory pathways and hypothalamic-pituitary-adrenal (HPA) axis function may be responsible for the interaction between pain and depression. Methods: Animals were examined for depressive and painful behavior following exposure to chronic unpredictable mild stress (CUMS) and chronic corticosterone (CORT) treatment. Subsequently, serum cytokines, adrenocorticotropic hormone (ACTH) and CORT were measured by enzyme-linked immunosorbent assay (ELISA). mRNA expression of cytokines in the brain were measured by quantitative PCR (qPCR). Results: The present study found that both CUMS and chronic CORT treatment induced behavioral changes of depression comorbid hyperalgesia. Moreover, both the treatments increased levels of serum ACTH, CORT, and cytokines including tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL1 beta), interleukin 6 (IL6), and Caspase 1 (CASP1). Following CUMS, IL1 beta levels were found to be elevated in all examined regions, including the raphe nuclei, thalamus, hippocampus, prefrontal cortex, and pituitary. In the raphe nuclei particularly, CUMS elevated all examined cytokine levels. Chronic CORT treatment, however, produced IL1 beta elevation in the hippocampus and the pituitary, with showing elevated levels in all examined cytokines. Limitation: To clarify the causal relationship between behavioral changes and altered cytokine levels via either antidepressant treatment or blockage of pre-inflammatory cytokine production, further studies should be conducted. Conclusions: Despite similar behavioral consequences, hypercortisolism and peripheral inflammation, CUMS and chronic CORT treatment seem to produce differing inflammatory brain responses.
关键词	Pain Depression Chronic unpredictable mild stress Corticosterone Hypothalamic-pituitary-adrenal (HPA) axis Inflammation
	2019-09-01
语种	英语
DOI	10.1016/j.jad.2019.05.065
发表期刊	JOURNAL OF AFFECTIVE DISORDERS
ISSN	0165-0327
卷号	256 页码:117-124
收录类别	SCI
资助项目	National Natural Science Foundation of China[91132728] ; National Natural Science Foundation of China[31741062] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Beijing Administration of Traditional Chinese Medicine[QN2018-33] ; Beijing Municipal Administration of Hospitals Incubating Program[PZ2017024] ; Beijing Natural Science Foundation[7172063] ; Beijing Health System Training Program for High Level Technique Talents[2014-3-001]
出版者	ELSEVIER
WOS关键词	PREFRONTAL CORTEX ; MAJOR DEPRESSION ; PAIN PERCEPTION ; GLUCOCORTICOIDS ; INFLAMMATION ; DYSFUNCTION ; DISORDER
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:000491354400015
资助机构	National Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Beijing Administration of Traditional Chinese Medicine ; Beijing Municipal Administration of Hospitals Incubating Program ; Beijing Natural Science Foundation ; Beijing Health System Training Program for High Level Technique Talents
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/29141
专题	中国科学院心理健康重点实验室
通讯作者	Zhao Mei
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Capital Med Univ, Beijing Friendship Hosp, Beijing 100050, Peoples R China 3.Univ Chinese Acad Sci, Beijing 101408, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zhao Jingjie,Gao Xuesong,Wang Anna,et al. Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,256:117-124.
APA	Zhao Jingjie.,Gao Xuesong.,Wang Anna.,Wang Yongzhi.,Du Yi.,...&Zhao Mei.(2019).Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism.JOURNAL OF AFFECTIVE DISORDERS,256,117-124.
MLA	Zhao Jingjie,et al."Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism".JOURNAL OF AFFECTIVE DISORDERS 256(2019):117-124.

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