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Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism
Zhao Jingjie1,2; Gao Xuesong2; Wang Anna2; Wang Yongzhi2; Du Yi2; Li Li2; Li Mingzhen1; Chong Li1,3; Jin Xiaoying1; Zhao Mei1,3
Corresponding AuthorZhao Mei(zhaomei@psych.ac.cn)
2019-09-01
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
Volume256Pages:117-124
AbstractBackground: Recent studies have indicated that inflammatory pathways and hypothalamic-pituitary-adrenal (HPA) axis function may be responsible for the interaction between pain and depression. Methods: Animals were examined for depressive and painful behavior following exposure to chronic unpredictable mild stress (CUMS) and chronic corticosterone (CORT) treatment. Subsequently, serum cytokines, adrenocorticotropic hormone (ACTH) and CORT were measured by enzyme-linked immunosorbent assay (ELISA). mRNA expression of cytokines in the brain were measured by quantitative PCR (qPCR). Results: The present study found that both CUMS and chronic CORT treatment induced behavioral changes of depression comorbid hyperalgesia. Moreover, both the treatments increased levels of serum ACTH, CORT, and cytokines including tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL1 beta), interleukin 6 (IL6), and Caspase 1 (CASP1). Following CUMS, IL1 beta levels were found to be elevated in all examined regions, including the raphe nuclei, thalamus, hippocampus, prefrontal cortex, and pituitary. In the raphe nuclei particularly, CUMS elevated all examined cytokine levels. Chronic CORT treatment, however, produced IL1 beta elevation in the hippocampus and the pituitary, with showing elevated levels in all examined cytokines. Limitation: To clarify the causal relationship between behavioral changes and altered cytokine levels via either antidepressant treatment or blockage of pre-inflammatory cytokine production, further studies should be conducted. Conclusions: Despite similar behavioral consequences, hypercortisolism and peripheral inflammation, CUMS and chronic CORT treatment seem to produce differing inflammatory brain responses.
KeywordPain Depression Chronic unpredictable mild stress Corticosterone Hypothalamic-pituitary-adrenal (HPA) axis Inflammation
DOI10.1016/j.jad.2019.05.065
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Beijing Administration of Traditional Chinese Medicine ; Beijing Municipal Administration of Hospitals Incubating Program ; Beijing Natural Science Foundation ; Beijing Health System Training Program for High Level Technique Talents
Funding ProjectNational Natural Science Foundation of China[91132728] ; National Natural Science Foundation of China[31741062] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Beijing Administration of Traditional Chinese Medicine[QN2018-33] ; Beijing Municipal Administration of Hospitals Incubating Program[PZ2017024] ; Beijing Natural Science Foundation[7172063] ; Beijing Health System Training Program for High Level Technique Talents[2014-3-001]
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000491354400015
PublisherELSEVIER
WOS KeywordPREFRONTAL CORTEX ; MAJOR DEPRESSION ; PAIN PERCEPTION ; GLUCOCORTICOIDS ; INFLAMMATION ; DYSFUNCTION ; DISORDER
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29141
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhao Mei
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Beijing 100050, Peoples R China
3.Univ Chinese Acad Sci, Beijing 101408, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhao Jingjie,Gao Xuesong,Wang Anna,et al. Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,256:117-124.
APA Zhao Jingjie.,Gao Xuesong.,Wang Anna.,Wang Yongzhi.,Du Yi.,...&Zhao Mei.(2019).Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism.JOURNAL OF AFFECTIVE DISORDERS,256,117-124.
MLA Zhao Jingjie,et al."Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism".JOURNAL OF AFFECTIVE DISORDERS 256(2019):117-124.
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