PSYCH OpenIR  > 中国科学院心理健康重点实验室
Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression
Li, Mingzhen1,2; Teng, Huajing3; Sun, Guangqiang1; Zhao, Jingjie1,6; Fan, Min2; Zhao, Zhenlin2; Zhou, JianJun4; Zhao, Mei1,5
Corresponding AuthorZhou, JianJun(zhoujj_2000@aliyun.com) ; Zhao, Mei(zhaomei@psych.ac.cn)
2019-06-01
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
Volume276Pages:79-86
AbstractCorticosterone (CORT), the main HPA-axis glucocorticoid hormone in rodents, is involved in the regulation of animal stress responses. However, the neural mechanisms underlying the effects of corticosteroids on depression are yet to be elucidated. We found that fluoxetine reversed neurite growth inhibition induced by COAT in PC12 cells, a widely used model system for neurobiological and neurotoxicological studies. Transcriptome profiling showed that 1,609 genes were up-regulated, whereas 1,764 genes were down-regulated significantly in the CORT group in comparison with the Control group. Of them, the expression of 589 DEGs was reversed after fluoxetine treatment, and genes related to cell morphogenesis, neurite growth, and immune function were involved in the neuroprotective effect of fluoxetine against CORT. Furthermore, expression of neurite growth-related genes, such as such as Calpain 2 (Capn2), vesicle-associated membrane protein 7 (Vamp7) and C-type natriuretic peptide (Cnp), altered in a brain region- or treatment-specific manner in the animal models of depression. Therefore, the interaction between stress, glucocorticoids, and neurite growth inhibition may be a candidate pathophysiology underlying major depressive disorder (MDD), and the identification of Capn2, Vamp7 and Cop might provide insight into treatment of MDD.
KeywordCalpain 2 (Capn2) Vesicle-associated membrane protein 7 (Vamp7) C-type natriuretic peptide (Cnp) PC12 cells Animal model of depression
DOI10.1016/j.psychres.2019.04.017
Indexed BySCI ; SCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Beijing Administration of Traditional Chinese Medicine ; Beijing Natural Science Foundation ; Beijing Health System Training Program for High Level Technique Talents
Funding ProjectNational Natural Science Foundation of China[91132728] ; National Natural Science Foundation of China[31741062] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Beijing Administration of Traditional Chinese Medicine[QN2018-33] ; Beijing Natural Science Foundation[7172063] ; Beijing Health System Training Program for High Level Technique Talents[2014-3-001]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000471358800012
PublisherELSEVIER IRELAND LTD
WOS KeywordNATRIURETIC-PEPTIDE ; PREFRONTAL CORTEX ; PC12 CELLS ; STRESS ; EXPRESSION ; DIFFERENTIATION ; LOCALIZATION ; OUTGROWTH ; PROTEIN ; TOPHAT
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/29143
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhou, JianJun; Zhao, Mei
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Shenzhen Ruipuxun Acad Stem Cell & Regenerat Med, Shenzhen 518035, Peoples R China
3.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
4.Tongji Univ, Canc Stem Cell Inst, East Hosp, Res Ctr Translat Med,Sch Med, Shanghai 200120, Peoples R China
5.Univ Chinese Acad Sci, Beijing 101408, Peoples R China
6.Capital Med Univ, Beijing Friendship Hosp, Beijing 100050, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Mingzhen,Teng, Huajing,Sun, Guangqiang,et al. Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression[J]. PSYCHIATRY RESEARCH,2019,276:79-86.
APA Li, Mingzhen.,Teng, Huajing.,Sun, Guangqiang.,Zhao, Jingjie.,Fan, Min.,...&Zhao, Mei.(2019).Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression.PSYCHIATRY RESEARCH,276,79-86.
MLA Li, Mingzhen,et al."Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression".PSYCHIATRY RESEARCH 276(2019):79-86.
Files in This Item:
File Name/Size DocType Version Access License
Transcriptome Profil(803KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Mingzhen]'s Articles
[Teng, Huajing]'s Articles
[Sun, Guangqiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Mingzhen]'s Articles
[Teng, Huajing]'s Articles
[Sun, Guangqiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Mingzhen]'s Articles
[Teng, Huajing]'s Articles
[Sun, Guangqiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Transcriptome Profiles of Corticosterone-induced Cytotoxicity Reveals the Involvement of Neurite Growth-related Genes in Depression.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.