Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression

doi:10.1016/j.psychres.2019.04.017

	Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression
	Li, Mingzhen 1,2; Teng, Huajing 3; Sun, Guangqiang 1; Zhao, Jingjie 1,6; Fan, Min 2; Zhao, Zhenlin 2; Zhou, JianJun 4; Zhao, Mei1,5
通讯作者	Zhou, JianJun(zhoujj_2000@aliyun.com) ; Zhao, Mei(zhaomei@psych.ac.cn)
摘要	Corticosterone (CORT), the main HPA-axis glucocorticoid hormone in rodents, is involved in the regulation of animal stress responses. However, the neural mechanisms underlying the effects of corticosteroids on depression are yet to be elucidated. We found that fluoxetine reversed neurite growth inhibition induced by COAT in PC12 cells, a widely used model system for neurobiological and neurotoxicological studies. Transcriptome profiling showed that 1,609 genes were up-regulated, whereas 1,764 genes were down-regulated significantly in the CORT group in comparison with the Control group. Of them, the expression of 589 DEGs was reversed after fluoxetine treatment, and genes related to cell morphogenesis, neurite growth, and immune function were involved in the neuroprotective effect of fluoxetine against CORT. Furthermore, expression of neurite growth-related genes, such as such as Calpain 2 (Capn2), vesicle-associated membrane protein 7 (Vamp7) and C-type natriuretic peptide (Cnp), altered in a brain region- or treatment-specific manner in the animal models of depression. Therefore, the interaction between stress, glucocorticoids, and neurite growth inhibition may be a candidate pathophysiology underlying major depressive disorder (MDD), and the identification of Capn2, Vamp7 and Cop might provide insight into treatment of MDD.
关键词	Calpain 2 (Capn2) Vesicle-associated membrane protein 7 (Vamp7) C-type natriuretic peptide (Cnp) PC12 cells Animal model of depression
	2019-06-01
语种	英语
DOI	10.1016/j.psychres.2019.04.017
发表期刊	PSYCHIATRY RESEARCH
ISSN	0165-1781
卷号	276 页码:79-86
收录类别	SCI ; SCI
资助项目	National Natural Science Foundation of China[91132728] ; National Natural Science Foundation of China[31741062] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Beijing Administration of Traditional Chinese Medicine[QN2018-33] ; Beijing Natural Science Foundation[7172063] ; Beijing Health System Training Program for High Level Technique Talents[2014-3-001]
出版者	ELSEVIER IRELAND LTD
WOS关键词	NATRIURETIC-PEPTIDE ; PREFRONTAL CORTEX ; PC12 CELLS ; STRESS ; EXPRESSION ; DIFFERENTIATION ; LOCALIZATION ; OUTGROWTH ; PROTEIN ; TOPHAT
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000471358800012
资助机构	National Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Beijing Administration of Traditional Chinese Medicine ; Beijing Natural Science Foundation ; Beijing Health System Training Program for High Level Technique Talents
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/29143
专题	中国科学院心理健康重点实验室
通讯作者	Zhou, JianJun; Zhao, Mei
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Shenzhen Ruipuxun Acad Stem Cell & Regenerat Med, Shenzhen 518035, Peoples R China 3.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China 4.Tongji Univ, Canc Stem Cell Inst, East Hosp, Res Ctr Translat Med,Sch Med, Shanghai 200120, Peoples R China 5.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 6.Capital Med Univ, Beijing Friendship Hosp, Beijing 100050, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li, Mingzhen,Teng, Huajing,Sun, Guangqiang,et al. Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression[J]. PSYCHIATRY RESEARCH,2019,276:79-86.
APA	Li, Mingzhen.,Teng, Huajing.,Sun, Guangqiang.,Zhao, Jingjie.,Fan, Min.,...&Zhao, Mei.(2019).Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression.PSYCHIATRY RESEARCH,276,79-86.
MLA	Li, Mingzhen,et al."Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression".PSYCHIATRY RESEARCH 276(2019):79-86.

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